Am. J. Respir. Crit. Care Med., Volume 159, Number 3, March 1999, 791-795

Forced Expiratory Maneuvers in Very Young Children
Assessment of Flow Limitation

MARCUS H. JONES, STEPHANIE D. DAVIS, DEBORAH GRANT, KATHY CHRISTOPH, JEFFREY KISLING, and ROBERT S. TEPPER

Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana

The application of negative expiratory pressure (NEP) to the airway opening during forced expiratory maneuvers has recently been described as a noninvasive method to assess whether flow limitation is achieved in adults. This methodology has great potential for extending the measurement of forced expiratory maneuvers to young children who may not produce maximal efforts as reproducibly as adults. We used NEP to assess flow limitation in 10 children between 3 and 5 yr of age. NEP was well tolerated by all subjects. With the application of NEP, there was not a step increase in flow, a finding consistent with flow limitation for the subjects. In addition to visual inspection, we proposed a method to quantify the change in flow during a short NEP. The flow-volume curves obtained with and without NEP were visually the same, other than the flow transients produced by NEP. The calculated values of FVC and FEF_25-75 were not significantly different when measured from flow- volume curves with and without NEP. There was a statistically significant increase in FEV₁ with NEP; however, the group mean increase in FEV₁ was less than 2%. We conclude that NEP may be a useful technique to determine whether flow limitation has been achieved in young children performing forced expiratory maneuvers.

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