help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CRATER, S. E.
Right arrow Articles by PLATTS-MILLS, T. A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CRATER, S. E.
Right arrow Articles by PLATTS-MILLS, T. A. E.

Am. J. Respir. Crit. Care Med., Volume 159, Number 3, March 1999, 806-811

Expired Nitric Oxide and Airway Obstruction in Asthma Patients with an Acute Exacerbation

SCOTT E. CRATER, EDWARD J. PETERS, MARCUS L. MARTIN, ANDREW W. MURPHY, and THOMAS A. E. PLATTS-MILLS

Asthma and Allergic Diseases Center, University of Virginia; and Department of Emergency Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia

Expired nitric oxide (eNO) is a marker of airway inflammation that is increased in asthma. The present study was undertaken to examine the clinical utility of eNO as an aid in the assessment of asthma in the emergency department (ED). Fifty-two adult patients with acute asthma, 53 age- and sex-matched controls, and eight patients with stable asthma were enrolled. Subjects performed spirometry, their eosinophil counts and serum total IgE were measured, and a sample of mixed VC expirate was collected for measurement of NO. Mixed expired NO was 8.2 ± 0.5 ppb in controls, 8.8 ± 1.5 ppb in patients with stable asthma, and 15.0 ± 1.0 ppb in patients with acute asthma. A significant difference in eNO was observed in patients with acute asthma and controls (p < 0.001). Twenty-three of the 52 patients with acute asthma versus two of 53 controls had an eNO >=  15 ppb (p < 0.001). Expired NO concentration correlated with FEV1% (r = -0.42, p < 0.001) and with the peripheral blood eosinophil count (r = 0.34, p < 0.001) in the group of 60 patients with acute and stable asthma. The sensitivity of eNO > 10 ppb and eosinophilia (> 200 cells/µl) was 90% in predicting airway obstruction (FEV1/FVC < 0.8). No relationship of eNO was found to serum IgE, self- reported smoking, or glucocorticoid use. Measurement of eNO is a promising clinical tool for assessing acute asthma.




This article has been cited by other articles:


Home page
 Eur Respir JHome page
M. B. Lund, J. Kongerud, W. Nystad, J. Boe, and J. R. Harris
Genetic and environmental effects on exhaled nitric oxide and airway responsiveness in a population-based sample of twins
Eur. Respir. J., February 1, 2007; 29(2): 292 - 298.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Prieto, L. Bruno, V. Gutierrez, S. Uixera, C. Perez-Frances, A. Lanuza, and A. Ferrer
Airway Responsiveness to Adenosine 5'-Monophosphate and Exhaled Nitric Oxide Measurements: Predictive Value as Markers for Reducing the Dose of Inhaled Corticosteroids in Asthmatic Subjects
Chest, October 1, 2003; 124(4): 1325 - 1333.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. B. Khatri, J. Hammel, M. S. Kavuru, S. C. Erzurum, and R. A. Dweik
Temporal association of nitric oxide levels and airflow in asthma after whole lung allergen challenge
J Appl Physiol, July 1, 2003; 95(1): 436 - 440.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S.L. Jones, P. Herbison, J.O. Cowan, E.M. Flannery, R.J. Hancox, C.R. McLachlan, and D.R. Taylor
Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationship
Eur. Respir. J., September 1, 2002; 20(3): 601 - 608.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Deykin, A. F. Massaro, J. M. Drazen, and E. Israel
Exhaled Nitric Oxide as a Diagnostic Test for Asthma: Online versus Offline Techniques and Effect of Flow Rate
Am. J. Respir. Crit. Care Med., June 15, 2002; 165(12): 1597 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. T. Hopfenspirger and D. K. Agrawal
Airway Hyperresponsiveness, Late Allergic Response, and Eosinophilia Are Reversed with Mycobacterial Antigens in Ovalbumin-Presensitized Mice
J. Immunol., March 1, 2002; 168(5): 2516 - 2522.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. L. JONES, J. KITTELSON, J. O. COWAN, E. M. FLANNERY, R. J. HANCOX, C. R. MCLACHLAN, and D. R. TAYLOR
The Predictive Value of Exhaled Nitric Oxide Measurements in Assessing Changes in Asthma Control
Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 738 - 743.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. ADRIE, M. MONCHI, A. TUAN DINH-XUAN, J. DALL'AVA-SANTUCCI, J.-F. DHAINAUT, and M. R. PINSKY
Exhaled and Nasal Nitric Oxide as a Marker of Pneumonia in Ventilated Patients
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1143 - 1149.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
H.-W. Shin and S. C. George
Microscopic modeling of NO and S-nitrosoglutathione kinetics and transport in human airways
J Appl Physiol, March 1, 2001; 90(3): 777 - 788.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. DEYKIN, O. BELOSTOTSKY, C. HONG, A. F. MASSARO, C. M. LILLY, and E. ISRAEL
Exhaled Nitric Oxide following Leukotriene E4 and Methacholine Inhalation in Patients with Asthma
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1685 - 1689.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. ICHINOSE, H. SUGIURA, S. YAMAGATA, A. KOARAI, and K. SHIRATO
Increase in Reactive Nitrogen Species Production in Chronic Obstructive Pulmonary Disease Airways
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 701 - 706.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. C. de JONGSTE and K. ALVING
Gas Analysis
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): S23 - 27.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society