Am. J. Respir. Crit. Care Med.,
Volume 157, Number 5, May 1998, 1623-1629
Fixed Maximal Stroke Index in Patients
after Pneumonectomy
OMAR M.
HIJAZI,
MURUGAPPAN
RAMANATHAN,
AARON S.
ESTRERA,
RONALD M.
PESHOCK,
and
CONNIE C. W.
HSIA
Departments of Pediatrics, Surgery, Radiology, and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
Patients who have undergone pneumonectomy (PNX) show limited exercise capacity, partly attributable to an impaired stroke index (SI). To determine whether this limitation is due to deconditioning, we assessed exercise performance and cardiopulmonary function in seven patients after PNX (age:
59 ± 2 yr, mean ± SEM) and eight normal, healthy nonsmokers (52 ± 3 yr) before and after an ergometer exercise training program for 30 min per day, 5 d per week, for 8 wk at 65% of measured maximal O2 uptake. Lung volume, diffusing capacity of carbon dioxide (DLCO) and cardiac index (CI) were determined during steady-state exercise by a rebreathing method. Exercise endurance was measured
at 80% of maximal power. As compared with normal subjects, patients who had had PNX showed diminished maximal oxygen uptake (
O2max), as well as diminished lung volumes, ventilatory capacities,
and maximal cardiac and stroke indexes. After training, O2max, endurance, and peripheral O2 extraction improved in both groups. However, maximal cardiac and stroke indexes increased only in normal subjects and not in patients. We conclude that an irreversibly fixed maximal SI is a major source
of exercise limitation after PNX, probably because of pulmonary arterial hypertension and/or mechanical distortion of the cardiac fossa. Ventilatory impairment after PNX did not prevent a training-induced increase in O2max. Exercise training confers significant functional benefit on postpneumonectomy patients by enhancing peripheral O2 extraction.
