help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DUPONT, L. J.
Right arrow Articles by VERLEDEN, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DUPONT, L. J.
Right arrow Articles by VERLEDEN, G. M.

Am. J. Respir. Crit. Care Med., Volume 157, Number 3, March 1998, 894-898

Exhaled Nitric Oxide Correlates with Airway Hyperresponsiveness in Steroid-naive Patients with Mild Asthma

LIEVEN J. DUPONT, FELICIEN ROCHETTE, MAURITS G. DEMEDTS, and GEERT M. VERLEDEN

Department of Pulmonary Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium

Endogenously released nitric oxide (NO) has been detected in the exhaled air of humans. Exhaled NO (NOexh) levels have been significantly increased in patients with inflammatory airways disorders such as asthma, and NOexh has been suggested to be a usable marker of airway inflammation. In the present study, NOexh levels were measured both in steroid-treated and untreated subjects with mild asthma, and were correlated with the degree of airway hyperresponsiveness (AHR), measured as the dose of histamine that produced a 20% decrease in FEV1 (PC20histamine). NOexh levels, which were significantly increased in steroid-naive patients (Group A1: NOexh = 21 ± 11 ppb; n = 56) in comparison with levels in control subjects (Group B: NOexh = 10 ± 2 ppb; n = 20; p < 0.001), correlated significantly with the PC20histamine (r = -0.65; p < 0.0001). The NOexh level was significantly lower in patients with chronic cough of other causes than bronchial asthma (Group A2: NOexh = 11 ± 3 ppb; n = 18) when compared with the level in subjects with mild asthma (Group A1: p < 0.001). Therefore, the noninvasive measurement of NOexh allowed us to discriminate, among patients with respiratory complaints, between those with and without AHR. In asthmatic subjects treated with inhaled steroids, the NOexh levels were significantly lower (Group A3: NOexh = 13 ± 5 ppb; n = 25) than in untreated subjects (Group A1; p < 0.01), and there was no relationship with the PC20histamine (r = -0.18, p = NS). These findings confirm that NOexh reflects AHR in patients with mild asthma who have not already been treated with inhaled steroids. Patients treated with inhaled steroids had an NOexh level comparable to levels in control subjects, although AHR could still be demonstrated.




This article has been cited by other articles:


Home page
 Eur Respir JHome page
H. Maarsingh, B. E. Bossenga, I. S. T. Bos, H. H. Volders, J. Zaagsma, and H. Meurs
L-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction
Eur. Respir. J., July 1, 2009; 34(1): 191 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
G. Rodway, J Choi, L. Hoffman, and J. Sethi
Exhaled nitric oxide in the diagnosis and management of asthma: clinical implications
Chronic Respiratory Disease, February 1, 2009; 6(1): 19 - 29.
[Abstract] [PDF]

Home page
 ChestHome page
M.-J. Oh, J.-Y. Lee, B.-J. Lee, and D.-C. Choi
Exhaled Nitric Oxide Measurement Is Useful for the Exclusion of Nonasthmatic Eosinophilic Bronchitis in Patients With Chronic Cough
Chest, November 1, 2008; 134(5): 990 - 995.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Meurs, R. Gosens, and J. Zaagsma
Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models
Eur. Respir. J., August 1, 2008; 32(2): 487 - 502.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. G. Lim and C. Mottram
The Use of Fraction of Exhaled Nitric Oxide in Pulmonary Practice
Chest, May 1, 2008; 133(5): 1232 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
P. Y. Hahn, T. I. Morgenthaler, and K. G. Lim
Use of Exhaled Nitric Oxide in Predicting Response to Inhaled Corticosteroids for Chronic Cough
Mayo Clin. Proc., November 1, 2007; 82(11): 1350 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. B. Lund, J. Kongerud, W. Nystad, J. Boe, and J. R. Harris
Genetic and environmental effects on exhaled nitric oxide and airway responsiveness in a population-based sample of twins
Eur. Respir. J., February 1, 2007; 29(2): 292 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. A. Birrell, K. McCluskie, E. Hardaker, R. Knowles, and M. G. Belvisi
Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model
Eur. Respir. J., December 1, 2006; 28(6): 1236 - 1244.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E Truyen, L Coteur, E Dilissen, L Overbergh, L J Dupont, J L Ceuppens, and D M A Bullens
Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients
Thorax, March 1, 2006; 61(3): 202 - 208.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Delclaux, F. Zerah-Lancner, B. Mahut, S. Ribeil, A. Dubois, C. Larger, and A. Harf
Alveolar Nitric Oxide and Effect of Deep Inspiration During Methacholine Challenge
Chest, May 1, 2005; 127(5): 1696 - 1702.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005
Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 912 - 930.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
X. Baur and L. Barbinova
Latex allergen exposure increases exhaled nitric oxide in symptomatic healthcare workers
Eur. Respir. J., February 1, 2005; 25(2): 309 - 316.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. R. Morris, M. Poljakovic, L. Lavrisha, L. Machado, F. A. Kuypers, and S. M. Morris Jr.
Decreased Arginine Bioavailability and Increased Serum Arginase Activity in Asthma
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 148 - 153.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. L. M. Ricciardolo, P. J. Sterk, B. Gaston, and G. Folkerts
Nitric Oxide in Health and Disease of the Respiratory System
Physiol Rev, July 1, 2004; 84(3): 731 - 765.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
P. E. Silkoff, F. A. Romero, N. Gupta, R. G. Townley, and H. Milgrom
Exhaled Nitric Oxide in Children With Asthma Receiving Xolair (Omalizumab), a Monoclonal Anti-Immunoglobulin E Antibody
Pediatrics, April 1, 2004; 113(4): e308 - e312.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P J Franklin, S W Turner, P N Le Souef, and S M Stick
Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children
Thorax, December 1, 2003; 58(12): 1048 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A R A Sovijarvi, T Haahtela, H J Ekroos, A Lindqvist, A Saarinen, T Poussa, and L A Laitinen
Sustained reduction in bronchial hyperresponsiveness with inhaled fluticasone propionate within three days in mild asthma: time course after onset and cessation of treatment
Thorax, June 1, 2003; 58(6): 500 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. Moscato, J-L. Malo, and D. Bernstein
Diagnosing occupational asthma: how, how much, how far?
Eur. Respir. J., May 1, 2003; 21(5): 879 - 885.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G.M. Verleden, L.J. Dupont, M. Delcroix, D. Van Raemdonck, J. Vanhaecke, T. Lerut, and M. Demedts
Exhaled nitric oxide after lung transplantation: impact of the native lung
Eur. Respir. J., March 1, 2003; 21(3): 429 - 432.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. J. Dupont, M. G. Demedts, and G. M. Verleden
Prospective Evaluation of the Validity of Exhaled Nitric Oxide for the Diagnosis of Asthma
Chest, March 1, 2003; 123(3): 751 - 756.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
F L M Ricciardolo
Multiple roles of nitric oxide in the airways
Thorax, February 1, 2003; 58(2): 175 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
B-;M. Sundblad, B-;M. Larsson, L. Palmberg, and K. Larsson
Exhaled nitric oxide and bronchial responsiveness in healthy subjects exposed to organic dust
Eur. Respir. J., August 1, 2002; 20(2): 426 - 431.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Beck-Ripp, M. Griese, S. Arenz, C. Koring, B. Pasqualoni, and P. Bufler
Changes of exhaled nitric oxide during steroid treatment of childhood asthma
Eur. Respir. J., June 1, 2002; 19(6): 1015 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J D Leuppi, S H Downs, S R Downie, G B Marks, and C M Salome
Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptoms
Thorax, June 1, 2002; 57(6): 518 - 523.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. L. Hall, B. Reinmann, J. H. Wildhaber, and U. Frey
Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure
J Appl Physiol, January 1, 2002; 92(1): 59 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. TERADA, T. FUJISAWA, K. TOGASHI, T. MIYAZAKI, H. KATSUMATA, J. ATSUTA, K. IGUCHI, H. KAMIYA, and H. TOGARI
Exhaled Nitric Oxide Decreases during Exercise-induced Bronchoconstriction in Children with Asthma
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1879 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.D. Leuppi, C.M. Salome, C.R. Jenkins, H. Koskela, J.D. Brannan, S.D. Anderson, M. Andersson, H.K. Chan, and A.J. Woolcock
Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma
Eur. Respir. J., September 1, 2001; 18(3): 444 - 450.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
D C Chambers and J G Ayres
Effect of nebulised L- and D-arginine on exhaled nitric oxide in steroid naive asthma
Thorax, August 1, 2001; 56(8): 602 - 606.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. A. KHARITONOV and P. J. BARNES
Exhaled Markers of Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1693 - 1722.
[Full Text] [PDF]

Home page
 ChestHome page
L.-P. Ho, F. T. Wood, A. Robson, J. A. Innes, and A. P. Greening
Atopy Influences Exhaled Nitric Oxide Levels in Adult Asthmatics
Chest, November 1, 2000; 118(5): 1327 - 1331.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. Ménard and E. Y. Bissonnette
Priming of Alveolar Macrophages by Leukotriene D4 . Potentiation of Inflammation
Am. J. Respir. Cell Mol. Biol., October 1, 2000; 23(4): 572 - 577.
[Abstract] [Full Text]

Home page
 ThoraxHome page
M. Silvestri, D. Spallarossa, E. Battistini, V. Brusasco, and G. A Rossi
Dissociation between exhaled nitric oxide and hyperresponsiveness in children with mild intermittent asthma
Thorax, June 1, 2000; 55(6): 484 - 488.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. E. SILKOFF, J. T. SYLVESTER, N. ZAMEL, and S. PERMUTT
Airway Nitric Oxide Diffusion in Asthma . Role in Pulmonary Function and Bronchial Responsiveness
Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1218 - 1228.
[Abstract] [Full Text]

Home page
 ChestHome page
F. M. Delen, J. M. Sippel, M. L. Osborne, S. Law, N. Thukkani, and W. E. Holden
Increased Exhaled Nitric Oxide in Chronic Bronchitis: Comparison With Asthma and COPD
Chest, March 1, 2000; 117(3): 695 - 701.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. SCOLLO, S. ZANCONATO, R. ONGARO, C. ZARAMELLA, F. ZACCHELLO, and E. BARALDI
Exhaled Nitric Oxide and Exercise-Induced Bronchoconstriction in Asthmatic Children
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 1047 - 1050.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S. Lim, A. Jatakanon, S. Meah, T. Oates, K. F. Chung, and P. J Barnes
Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma
Thorax, March 1, 2000; 55(3): 184 - 188.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Silkoff
Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children---1999 . THIS OFFICIAL STATEMENT OF THE AMERICAN THORACIC SOCIETY WAS ADOPTED BY THE ATS BOARD OF DIRECTORS, JULY 1999
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 2104 - 2117.
[Full Text]

Home page
 ChestHome page
B. D. Johnson, K. C. Beck, R. J. Zeballos, and I. M. Weisman
Advances in Pulmonary Laboratory Testing
Chest, November 1, 1999; 116(5): 1377 - 1387.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. M. Verleden, L. J. Dupont, A. C. Verpeut, and M. G. Demedts
The Effect of Cigarette Smoking on Exhaled Nitric Oxide in Mild Steroid-Naive Asthmatics
Chest, July 1, 1999; 116(1): 59 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. M. CHATKIN, K. ANSARIN, P. E. SILKOFF, P. MCCLEAN, C. GUTIERREZ, N. ZAMEL, and K. R. CHAPMAN
Exhaled Nitric Oxide as a Noninvasive Assessment of Chronic Cough
Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1810 - 1813.
[Abstract] [Full Text]

Home page
 ChestHome page
C. M. Hart
Nitric Oxide in Adult Lung Disease
Chest, May 1, 1999; 115(5): 1407 - 1417.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. CHAN-YEUNG, H. OBATA, M. DITTRICK, H. CHAN, and R. ABBOUD
Airway Inflammation, Exhaled Nitric Oxide, and Severity of Asthma in Patients with Western Red Cedar Asthma
Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1434 - 1438.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. E. CRATER, E. J. PETERS, M. L. MARTIN, A. W. MURPHY, and T. A. E. PLATTS-MILLS
Expired Nitric Oxide and Airway Obstruction in Asthma Patients with an Acute Exacerbation
Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 806 - 811.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society 		  ATS Quiz on Sleep Study Tracings