help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WITHERS, N. J.
Right arrow Articles by CLOUGH, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WITHERS, N. J.
Right arrow Articles by CLOUGH, J. B.

Am. J. Respir. Crit. Care Med., Volume 158, Number 2, August 1998, 352-357

The Natural History of Respiratory Symptoms in a Cohort of Adolescents

NICHOLAS J. WITHERS, LORRAINE LOW, STEPHEN T. HOLGATE, and JOANNE B. CLOUGH

University Medicine, University Child Health, and Department of Medical Statistics, Southampton General Hospital, Southampton, United Kingdom

A cohort of 2,289 children, previously studied at the age of 6-8 yr, were followed up by means of a postal questionnaire when aged 14 -16 yr to examine the association between potential risk factors and the natural history of respiratory symptoms. Children with current symptoms, persistent symptoms, and late-onset symptoms were identified and multivariate analyses were performed to determine the independent association between risk factors and these various symptom-based subgroups. Personal and family history of atopy was significantly associated with all symptom groups and with the presence of doctor-diagnosed asthma. Smoking, either active or passive, was shown to be significantly associated with current, persistent, and late-onset symptoms. Other factors shown to be significantly associated with certain symptom groups were gender (late-onset wheeze), single-parent households (current cough, persistent cough), social class (late-onset wheeze), number of children in the household (persistent wheeze, late-onset cough), number of furry pets in the household (current wheeze), birth weight (late-onset wheeze), and gas cookers (current wheeze, persistent wheeze). In a subgroup of children studied in more detail in 1987, bronchial hyperresponsiveness in 1987 was positively associated with persistent wheeze in 1995, whereas positive skin-prick testing in 1987 was not.




This article has been cited by other articles:


Home page
 Arch. Dis. Child.Home page
R van Gent, G de Meer, M M Rovers, J L L Kimpen, C K van der Ent, and L E M van Essen
Adherence to follow-up recommendations in asthma
Arch. Dis. Child., March 1, 2008; 93(3): 236 - 238.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J Mallol, J A Castro-Rodriguez, E Cortez, V Aguirre, P Aguilar, and L Barrueto
Heightened bronchial hyperresponsiveness in the absence of heightened atopy in children with current wheezing and low income status
Thorax, February 1, 2008; 63(2): 167 - 171.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. Bjerg, L. Hedman, M. S. Perzanowski, T. Platts-Mills, B. Lundback, and E. Ronmark
Family History of Asthma and Atopy: In-depth Analyses of the Impact on Asthma and Wheeze in 7- to 8-Year-Old Children
Pediatrics, October 1, 2007; 120(4): 741 - 748.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
W. Eder, M. J. Ege, and E. von Mutius
The asthma epidemic.
N. Engl. J. Med., November 23, 2006; 355(21): 2226 - 2235.
[Full Text] [PDF]

Home page
 ThoraxHome page
J Genuneit, G Weinmayr, K Radon, H Dressel, D Windstetter, P Rzehak, C Vogelberg, W Leupold, D Nowak, E von Mutius, et al.
Smoking and the incidence of asthma during adolescence: results of a large cohort study in Germany
Thorax, July 1, 2006; 61(7): 572 - 578.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
G. de Bilderling, A. J. Chauhan, J. A. R. Jeffs, N. Withers, S. L. Johnston, S. T. Holgate, and J. B. Clough
Gas Cooking and Smoking Habits and the Risk of Childhood and Adolescent Wheeze
Am. J. Epidemiol., September 15, 2005; 162(6): 513 - 522.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Guerra, A. L. Wright, W. J. Morgan, D. L. Sherrill, C. J. Holberg, and F. D. Martinez
Persistence of Asthma Symptoms during Adolescence: Role of Obesity and Age at the Onset of Puberty
Am. J. Respir. Crit. Care Med., July 1, 2004; 170(1): 78 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
D. D. Sin, S. Spier, L. W. Svenson, D. P. Schopflocher, A. Senthilselvan, R. L. Cowie, and S. F. P. Man
The Relationship Between Birth Weight and Childhood Asthma: A Population-Based Cohort Study
Arch Pediatr Adolesc Med, January 1, 2004; 158(1): 60 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Public HealthHome page
R. da Costa Lima, C. G. Victora, A. M. B. Menezes, and F. C. Barros
Do Risk Factors for Childhood Infections and Malnutrition Protect Against Asthma? A Study of Brazilian Male Adolescents
Am J Public Health, November 1, 2003; 93(11): 1858 - 1864.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
L. B. Bacharier and R. C. Strunk
Pets and Childhood Asthma--How Should the Pediatrician Respond to New Information That Pets May Prevent Asthma?
Pediatrics, October 1, 2003; 112(4): 974 - 976.
[Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
M Osman
Therapeutic implications of sex differences in asthma and atopy
Arch. Dis. Child., July 1, 2003; 88(7): 587 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
B. P. Yawn, P. Wollan, P. Scanlon, and M. Kurland
Are We Ready for Universal School-Based Asthma Screening?: An Outcomes Evaluation
Arch Pediatr Adolesc Med, December 1, 2002; 156(12): 1256 - 1262.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Ernst, H. Ghezzo, and M.R. Becklake
Risk factors for bronchial hyperresponsiveness in late childhood and early adolescence
Eur. Respir. J., September 1, 2002; 20(3): 635 - 639.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. R. Ownby, C. C. Johnson, and E. L. Peterson
Exposure to Dogs and Cats in the First Year of Life and Risk of Allergic Sensitization at 6 to 7 Years of Age
JAMA, August 28, 2002; 288(8): 963 - 972.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
W Xuan, G B Marks, B G Toelle, E Belousova, J K Peat, G Berry, and A J Woolcock
Risk factors for onset and remission of atopy, wheeze, and airway hyperresponsiveness
Thorax, February 1, 2002; 57(2): 104 - 109.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. G. GIBSON, J. L. SIMPSON, A. C. CHALMERS, R. C. TONEGUZZI, P. A. B. WARK, A. J. WILSON, and M. J. HENSLEY
Airway Eosinophilia Is Associated with Wheeze But Is Uncommon in Children with Persistent Cough and Frequent Chest Colds
Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 977 - 981.
[Abstract] [Full Text] [PDF]

Home page
 Indoor and Built EnvironmentHome page
R. J. Witorsch and P. Witorsch
Review : Environmental Tobacco Smoke and Respiratory Health in Children: A Critical Review and Analysis of the Literature from 1969 to 19981
Indoor and Built Environment, September 1, 2000; 9(5): 246 - 264.
[Abstract] [PDF]

Home page
 ChestHome page
F. Rasmussen, H. C. Siersted, J. Lambrechtsen, H. S. Hansen, and N.-C. G. Hansen
Impact of Airway Lability, Atopy, and Tobacco Smoking on the Development of Asthma-Like Symptoms in Asymptomatic Teenagers
Chest, May 1, 2000; 117(5): 1330 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. B. TAGER
Smoking and Childhood Asthma---Where Do We Stand?
Am. J. Respir. Crit. Care Med., August 1, 1998; 158(2): 349 - 351.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society 		  ATS Clinical Skills Tests