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Am. J. Respir. Crit. Care Med., Volume 158, Number 1, July 1998, 111-114

Analysis of HLA-DPB1 Polymorphisms in African-Americans with Sarcoidosis

MARY J. MALIARIK, KANG MEI CHEN, MARCIE L. MAJOR, ROBERTA G. SHEFFER, JOHN POPOVICH Jr., BENJAMIN A. RYBICKI, and MICHAEL C. IANNUZZI

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Department of Biostatistics and Research Epidemiology, Henry Ford Health Sciences Center, Detroit, Michigan

Several studies have found weak associations between certain human leukocyte antigen (HLA) alleles and sarcoidosis, but none have been conclusive. Glutamic acid at position 69 in HLA-DPB1 has been reported to be strongly associated with chronic beryllium disease. The immunopathologic and clinical similarities between chronic beryllium disease (CBD) and sarcoidosis suggest that similar immune-response genes may be involved in susceptibility in both diseases. We analyzed the DNA sequence of HLA-DPB1 exon 2, which contains the hypervariable regions involved in binding antigens, in blood samples from African-American sarcoidosis patients and healthy controls. Results indicate that Val36 (odds ratio [OR] = 2.30) and Asp55 (OR = 2.03) are associated with increased risk for sarcoidosis, but no association with Glu69 was found. These results suggest that although HLA-DPB1 Glu69 is not associated with sarcoidosis, other alleles may make some contribution to susceptibility to sarcoidosis in African-Americans.




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