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Am. J. Respir. Crit. Care Med., Volume 158, Number 3, September 1998, 995-997

Surfactant Homeostasis in Corticotropin-releasing Hormone Deficiency in Adult Mice

ALAN H. JOBE and MACHIKO IKEGAMI

Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio

Glucocorticoids are essential for lung maturation and pharmacologic doses of glucocorticoids increase surfactant in adult rats. Therefore, we asked if glucocorticoid deficiency in corticotropin-releasing hormone-deficient mice (CRH-/-) with very low plasma corticosterone levels would alter surfactant pool sizes and precursor incorporation into saturated phosphatidylcholine (Sat PC). Alveolar and lung tissue Sat PC pool sizes were not different for CRH-/- mice and wild-type mice. The incorporation of [3H]choline into Sat PC also was similar for the two strains of mice. Glucocorticoids are not a major regulator of surfactant homeostasis in the adult mouse.




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