help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by NEUMANN, P.
Right arrow Articles by HEDENSTIERNA, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NEUMANN, P.
Right arrow Articles by HEDENSTIERNA, G.

Am. J. Respir. Crit. Care Med., Volume 158, Number 5, November 1998, 1636-1643

Effect of Different Pressure Levels on the Dynamics of Lung Collapse and Recruitment in Oleic-Acid-induced Lung Injury

PETER NEUMANN, JAN E. BERGLUND, ENRIQUE F. MONDÉJAR, ANDERS MAGNUSSON, and GÖRAN HEDENSTIERNA

Department of Clinical Physiology, Department of Anesthesiology, and Department of Diagnostic Radiology, University of Uppsala, Uppsala, Sweden

The effects of different inspiratory and expiratory airway pressures (Paw) on the dynamics of lung collapse and recruitment were studied in 14 anesthetized, mechanically ventilated, pigs with oleic-acid-induced lung injury. Repetitive CT scans of the same slice were obtained every 0.8 s during different inspiration and expiration hold procedures. The mean lung density and amount of atelectasis were measured in each scan. Inspiration to a Paw of 15 cm H2O above PEEP resulted in recruitment of collapsed lung tissue, mainly within 1.4 s. During expiration lung density increased rapidly and at an almost even rate within the first 1.4 s, whereas a rapid increase of atelectasis occurred after an initial delay period of 0.6 s with PEEP = 10 or 15 cm H2O. PEEP of 20 or 25 cm H2O almost prevented lung collapse during expiration. Thus, in order to avoid cyclic alveolar collapse during mechanical ventilation in oleic-acid-induced lung injury, a PEEP level >=  20 cm H2O or an expiration time =< 0.6 s is required. Long inspiratory time intervals, as used in inverse ratio ventilation, seem to be of minor importance for the recruitment of collapsed lung tissue in this experimental model.




This article has been cited by other articles:


Home page
 ChestHome page
O. Moerer, S. Fischer, M. Hartelt, B. Kuvaki, M. Quintel, and P. Neumann
Influence of Two Different Interfaces for Noninvasive Ventilation Compared to Invasive Ventilation on the Mechanical Properties and Performance of a Respiratory System: A Lung Model Study
Chest, June 1, 2006; 129(6): 1424 - 1431.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
B. Pfeiffer, R. S. Syring, K. Markstaller, C. M. Otto, and J. E. Baumgardner
The implications of arterial po2 oscillations for conventional arterial blood gas analysis.
Anesth. Analg., June 1, 2006; 102(6): 1758 - 1764.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
G. Mols, H.-J. Priebe, and J. Guttmann
Alveolar recruitment in acute lung injury
Br. J. Anaesth., February 1, 2006; 96(2): 156 - 166.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. David, J. Karmrodt, C. Bletz, S. David, A. Herweling, H.-U. Kauczor, and K. Markstaller
Analysis of Atelectasis, Ventilated, and Hyperinflated Lung During Mechanical Ventilation by Dynamic CT
Chest, November 1, 2005; 128(5): 3757 - 3770.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. Zinserling, H. Wrigge, P. Neumann, T. Muders, A. Magnusson, G. Hedenstierna, and C. Putensen
Methodologic Aspects of Attenuation Distributions From Static and Dynamic Thoracic CT Techniques in Experimental Acute Lung Injury
Chest, October 1, 2005; 128(4): 2963 - 2970.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. B. Allen, L. A. Pavone, J. D. DiRocco, J. H. T. Bates, and G. F. Nieman
Pulmonary impedance and alveolar instability during injurious ventilation in rats
J Appl Physiol, August 1, 2005; 99(2): 723 - 730.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-J. Rouby
Optimizing Lung Aeration in Positive End-Expiratory Pressure
Am. J. Respir. Crit. Care Med., November 15, 2004; 170(10): 1039 - 1040.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. M. Albaiceta, F. Taboada, D. Parra, L. H. Luyando, J. Calvo, R. Menendez, and J. Otero
Tomographic Study of the Inflection Points of the Pressure-Volume Curve in Acute Lung Injury
Am. J. Respir. Crit. Care Med., November 15, 2004; 170(10): 1066 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. A. Victorino, J. B. Borges, V. N. Okamoto, G. F. J. Matos, M. R. Tucci, M. P. R. Caramez, H. Tanaka, F. S. Sipmann, D. C. B. Santos, C. S. V. Barbas, et al.
Imbalances in Regional Lung Ventilation: A Validation Study on Electrical Impedance Tomography
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 791 - 800.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
G. Perchiazzi, R. Giuliani, L. Ruggiero, T. Fiore, and G. Hedenstierna
Estimating Respiratory System Compliance During Mechanical Ventilation Using Artificial Neural Networks
Anesth. Analg., October 1, 2003; 97(4): 1143 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. Hinz, P. Neumann, T. Dudykevych, L. G. Andersson, H. Wrigge, H. Burchardi, and G. Hedenstierna
Regional Ventilation by Electrical Impedance Tomography: A Comparison With Ventilation Scintigraphy in Pigs
Chest, July 1, 2003; 124(1): 314 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. E. Baumgardner, K. Markstaller, B. Pfeiffer, M. Doebrich, and C. M. Otto
Effects of Respiratory Rate, Plateau Pressure, and Positive End-Expiratory Pressure on PaO2 Oscillations after Saline Lavage
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1556 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Allen, L. K. A. Lundblad, P. Parsons, and J. H. T. Bates
Transient mechanical benefits of a deep inflation in the injured mouse lung
J Appl Physiol, November 1, 2002; 93(5): 1709 - 1715.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
G. Tusman, S. H. Bohm, F. Melkun, D. Staltari, C. Quinzio, C. Nador, and E. Turchetto
Alveolar recruitment strategy increases arterial oxygenation during one-lung ventilation
Ann. Thorac. Surg., April 1, 2002; 73(4): 1204 - 1209.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
K. Markstaller, B. Eberle, H.-U. Kauczor, A. Scholz, A. Bink, M. Thelen, W. Heinrichs, and N. Weiler
Temporal dynamics of lung aeration determined by dynamic CT in a porcine model of ARDS
Br. J. Anaesth., September 1, 2001; 87(3): 459 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-C. RICHARD, S. M. MAGGIORE, B. JONSON, J. MANCEBO, F. LEMAIRE, and L. BROCHARD
Influence of Tidal Volume on Alveolar Recruitment . Respective Role of PEEP and a Recruitment Maneuver
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1609 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. A. Martynowicz, B. J. Walters, and R. D. Hubmayr
Mechanisms of recruitment in oleic acid-injured lungs
J Appl Physiol, May 1, 2001; 90(5): 1744 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
P. Neumann and G. Hedenstierna
Ventilatory Support by Continuous Positive Airway Pressure Breathing Improves Gas Exchange as Compared with Partial Ventilatory Support with Airway Pressure Release Ventilation
Anesth. Analg., April 1, 2001; 92(4): 950 - 958.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. G. HICKLING
Best Compliance during a Decremental, But Not Incremental, Positive End-Expiratory Pressure Trial Is Related to Open-Lung Positive End-Expiratory Pressure . A Mathematical Model of Acute Respiratory Distress Syndrome Lungs
Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 69 - 78.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. CAKAR, T. V. d. KLOOT, M. YOUNGBLOOD, A. ADAMS, and A. NAHUM
Oxygenation Response to a Recruitment Maneuver during Supine and Prone Positions in an Oleic Acid-Induced Lung Injury Model
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1949 - 1956.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. NEUMANN, J. E. BERGLUND, L. G. ANDERSSON, E. MARIPU, A. MAGNUSSON, and G. HEDENSTIERNA
Effects of Inverse Ratio Ventilation and Positive End-Expiratory Pressure in Oleic Acid-Induced Lung Injury
Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1537 - 1545.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society