Am. J. Respir. Crit. Care Med., Volume 158, Number 1, July 1998, 289-298

Long-term Particulate and Other Air Pollutants and Lung Function in Nonsmokers

DAVID E. ABBEY, RAOUL J. BURCHETTE, SYNNØVE F. KNUTSEN, WILLIAM F. MCDONNELL, MICHAEL D. LEBOWITZ, and PAUL L. ENRIGHT

Loma Linda University, School of Public Health, Loma Linda, California; U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; and University of Arizona Prevention Center and Respiratory Sciences Center, Tucson, Arizona

The associations between lung function measures (spirometry and peak expiratory flow lability) and estimated 20-yr ambient concentrations of respirable particles, suspended sulfates, sulfur dioxide, ozone, and indoor particles were studied in a sample of 1,391 nonsmokers followed since 1977. Differences in air pollutants across the population were associated with decrements of lung function. An increase of 54 d/yr when particles < 10 µm in diameter (PM₁₀) exceeded 100 µg/m³ was associated with a 7.2% decrement in FEV₁, as percent of predicted, in males whose parents had asthma, bronchitis, emphysema, or hay fever and with increased peak expiratory flow lability of 0.8% for all females and 0.6% for all males. An increase in mean SO₄ concentration of 1.6 µg/m³ was associated with a 1.5% decrement in FEV₁, as percent of predicted, in all males. An increase of 23 ppb of ozone as an 8-h average was associated with a 6.3% decrement in FEV₁, as percent of predicted, in males whose parents had asthma, bronchitis, emphysema, or hay fever.

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