help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SEOW, C. Y.
Right arrow Articles by PARÉ, P. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SEOW, C. Y.
Right arrow Articles by PARÉ, P. D.

Am. J. Respir. Crit. Care Med., Volume 158, Number 5, November 1998, S179-S186

Structural and Functional Changes in the Airway Smooth Muscle of Asthmatic Subjects

CHUN Y. SEOW, R. ROBERT SCHELLENBERG, and PETER D. PARÉ

Departments of Anatomy, Pharmacology, and Medicine, and St. Paul's Hospital Pulmonary Research Laboratory, University of British Columbia, Vancouver, British Columbia, Canada

It has been recognized since the early 1920s that the amount of smooth muscle in asthmatic subjects' airways is markedly increased. More recent studies have confirmed that in fatal asthma there is a significant increase in the thickness of airway smooth muscle. For subjects who have had asthma and who died for other reasons or had a lobectomy, the increase in muscle layer thickness is less striking. An increase in smooth muscle mass could have a dual effect on airway narrowing: one due to the thickening of airway wall, the other due to a concomitant increase in force generation. However, it is not known whether the increased muscle mass, due either to hypertrophy or hyperplasia, is accompanied by an increase in force. Proliferation of smooth muscle cells often produces noncontractile cells in vitro. Comparison of force generation by muscle preparations from asthmatic and control airways shows conflicting results, with some studies demonstrating an increase in force in asthmatic muscle preparations and others showing no increase. The discrepancy could be due to a failure to take into account the length-tension relationship of the muscle preparations in some studies. No force velocity data are available for human airway smooth muscle. However, there is some evidence for an increased amount of shortening in airway smooth muscle preparations from patients with asthma. This could be due to an increase in force generation and/or a decrease in tissue elastance in asthmatic airways. Muscle contractility and tissue elastance are in turn influenced by cytokines, matrix-degrading enzymes, and other inflammatory mediators present in the airways of asthmatic subjects. Data from in vitro studies of a canine "asthma model" indicate an increase in both shortening velocity and amount of shortening compared with littermate control animals. An increase in the compliance of the parallel elastic element of the sensitized airway preparation could account for the mechanical alterations. Seow CY, Schellenberg RR, Paré PD. Structural and functional changes in the airway smooth muscle of asthmatic subjects.




This article has been cited by other articles:


Home page
Am. J. Respir. Cell Mol. Bio.Home page
Y. Chiba, M. Todoroki, Y. Nishida, M. Tanabe, and M. Misawa
A Novel STAT6 Inhibitor AS1517499 Ameliorates Antigen-Induced Bronchial Hypercontractility in Mice
Am. J. Respir. Cell Mol. Biol., November 1, 2009; 41(5): 516 - 524.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. Chiba, S. Sato, M. Hanazaki, H. Sakai, and M. Misawa
Inhibition of geranylgeranyltransferase inhibits bronchial smooth muscle hyperresponsiveness in mice
Am J Physiol Lung Cell Mol Physiol, November 1, 2009; 297(5): L984 - L991.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
Y. Chiba, M. Tanabe, K. Goto, H. Sakai, and M. Misawa
Down-Regulation of miR-133a Contributes to Up-Regulation of RhoA in Bronchial Smooth Muscle Cells
Am. J. Respir. Crit. Care Med., October 15, 2009; 180(8): 713 - 719.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. Labonte, M. Hassan, P.-A. Risse, K. Tsuchiya, M. Laviolette, A.-M. Lauzon, and J. G. Martin
The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma
Am J Physiol Lung Cell Mol Physiol, October 1, 2009; 297(4): L698 - L705.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
Y. Chiba, S. Nakazawa, M. Todoroki, K. Shinozaki, H. Sakai, and M. Misawa
Interleukin-13 Augments Bronchial Smooth Muscle Contractility with an Up-Regulation of RhoA Protein
Am. J. Respir. Cell Mol. Biol., February 1, 2009; 40(2): 159 - 167.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
N. Regamey, M. Ochs, T. N. Hilliard, C. Muhlfeld, N. Cornish, L. Fleming, S. Saglani, E. W. F. W. Alton, A. Bush, P. K. Jeffery, et al.
Increased Airway Smooth Muscle Mass in Children with Asthma, Cystic Fibrosis, and Non-Cystic Fibrosis Bronchiectasis
Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 837 - 843.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
H. Syyong, C. Cheung, D. Solomon, C. Y. Seow, and K. H. Kuo
Adaptive response of pulmonary arterial smooth muscle to length change
J Appl Physiol, April 1, 2008; 104(4): 1014 - 1020.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. Chiba, J. Arima, H. Sakai, and M. Misawa
Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma
Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L705 - L713.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. A. Tomei, M. M. Choe, and M. A. Swartz
Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model
Am J Physiol Lung Cell Mol Physiol, January 1, 2008; 294(1): L79 - L86.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. Chitano, L. Wang, S. N. Mason, R. L. Auten, E. N. Potts, W. M. Foster, A. Sturrock, T. P. Kennedy, J. R. Hoidal, and T. M. Murphy
Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase
Am J Physiol Lung Cell Mol Physiol, January 1, 2008; 294(1): L139 - L148.
[Abstract] [Full Text] [PDF]


Home page
ThoraxHome page
H. Matsumoto, L. M Moir, B. G G Oliver, J. K Burgess, M. Roth, J. L Black, and B. E McParland
Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma
Thorax, October 1, 2007; 62(10): 848 - 854.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
A. L. James and S. Wenzel
Clinical relevance of airway remodelling in airway diseases
Eur. Respir. J., July 1, 2007; 30(1): 134 - 155.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
S. Hazarika, M. R. Van Scott, and R. M. Lust
Severity of myocardial injury following ischemia-reperfusion is increased in a mouse model of allergic asthma
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H572 - H579.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Zheng, D. Zhou, C. Y. Seow, and T. R Bai
Cardiotrophin-1 alters airway smooth muscle structure and mechanical properties in airway explants
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1165 - L1171.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
P. G. Woodruff, G. M. Dolganov, R. E. Ferrando, S. Donnelly, S. R. Hays, O. D. Solberg, R. Carter, H. H. Wong, P. S. Cadbury, and J. V. Fahy
Hyperplasia of Smooth Muscle in Mild to Moderate Asthma without Changes in Cell Size or Gene Expression
Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 1001 - 1006.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
D. J. Fernandes, R. W. Mitchell, O. Lakser, M. Dowell, A. G. Stewart, and J. Solway
Invited Review: Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
J Appl Physiol, August 1, 2003; 95(2): 844 - 853.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Kumar, A. J. Knox, and A. M. Boriek
CCAAT/Enhancer-binding Protein and Activator Protein-1 Transcription Factors Regulate the Expression of Interleukin-8 through the Mitogen-activated Protein Kinase Pathways in Response to Mechanical Stretch of Human Airway Smooth Muscle Cells
J. Biol. Chem., May 23, 2003; 278(21): 18868 - 18876.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
L. Benayoun, A. Druilhe, M.-C. Dombret, M. Aubier, and M. Pretolani
Airway Structural Alterations Selectively Associated with Severe Asthma
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1360 - 1368.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
A. Cogo, G. Napolitano, M. C. Michoud, D. R. Barbon, M. Ward, and J. G. Martin
Effects of hypoxia on rat airway smooth muscle cell proliferation
J Appl Physiol, April 1, 2003; 94(4): 1403 - 1409.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
A. M. Freyer, S. R. Johnson, and I. P. Hall
Effects of Growth Factors and Extracellular Matrix on Survival of Human Airway Smooth Muscle Cells
Am. J. Respir. Cell Mol. Biol., November 1, 2001; 25(5): 569 - 576.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
G. R. Strohmeier, J. H. Walsh, E. S. Klings, H. W. Farber, W. W. Cruikshank, D. M. Center, and M. J. Fenton
Lipopolysaccharide Binding Protein Potentiates Airway Reactivity in a Murine Model of Allergic Asthma
J. Immunol., February 1, 2001; 166(3): 2063 - 2070.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
H. TIDDENS, M. SILVERMAN, and A. BUSH
The Role of Inflammation in Airway Disease . Remodeling
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): S7 - 10.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
A. DUGUET, K. BIYAH, E. MINSHALL, R. GOMES, C.-G. WANG, M. TAOUDI-BENCHEKROUN, J. H. T. BATES, and D. H. EIDELMAN
Bronchial Responsiveness among Inbred Mouse Strains . Role of Airway Smooth-Muscle Shortening Velocity
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 839 - 848.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
J. SOLWAY
What Makes the Airways Contract Abnormally? Is It Inflammation?
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): S164 - 167.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
E. T. NAURECKAS, I. MAURICE NDUKWU, A. J. HALAYKO, C. MAXWELL, M. B. HERSHENSON, and J. SOLWAY
Bronchoalveolar Lavage Fluid from Asthmatic Subjects Is Mitogenic for Human Airway Smooth Muscle
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 2062 - 2066.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society
  SOTA, FL