help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KESSLER, R.
Right arrow Articles by WEITZENBLUM, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KESSLER, R.
Right arrow Articles by WEITZENBLUM, E.

Am. J. Respir. Crit. Care Med., Volume 159, Number 1, January 1999, 158-164

Predictive Factors of Hospitalization for Acute Exacerbation in a Series of 64 Patients with Chronic Obstructive Pulmonary Disease

ROMAIN KESSLER, MICHÈLE FALLER, GILLES FOURGAUT, BERTRAND MENNECIER, and EMMANUEL WEITZENBLUM

Service de Pneumologie, Hôpitaux Universitaires, Strasbourg, France

Hospitalizations for acute exacerbation in patients with chronic obstructive pulmonary disease (COPD) have a great impact on health care expenditure. The aim of this study was to look at predictive factors of hospitalization for acute exacerbation in a group of patients with moderate to severe COPD. During the year 1994, we included 64 patients with COPD in this study. At inclusion, the patients being in a stable state, we performed a complete evaluation of their clinical, spirometric, gasometric, and pulmonary hemodynamic characteristics. All patients were followed during a period of at least 2.5 yr. We recorded the intervals free of hospitalization for exacerbation and realized an analysis of the proportional hazards not to be hospitalized using the Kaplan-Meier method. Univariate analysis using the log-rank test showed that the risk of being hospitalized was significantly increased in patients with COPD with a low body mass index (BMI =< 20 kg/m2, p = 0.015) and in patients with a limited 6-min walk distance (=< 367 m, p = 0.045). But above all, the risk of hospitalization for acute exacerbation was significantly increased by gas exchange impairment and pulmonary hemodynamic worsening: PaO2 =< 65 mm Hg versus PaO2 > 65 mm Hg, p = 0.005; PaCO2 > 44 mm Hg versus PaCO2 =< 44 mm Hg, p = 0.005; and mean pulmonary artery pressure ( Ppa) at rest > 18 mm Hg versus Ppa =< 18 mm Hg, p = 0.0008. Neither age, nor the association of one or more comorbidities with COPD, nor the smoking habits had a significant impact on the risk of hospitalization in our study. Multivariate analysis showed that only PaCO2 and Ppa were independently related to the risk of hospitalization for acute exacerbation of COPD. We conclude that chronic hypercapnic respiratory insufficiency and pulmonary hypertension are predictive factors of hospitalization for acute exacerbation in COPD patients.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Kovacs, R. Maier, E. Aberer, M. Brodmann, S. Scheidl, N. Troster, C. Hesse, W. Salmhofer, W. Graninger, E. Gruenig, et al.
Borderline Pulmonary Arterial Pressure Is Associated with Decreased Exercise Capacity in Scleroderma
Am. J. Respir. Crit. Care Med., November 1, 2009; 180(9): 881 - 886.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, N. Galie, M. M. Hoeper, M. Humbert, A. Torbicki, J.-L. Vachiery, J. A. Barbera, M. Beghetti, P. Corris, S. Gaine, et al.
Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
Eur. Heart J., October 2, 2009; 30(20): 2493 - 2537.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
G. Kovacs, A. Berghold, S. Scheidl, and H. Olschewski
Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review
Eur. Respir. J., October 1, 2009; 34(4): 888 - 894.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Chaouat, L. Savale, C. Chouaid, L. Tu, B. Sztrymf, M. Canuet, B. Maitre, B. Housset, C. Brandt, P. Le Corvoisier, et al.
Role for Interleukin-6 in COPD-Related Pulmonary Hypertension
Chest, September 1, 2009; 136(3): 678 - 687.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. W. Sims, D. J. Margolis, A. R. Localio, R. A. Panettieri, S. M. Kawut, and J. D. Christie
Impact of Pulmonary Artery Pressure on Exercise Function in Severe COPD
Chest, August 1, 2009; 136(2): 412 - 419.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Chaouat, R. Naeije, and E. Weitzenblum
Pulmonary hypertension in COPD
Eur. Respir. J., November 1, 2008; 32(5): 1371 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N. S. Godtfredsen, T. H. Lam, T. T. Hansel, M. E. Leon, N. Gray, C. Dresler, D. M. Burns, E. Prescott, and J. Vestbo
COPD-related morbidity and mortality after smoking cessation: status of the evidence
Eur. Respir. J., October 1, 2008; 32(4): 844 - 853.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. Stolz, H. Rasch, A. Linka, M. Di Valentino, A. Meyer, M. Brutsche, and M. Tamm
A randomised, controlled trial of bosentan in severe COPD
Eur. Respir. J., September 1, 2008; 32(3): 619 - 628.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Stolz, M. Christ-Crain, N. G. Morgenthaler, D. Miedinger, J. Leuppi, C. Muller, R. Bingisser, J. Struck, B. Muller, and M. Tamm
Plasma Pro-Adrenomedullin But Not Plasma Pro-Endothelin Predicts Survival in Exacerbations of COPD
Chest, August 1, 2008; 134(2): 263 - 272.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A E Lammers, A A Hislop, Y Flynn, and S G Haworth
The 6-minute walk test: normal values for children of 4-11 years of age
Arch. Dis. Child., June 1, 2008; 93(6): 464 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
V. Kim, J. O. Benditt, R. A. Wise, and A. Sharafkhaneh
Oxygen Therapy in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, May 1, 2008; 5(4): 513 - 518.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Gonzalez, E. Servera, and J. Marin
Importance of Noninvasively Measured Respiratory Muscle Overload Among the Causes of Hospital Readmission of COPD Patients
Chest, April 1, 2008; 133(4): 941 - 947.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. H. Groenewegen, D. S. Postma, W. C. J. Hop, P. L. M. L. Wielders, N. J. J. Schlosser, E. F. M. Wouters, and for the COSMIC Study Group
Increased Systemic Inflammation Is a Risk Factor for COPD Exacerbations*
Chest, February 1, 2008; 133(2): 350 - 357.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. K. Han, V. V. McLaughlin, G. J. Criner, and F. J. Martinez
Pulmonary Diseases and the Heart
Circulation, December 18, 2007; 116(25): 2992 - 3005.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. G. Foreman, D. L. DeMeo, C. P. Hersh, J. J. Reilly, and E. K. Silverman
Clinical determinants of exacerbations in severe, early-onset COPD
Eur. Respir. J., December 1, 2007; 30(6): 1124 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. McGhan, T. Radcliff, R. Fish, E. R. Sutherland, C. Welsh, and B. Make
Predictors of Rehospitalization and Death After a Severe Exacerbation of COPD
Chest, December 1, 2007; 132(6): 1748 - 1755.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. R. Fisher, G. J. Criner, A. P. Fishman, P. M. Hassoun, O. A. Minai, S. M. Scharf, a. H. E. Fessler, and for the National Emphysema Treatment Trial (NETT)
Estimating pulmonary artery pressures by echocardiography in patients with emphysema
Eur. Respir. J., November 1, 2007; 30(5): 914 - 921.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Respir DisHome page
M. Miravitlles
Review: Do we need new antibiotics for treating exacerbations of COPD?
Therapeutic Advances in Respiratory Disease, October 1, 2007; 1(1): 61 - 76.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. F. Rabe, S. Hurd, A. Anzueto, P. J. Barnes, S. A. Buist, P. Calverley, Y. Fukuchi, C. Jenkins, R. Rodriguez-Roisin, C. van Weel, et al.
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: GOLD Executive Summary
Am. J. Respir. Crit. Care Med., September 15, 2007; 176(6): 532 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Polverino, F. P. Gomez, H. Manrique, N. Soler, J. Roca, J. A. Barbera, and R. Rodriguez-Roisin
Gas Exchange Response to Short-Acting beta2-Agonists in Chronic Obstructive Pulmonary Disease Severe Exacerbations
Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 350 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. J. Criner, S. M. Scharf, J. A. Falk, J. P. Gaughan, A. L. Sternberg, N. B. Patel, H. E. Fessler, O. A. Minai, A. P. Fishman, and for the National Emphysema Treatment Trial Researc
Effect of Lung Volume Reduction Surgery on Resting Pulmonary Hemodynamics in Severe Emphysema
Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 253 - 260.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. J. Carr, R. S. Goldstein, and D. Brooks
Acute Exacerbations of COPD in Subjects Completing Pulmonary Rehabilitation
Chest, July 1, 2007; 132(1): 127 - 134.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
British Thoracic Society Guideline Development Gro
Intermediate care--Hospital-at-Home in chronic obstructive pulmonary disease: British Thoracic Society guideline
Thorax, March 1, 2007; 62(3): 200 - 210.
[Full Text] [PDF]

Home page
 ChestHome page
D. E. Niewoehner, Y. Lokhnygina, K. Rice, W. G. Kuschner, A. Sharafkhaneh, G. A. Sarosi, P. Krumpe, K. Pieper, and S. Kesten
Risk Indexes for Exacerbations and Hospitalizations Due to COPD
Chest, January 1, 2007; 131(1): 20 - 28.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J Garcia-Aymerich, P Lange, M Benet, P Schnohr, and J M Anto
Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort study
Thorax, September 1, 2006; 61(9): 772 - 778.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Rodriguez-Roisin
COPD exacerbations {middle dot} 5: Management.
Thorax, June 1, 2006; 61(6): 535 - 544.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. Vestbo
Clinical Assessment, Staging, and Epidemiology of Chronic Obstructive Pulmonary Disease Exacerbations
Proceedings of the ATS, May 1, 2006; 3(3): 252 - 256.
[Abstract] [Full Text] [PDF]

Home page
 West J Nurs ResHome page
Y.-J. Chen and G. L. Narsavage
Factors Related to Chronic Obstructive Pulmonary Disease Readmission in Taiwan
West J Nurs Res, February 1, 2006; 28(1): 105 - 124.
[Abstract] [PDF]

Home page
 ChestHome page
K.-C. Ong, A. Earnest, and S.-J. Lu
A Multidimensional Grading System (BODE Index) as Predictor of Hospitalization for COPD
Chest, December 1, 2005; 128(6): 3810 - 3816.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Rodriguez-Roisin
Is this the beginning of unravelling the puzzle of COPD exacerbations?
Eur. Respir. J., September 1, 2005; 26(3): 376 - 378.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
G. Gudmundsson, T. Gislason, C. Janson, E. Lindberg, R. Hallin, C. S. Ulrik, E. Brondum, M. M. Nieminen, T. Aine, and P. Bakke
Risk factors for rehospitalisation in COPD: role of health status, anxiety and depression
Eur. Respir. J., September 1, 2005; 26(3): 414 - 419.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Cuvelier, C. Viacroze, J. Benichou, L. C. Molano, M-F. Hellot, D. Benhamou, and J-F. Muir
Dependency on mask ventilation after acute respiratory failure in the intermediate care unit
Eur. Respir. J., August 1, 2005; 26(2): 289 - 297.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Casas, J. Vilaro, R. Rabinovich, A. Mayer, J. A. Barbera, R. Rodriguez-Roisin, and J. Roca
Encouraged 6-min Walking Test Indicates Maximum Sustainable Exercise in COPD Patients
Chest, July 1, 2005; 128(1): 55 - 61.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. Thabut, G. Dauriat, J. B. Stern, D. Logeart, A. Levy, R. Marrash-Chahla, and H. Mal
Pulmonary Hemodynamics in Advanced COPD Candidates for Lung Volume Reduction Surgery or Lung Transplantation
Chest, May 1, 2005; 127(5): 1531 - 1536.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Strassburg, D. Droemann, G. van Zandbergen, H. Kothe, and K. Dalhoff
Enhanced PMN response in chronic bronchitis and community-acquired pneumonia
Eur. Respir. J., November 1, 2004; 24(5): 772 - 778.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Dupont, A. Gacouin, H. Lena, S. Lavoue, G. Brinchault, P. Delaval, and R. Thomas
Survival of Patients With Bronchiectasis After the First ICU Stay for Respiratory Failure
Chest, May 1, 2004; 125(5): 1815 - 1820.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S.T. Weiss, D.L. DeMeo, and D.S. Postma
COPD: problems in diagnosis and measurement
Eur. Respir. J., June 1, 2003; 21(41_suppl): 4S - 12s.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.A. Barbera, V.I. Peinado, and S. Santos
Pulmonary hypertension in chronic obstructive pulmonary disease
Eur. Respir. J., May 1, 2003; 21(5): 892 - 905.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J Pepke-Zaba and N W Morrell
Pulmonary hypertension in patients with COPD: NO treatment?
Thorax, April 1, 2003; 58(4): 283 - 284.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Inoue, H. Nakamura, K. Otake, H. Saito, K. Terashita, J. Sato, H. Takeda, and H. Tomoike
Impaired Pulmonary Inflammatory Responses Are a Prominent Feature of Streptococcal Pneumonia in Mice with Experimental Emphysema
Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 764 - 770.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J Garcia-Aymerich, E Farrero, M A Felez, J Izquierdo, R M Marrades, and J M Anto
Risk factors of readmission to hospital for a COPD exacerbation: a prospective study
Thorax, February 1, 2003; 58(2): 100 - 105.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. Chemla, V. Castelain, P. Herve, Y. Lecarpentier, and S. Brimioulle
Haemodynamic evaluation of pulmonary hypertension
Eur. Respir. J., November 1, 2002; 20(5): 1314 - 1331.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Troosters, J. Vilaro, R. Rabinovich, A. Casas, J.A. Barbera, R. Rodriguez-Roisin, and J. Roca
Physiological responses to the 6-min walk test in patients with chronic obstructive pulmonary disease
Eur. Respir. J., September 1, 2002; 20(3): 564 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
ATS Statement: Guidelines for the Six-Minute Walk Test
Am. J. Respir. Crit. Care Med., July 1, 2002; 166(1): 111 - 117.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Sohy, C. Pilette, M.S. Niederman, and Y. Sibille
Acute exacerbation of chronic obstructive pulmonary disease and antibiotics: what studies are still needed?
Eur. Respir. J., May 1, 2002; 19(5): 966 - 975.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. GARCIA-AYMERICH, E. MONSO, R. M. MARRADES, J. ESCARRABILL, M. A. FELEZ, J. SUNYER, J. M. ANTO, and the EFRAM Investigators
Risk Factors for Hospitalization for a Chronic Obstructive Pulmonary Disease Exacerbation . EFRAM STUDY
Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 1002 - 1007.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
B Schonhofer, T Barchfeld, M Wenzel, and D Kohler
Long term effects of non-invasive mechanical ventilation on pulmonary haemodynamics in patients with chronic respiratory failure
Thorax, July 1, 2001; 56(7): 524 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. SAETTA, G. TURATO, P. MAESTRELLI, C. E. MAPP, and L. M. FABBRI
Cellular and Structural Bases of Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1304 - 1309.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. A. PAUWELS, A. S. BUIST, P. M. A. CALVERLEY, C. R. JENKINS, and S. S. HURD
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease . NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1256 - 1276.
[Full Text]

Home page
 Eur Respir JHome page
M.A. Higham, D. Dawson, J. Joshi, P. Nihoyannopoulos, and N.W. Morrell
Utility of echocardiography in assessment of pulmonary hypertension secondary to COPD
Eur. Respir. J., March 1, 2001; 17(3): 350 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. C. CREUTZBERG, E. F. M. WOUTERS, I. M. L. VANDERHOVEN-AUGUSTIN, M. A. DENTENER, and A. M. W. J. SCHOLS
Disturbances in Leptin Metabolism Are Related to Energy Imbalance during Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1239 - 1245.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. GARROD, C. MIKELSONS, E. A. PAUL, and J. A. WEDZICHA
Randomized Controlled Trial of Domiciliary Noninvasive Positive Pressure Ventilation and Physical Training in Severe Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1335 - 1341.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. B. GREENBERG, M. ALLEN, J. WILSON, and R. L. ATMAR
Respiratory Viral Infections in Adults With and Without Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 167 - 173.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society 		  New Orleans Int'l Conf