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Am. J. Respir. Crit. Care Med., Volume 158, Number 5, November 1998, 1524-1527

8-Isoprostane as a Biomarker of Oxidative Stress in Interstitial Lung Diseases

PAOLO MONTUSCHI, GIOVANNI CIABAT TONI, PAOLO PAREDI, PANAGIOTIS PANTELIDIS, ROLAND M. du BOIS, SERGEI A. KHARITONOV, and PETER J. BARNES

Imperial College School of Medicine at the National Heart and Lung Institute, Department of Thoracic Medicine, Interstitial Lung Disease Unit, Royal Brompton Hospital, London, United Kingdom; and Institute of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy

Oxidative stress contributes to the pathophysiology of interstitial lung diseases, such as cryptogenic fibrosing alveolitis (CFA), fibrosing alveolitis associated with systemic sclerosis (FASSc) and sarcoidosis. F2-isoprostanes are a series of prostaglandin (PG) F2-like compounds produced in vivo independent of cyclooxygenase, as products of the radical-catalyzed lipid peroxidation. Measurement of the concentrations of F2-isoprostanes has proved to be valuable in assessing oxidative stress in vivo. The aim of this study was to measure 8-epi-PGF2alpha concentrations, one of the most abundant F2-isoprostane in humans, in bronchoalveolar lavage (BAL) in normal subjects and to compare them to those observed in patients with CFA (n = 9), FASSc (n = 8) and sarcoidosis (n = 10). 8-epi-PGF2alpha was detectable in BAL fluid in normal subjects (9.6 ± 0.8 pg/ml) and its concentrations were increased approximately 5-fold in patients with CFA (47.4 ± 7.0, p < 0.001) and FASSc (43.2 ± 3.3, p < 0.001). 8-epi-PGF2alpha was also increased in patients with sarcoidosis, although to a lesser extent (12.0 ± 0.70 pg/ml, p < 0.01). No correlation between 8-epi-PGF2alpha and either lung function tests or BAL cell types was observed in any group of patients. Our study shows that the level of oxidative stress is enhanced in patients with interstitial lung diseases as reflected by increased concentrations of 8-epi-PGF2alpha in BAL fluid.




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