help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by AIDA, A.
Right arrow Articles by the Respiratory Failure Research Group in Japan
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by AIDA, A.
Right arrow Articles by the Respiratory Failure Research Group in Japan,

Am. J. Respir. Crit. Care Med., Volume 158, Number 1, July 1998, 188-193

Prognostic Value of Hypercapnia in Patients with Chronic Respiratory Failure during Long-term Oxygen Therapy

AKIRA AIDA, KENJI MIYAMOTO, MASAHARU NISHIMURA, MIYOJI AIBA, SHIRO KIRA, YOSHIKAZU KAWAKAMI, and the Respiratory Failure Research Group in Japan

First Department of Medicine, Hokkaido University, School of Medicine, Sapporo; and Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan

Hypercapnia observed in patients with chronic respiratory failure may not be an ominous sign for prognosis when they are receiving long-term oxygen therapy (LTOT). In this study, we selected 4,552 patients with chronic obstructive pulmonary disease (COPD) and 3,028 with sequelae of pulmonary tuberculosis (TBsq) receiving LTOT from 1985 to 1993 throughout Japan and prospectively analyzed their prognoses. The hypercapnic patients (PaCO2 >=  45 mm Hg) had a better prognosis than the normocapnic patients (35 =< PaCO2 < 45 mm Hg) for TBsq, but no difference was found between the two groups with COPD. Furthermore, Cox's proportional hazards model revealed that in TBsq hypercapnia was an independent factor for favorable prognosis, and that the relative risk for mortality was 0.76 in patients with 45 =< PaCO2 < 55 mm Hg, 0.64 for those with 55 =< PaCO2 < 65 mm Hg, and 0.49 for patients with PaCO2 >= 65 mm Hg against normocapnic patients. This favorable effect of hypercapnia in TBsq was particularly apparent in the patients without severe airway obstruction. Even a rise of 5 mm Hg or more in PaCO2 over the initial 6- to 18-mo follow-up period was not associated with poor prognosis in TBsq, although it was in COPD. From these findings, we conclude that hypercapnia should not be generally considered an ominous sign for prognosis in those patients who receive LTOT.




This article has been cited by other articles:


Home page
 ERRHome page
S. Budweiser, RudolfA. Jorres, T. Riedl, F. Heinemann, and M. Pfeifer
Base excess, a marker of chronic hypercapnic respiratory failure and predictor of survival in COPD
Eur. Respir. Rev., December 1, 2006; 15(101): 194 - 196.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
K Nishimura
Lung health in Japan
Chronic Respiratory Disease, April 1, 2006; 3(2): 104 - 105.
[Abstract] [PDF]

Home page
 ThoraxHome page
P M Turkington and M W Elliott
Rationale for the use of non-invasive ventilation in chronic ventilatory failure
Thorax, May 1, 2000; 55(5): 417 - 423.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Rossi
Noninvasive Ventilation Has Not Been Shown To Be Ineffective in Stable COPD
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 688 - 689.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society