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Am. J. Respir. Crit. Care Med., Volume 158, Number 5, November 1998, 1664-1668

Expression of Adhesion Molecules and G Proteins in Circulating Neutrophils in Chronic Obstructive Pulmonary Disease

AINA NOGUERA, XAVIER BUSQUETS, JAUME SAULEDA, JOSE  M. VILLAVERDE, WILLIAM MacNEE, and ALVAR G. N. AGUSTÍ

Servei de Pneumologia, Servei de Analisis Cliniques, and Unitat d'Investigació (REUNI), Hospital Universitari Son Dureta, Palma de Mallorca, Spain; and Respiratory Medicine Unit, Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom

We investigated the expression of adhesion molecules in circulating neutrophils (lymphocyte function-associated antigen-1 [LFA-1], Mac-1, and L-selectin) and endothelial cells (soluble intercellular adhesion molecule-1[sICAM-1]) in 23 patients with stable chronic obstructive pulmonary disease (COPD), 18 subjects with exacerbated COPD, and 23 healthy volunteers. Also, in these circulating neutrophils, we assessed the expression of two G protein subunits (Galpha s and Galpha i1/2). Compared with control subjects, patients with stable COPD showed increased expression of Mac-1 (p < 0.001) and lower levels of sICAM-1 (p = 0.002); LFA-1 and L-selectin expression was similar in patients and control subjects. During exacerbations, compared with stable patients, the expression of Mac-1 and LFA-1 was reduced (p < 0.001). Finally, the expression of Galpha s (but not Galpha i1/2) was also reduced (p < 0.001) in circulating neutrophils of patients with COPD, irrespective of the clinical condition of the patient. These results indicate that in patients with COPD: (1) the expression of some neutrophil adhesion molecules (Mac-1) is abnormal, and that this pattern changes during exacerbations; (2) there may be a form of endothelial dysfunction, as suggested by the low sICAM-1 levels; (3) the expression of G protein subunit (Galpha s) in circulating neutrophils is downregulated, irrespective of their clinical conditions. Overall, these results indicate the presence of significant systemic abnormalities in COPD.




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