Am. J. Respir. Crit. Care Med., Volume 157, Number 6, June 1998, 1785-1790

Pulmonary Gas Exchange Improves in the Prone Position with Abdominal Distension

MARGARETA MURE, ROBB W. GLENNY, KAREN B. DOMINO, and MICHAEL P. HLASTALA

Departments of Anesthesiology, Medicine, and Physiology and Biophysics, University of Washington, School of Medicine, Seattle, Washington

Arterial blood oxygenation in patients with adult respiratory distress syndrome is often improved in the prone position. Critically ill patients often have abdominal distension and whether similar improvements in gas exchange occur with the prone position is not known. We therefore studied the effect of posture on gas exchange in eight ketamine-anesthetized pigs with abdominal distension. A rubber balloon, placed in the abdominal cavity, was filled with water to increase intra-abdominal pressure. The animals were mechanically ventilated with FI_O2 = 0.4, and Pa_CO2 was kept constant. Gas exchange was measured in the supine and prone positions, with and without abdominal distension, in random order, using the multiple inert gas elimination technique (MIGET). When the abdomen was normal, the prone position increased Pa_O2 by 16 ± 21 mm Hg (p < 0.05), accompanied by a small, but statistically insignificant, decrease in AaPO₂ (p = 0.08) and no change in ventilation/perfusion ( A/) heterogeneity measured by MIGET. In the presence of abdominal distension, the prone position increased Pa _O2 by 26 ± 18 mm Hg (p < 0.01) and decreased AaPO₂ (p < 0.05) and A/ heterogeneity as measured by the log standard deviation of the perfusion distribution (p < 0.01) and the arterial-alveolar difference area (p < 0.05). In addition, intragastric pressure was lower in the prone position (p < 0.01). We conclude that in anesthetized, mechanically ventilated pigs, the prone position improves pulmonary gas exchange to a greater degree in the presence of abdominal distension than when the abdomen is normal.

This article has been cited by other articles:

				P. Pelosi, L. Brazzi, and L. Gattinoni Prone position in acute respiratory distress syndrome Eur. Respir. J., October 1, 2002; 20(4): 1017 - 1028. [Abstract] [Full Text] [PDF]

				R. S. Harris, D.-B. Willey-Courand, C. A. Head, G. G. Galletti, D. M. Call, and J. G. Venegas Regional VA, Q, and VA/Q during PLV: effects of nitroprusside and inhaled nitric oxide J Appl Physiol, January 1, 2002; 92(1): 297 - 312. [Abstract] [Full Text] [PDF]

				G. RIALP, A. J. BETBESE, M. PEREZ-MARQUEZ, and J. MANCEBO Short-term Effects of Inhaled Nitric Oxide and Prone Position in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome Am. J. Respir. Crit. Care Med., July 15, 2001; 164(2): 243 - 249. [Abstract] [Full Text] [PDF]

				R. Hering, H. Wrigge, R. Vorwerk, K. A. Brensing, S. Schroder, J. Zinserling, A. Hoeft, T. V. Spiegel, and C. Putensen The Effects of Prone Positioning on Intraabdominal Pressure and Cardiovascular and Renal Function in Patients with Acute Lung Injury Anesth. Analg., May 1, 2001; 92(5): 1226 - 1231. [Abstract] [Full Text] [PDF]

				M. Mure, K. B. Domino, S. G. E. Lindahl, M. P. Hlastala, W. A. Altemeier, and R. W. Glenny Regional ventilation-perfusion distribution is more uniform in the prone position J Appl Physiol, March 1, 2000; 88(3): 1076 - 1083. [Abstract] [Full Text] [PDF]