Am. J. Respir. Crit. Care Med., Volume 157, Number 5, May 1998, 1586-1592

Abnormalities of Gastric Mucosal Oxygenation in Septic Shock
Partial Responsiveness to Dopexamine

BETTINA TEMMESFELD-WOLLBRÜCK, ANTAL SZALAY, KONSTANTIN MAYER, HORST OLSCHEWSKI, WERNER SEEGER, and FRIEDRICH GRIMMINGER

Department of Internal Medicine, Justus-Liebig-University, Giessen, Germany

Splanchnic mucosal perfusion abnormalities have been implicated in the development of sepsis and multiorgan failure. We employed reflectance spectrophotometry for direct assessment of the microvascular hemoglobin oxygen saturation (Hbi_O2) and hemoglobin concentration (rel Hb_conc) in the mucosa of the upper gastrointestinal tract. Owing to the high recording frequency together with a small catchment volume, assessment of spatial heterogeneity is enabled. Results were as follows: In healthy controls (n = 7), mean Hbi_O2 was 70.3 ± 2.1%, with narrow dispersion and near-Gaussian distribution of the histogram. In patients presenting with hyperdynamic septic shock (n = 15) mean Hbi_O2 was reduced to 51.0 ± 1.6% in spite of high normal whole-body oxygen delivery, with tailing of the histogram to severely hypoxic values (18.4 % of data < 40%). In parallel, markedly reduced rel Hb_conc values were recorded and the standardized intramucosal pH (pHi) was lowered to 7.25 ± 0.01. Short-term infusion of dopexamine (2 µg/kg/min) caused a significant rise in Hbi_O2 and rel Hb_conc , whereas whole-body oxygen uptake and standardized pHi values were not altered. In conclusion, decreased oxygenation and tissue hemoglobin concentration, with the appearance of severely hypoxic microdomains, were noted in patients with hyperdynamic sepsis, strongly suggesting pronounced microcirculatory disturbances in this compartment. The partial responsiveness of these abnormalities to dopexamine warrants further elucidation. Temmesfeld-Wollbrück B, Szalay A, Mayer K, Olschewski H, Seeger W, Grimminger F. Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine.

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