help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BEHR, M. A.
Right arrow Articles by SMALL, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BEHR, M. A.
Right arrow Articles by SMALL, P. M.

Am. J. Respir. Crit. Care Med., Volume 158, Number 2, August 1998, 465-469

Predictive Value of Contact Investigation for Identifying Recent Transmission of Mycobacterium tuberculosis

MARCEL A. BEHR, PHILIP C. HOPEWELL, E. ANTONIO PAZ, L. MASAE KAWAMURA, GISELA F. SCHECTER, and PETER M. SMALL

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine; Division of Pulmonary and Critical Care Medicine and Division of Tuberculosis Control, San Francisco General Hospital and Department of Medicine, University of California, San Francisco, California

Contact tracing, the evaluation of persons who have been in contact with patients having tuberculosis, is an important component of tuberculosis control. We used DNA fingerprinting to test the assumption that tuberculosis in contacts to active cases represents transmission from that person. Cases of tuberculosis in San Francisco between 1991 and 1996 with positive cultures who had been previously identified as contacts ("contact cases") to active cases ("index cases") were studied. Of 11,211 contacts evaluated, there were 66 pairs of culture-positive index and contact cases. DNA fingerprints were available for both members of these pairs in 54 instances (82%). The index and contact cases were infected with the same strain of Mycobacterium tuberculosis in 38 instances (70%; 95% CI: 56 to 82%); 16 pairs (30%) were infected with unrelated strains. Unrelated infections were more common among foreign-born (risk ratio [RR] = 5.22, p < 0.001), particularly Asian (RR = 3.89, p = 0.002) contacts. Contact investigation is an imperfect method for detecting transmission of M. tuberculosis, particularly in foreign-born persons. However, because such investigations target a group with a high prevalence of tuberculosis and tuberculous infection, these efforts remain an important activity in the control of tuberculosis.




This article has been cited by other articles:


Home page
 ChestHome page
R. Diel, R. Loddenkemper, K. Meywald-Walter, R. Gottschalk, and A. Nienhaus
Comparative Performance of Tuberculin Skin Test, QuantiFERON-TB-Gold In Tube Assay, and T-Spot.TB Test in Contact Investigations for Tuberculosis
Chest, April 1, 2009; 135(4): 1010 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Diel, R. Loddenkemper, K. Meywald-Walter, S. Niemann, and A. Nienhaus
Predictive Value of a Whole Blood IFN-{gamma} Assay for the Development of Active Tuberculosis Disease after Recent Infection with Mycobacterium tuberculosis
Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1164 - 1170.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Diel
From the authors
Eur. Respir. J., December 1, 2006; 28(6): 1285 - 1286.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Diel, A. Nienhaus, C. Lange, and T. Schaberg
Cost-optimisation of screening for latent tuberculosis in close contacts
Eur. Respir. J., July 1, 2006; 28(1): 35 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Diel, A. Nienhaus, and T. Schaberg
Cost-effectiveness of isoniazid chemoprevention in close contacts
Eur. Respir. J., September 1, 2005; 26(3): 465 - 473.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. Mixides, V. Shende, L. D. Teeter, R. Awe, J. M. Musser, and E. A. Graviss
Number of Negative Acid-Fast Smears Needed To Adequately Assess Infectivity of Patients With Pulmonary Tuberculosis
Chest, July 1, 2005; 128(1): 108 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
O. K. Koksalan, A. N. Scott, L. Joseph, and M. A. Behr
Low Positive Predictive Values and Specificities of Spoligotyping and Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing Methods for Performing Population-Based Molecular Epidemiology Studies of Tuberculosis
J. Clin. Microbiol., June 1, 2005; 43(6): 3031 - 3032.
[Full Text] [PDF]

Home page
 ThoraxHome page
U R Dahle, S Nordtvedt, B A Winje, T Mannsaaker, E Heldal, P Sandven, H M S Grewal, and D A Caugant
Tuberculosis in contacts need not indicate disease transmission
Thorax, February 1, 2005; 60(2): 136 - 137.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
A. N. Scott, D. Menzies, T.-N. Tannenbaum, L. Thibert, R. Kozak, L. Joseph, K. Schwartzman, and M. A. Behr
Sensitivities and Specificities of Spoligotyping and Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing Methods for Studying Molecular Epidemiology of Tuberculosis
J. Clin. Microbiol., January 1, 2005; 43(1): 89 - 94.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
K. S. Blackwood, J. N. Wolfe, and A. M. Kabani
Application of Mycobacterial Interspersed Repetitive Unit Typing to Manitoba Tuberculosis Cases: Can Restriction Fragment Length Polymorphism Be Forgotten?
J. Clin. Microbiol., November 1, 2004; 42(11): 5001 - 5006.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
M. W Borgdorff, J. R Glynn, and E. Vynnycky
Using capture-recapture methods to study recent transmission of tuberculosis
Int. J. Epidemiol., August 1, 2004; 33(4): 905 - 906.
[Full Text] [PDF]

Home page
 Int J EpidemiolHome page
J. Inigo, A. Arce, and F. Chaves
Authors' response
Int. J. Epidemiol., August 1, 2004; 33(4): 907 - 907.
[Full Text] [PDF]

Home page
 Int J EpidemiolHome page
S. Verver, R. M Warren, Z. Munch, E. Vynnycky, P. D van Helden, M. Richardson, G. D van der Spuy, D. A Enarson, M. W Borgdorff, M. A Behr, et al.
Transmission of tuberculosis in a high incidence urban community in South Africa
Int. J. Epidemiol., April 1, 2004; 33(2): 351 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. van Deutekom, S. P. Hoijng, P. E. W. de Haas, M. W. Langendam, A. Horsman, D. van Soolingen, and R. A. Coutinho
Clustered Tuberculosis Cases: Do They Represent Recent Transmission and Can They Be Detected Earlier?
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 806 - 810.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. Behr
Tuberculosis due to Multiple Strains: A Concern for the Patient? A Concern for Tuberculosis Control?
Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 554 - 555.
[Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
A Seidler, A Nienhaus, and R Diel
The transmission of tuberculosis in the light of new molecular biological approaches
Occup. Environ. Med., February 1, 2004; 61(2): 96 - 102.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M.V. Burgos and A.S. Pym
Molecular epidemiology of tuberculosis
Eur. Respir. J., July 1, 2002; 20(36_suppl): 54S - 65s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. T. NITTA, L. S. KNOWLES, J. KIM, E. L. LEHNKERING, L. A. BORENSTEIN, P. T. DAVIDSON, S. M. HARVEY, and M. L. DE KONING
Limited Transmission of Multidrug-Resistant Tuberculosis Despite a High Proportion of Infectious Cases in Los Angeles County, California
Am. J. Respir. Crit. Care Med., March 15, 2002; 165(6): 812 - 817.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Lauzardo, E. S. Hollender, M. Narita, and D. Ashkin
Who Dunnit? : The Changing Face of Tuberculosis Control Utilizing Restriction Fragment Length Polymorphism
Chest, December 1, 2001; 120(6): 1765 - 1768.
[Full Text] [PDF]

Home page
 Arch Intern MedHome page
L. Tan, R. D. Altman, N. H. Nielsen, and for the Council on Scientific Affairs, American Me
Screening Nonimmigrant Visitors to the United States for Tuberculosis: Report of the Council on Scientific Affairs
Arch Intern Med, February 12, 2001; 161(3): 334 - 340.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. N. Lobato, J. C. Mohle-Boetani, and S. E. Royce
Missed Opportunities for Preventing Tuberculosis Among Children Younger Than Five Years of Age
Pediatrics, December 1, 2000; 106(6): 75e - 75.
[Abstract] [Full Text]

Home page
 JAMAHome page
D. P. Chin, C. M. Crane, M. Y. Diul, S. J. Sun, R. Agraz, S. Taylor, E. Desmond, and F. Wise
Spread of Mycobacterium tuberculosis in a Community Implementing Recommended Elements of Tuberculosis Control
JAMA, June 14, 2000; 283(22): 2968 - 2974.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
D. N. Rose
Benefits of Screening for Latent Mycobacterium tuberculosis Infection
Arch Intern Med, May 22, 2000; 160(10): 1513 - 1521.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
P. F. Barnes
Reducing Ongoing Transmission of Tuberculosis
JAMA, November 18, 1998; 280(19): 1702 - 1703.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society 		  ATS 2008 State of the Art Course