help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by REDLINE, S.
Right arrow Articles by ROSENBERG, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by REDLINE, S.
Right arrow Articles by ROSENBERG, C.

Am. J. Respir. Crit. Care Med., Volume 157, Number 3, March 1998, 858-865

Improvement of Mild Sleep-disordered Breathing with CPAP Compared with Conservative Therapy

SUSAN REDLINE, NANCY ADAMS, MILTON E. STRAUSS, THERESA ROEBUCK, MARY WINTERS, and CARL ROSENBERG

Departments of Medicine, Psychology, and Neurology, Case Western Reserve University; and Cleveland Veterans Affairs Medical Center, Cleveland, Ohio

The aim of this randomized controlled trial was to assess the effects of treatment with continuous positive airway pressure versus conservative therapy (CT) on well-being, mood, and functional status in subjects with mild sleep-disordered breathing (SDB). One hundred and eleven subjects, aged 25 to 65 yr, with a respiratory disturbance index (RDI) of 5 to 30 and without subjective pathologic sleepiness, were randomized to nasal CPAP or to CT. Ninety-seven subjects were followed-up after 8 wk. Treatment response was assessed from changes between baseline and follow-up measures of mood, energy/fatigue, and functional status/general health. Of the 51 subjects randomized to CPAP, 25 (49%) experienced an improved outcome, as compared with 12 of 46 of subjects (26%) randomized to CT (p < 0.05). The odds of experiencing a treatment response in the CPAP as compared with the CT group were 2.72 (OR: 1.18 to 6.58, 95% CI). A beneficial effect of CPAP over CT was most evident among individuals without sinus problems and among subjects with hypertension or diabetes. Differential treatment responses were not related to degree of baseline sleepiness or SDB. This suggests that middle-aged snorers with relatively low levels of SDB (RDI < 30) may benefit more from nasal CPAP than from less specific therapy directed at improving breathing during sleep. CPAP therapy may be beneficial to a broader group of subjects than previously appreciated.




This article has been cited by other articles:


Home page
 ChestHome page
R. K. Kakkar and R. B. Berry
Positive Airway Pressure Treatment for Obstructive Sleep Apnea
Chest, September 1, 2007; 132(3): 1057 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
B. Lam, K. Sam, W. Y. Mok, M. T. Cheung, D. Y. Fong, J. C. Lam, D. C. Lam, L. Y. Yam, and M. S. lp
Randomised study of three non-surgical treatments in mild to moderate obstructive sleep apnoea
Thorax, April 1, 2007; 62(4): 354 - 359.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
N S Marshall, M Barnes, N Travier, A J Campbell, R J Pierce, R D McEvoy, A M Neill, and P H Gander
Continuous positive airway pressure reduces daytime sleepiness in mild to moderate obstructive sleep apnoea: a meta-analysis
Thorax, May 1, 2006; 61(5): 430 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. I. Pack
Advances in Sleep-disordered Breathing
Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 7 - 15.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
E. N. Simantirakis, S. E. Schiza, S. I. Chrysostomakis, G. I. Chlouverakis, N. C. Klapsinos, N. M. Siafakas, and P. E. Vardas
Atrial Overdrive Pacing for the Obstructive Sleep Apnea-Hypopnea Syndrome
N. Engl. J. Med., December 15, 2005; 353(24): 2568 - 2577.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
N S Marshall, A M Neill, A J Campbell, and D S Sheppard
Randomised controlled crossover trial of humidified continuous positive airway pressure in mild obstructive sleep apnoea
Thorax, May 1, 2005; 60(5): 427 - 432.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. Lloberes, S. Marti, G. Sampol, A. Roca, T. Sagales, X. Munoz, and M. Ferrer
Predictive Factors of Quality-of-Life Improvement and Continuous Positive Airway Pressure Use in Patients With Sleep Apnea-Hypopnea Syndrome: Study at 1 Year
Chest, October 1, 2004; 126(4): 1241 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Barnes, R. D. McEvoy, S. Banks, N. Tarquinio, C. G. Murray, N. Vowles, and R. J. Pierce
Efficacy of Positive Airway Pressure and Oral Appliance in Mild to Moderate Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., September 15, 2004; 170(6): 656 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Gurubhagavatula, G. Maislin, J. E. Nkwuo, and A. I. Pack
Occupational Screening for Obstructive Sleep Apnea in Commercial Drivers
Am. J. Respir. Crit. Care Med., August 15, 2004; 170(4): 371 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Gagnadoux, X.L. Nguyen, D. Rakotonanahary, S. Vidal, and B. Fleury
Wrist-actigraphic estimation of sleep time under nCPAP treatment in sleep apnoea patients
Eur. Respir. J., June 1, 2004; 23(6): 891 - 895.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
S. Redline, H. L. Kirchner, S. F. Quan, D. J. Gottlieb, V. Kapur, and A. Newman
The Effects of Age, Sex, Ethnicity, and Sleep-Disordered Breathing on Sleep Architecture
Arch Intern Med, February 23, 2004; 164(4): 406 - 418.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N. Pelletier-Fleury, N. Meslier, F. Gagnadoux, C. Person, D. Rakotonanahary, H. Ouksel, B. Fleury, and J-L. Racineux
Economic arguments for the immediate management of moderate-to-severe obstructive sleep apnoea syndrome
Eur. Respir. J., January 1, 2004; 23(1): 53 - 60.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
U. J. Magalang, J. Dmochowski, S. Veeramachaneni, A. Draw, M. J. Mador, A. El-Solh, and B. J. B. Grant
Prediction of the Apnea-Hypopnea Index From Overnight Pulse Oximetry
Chest, November 1, 2003; 124(5): 1694 - 1701.
[Abstract] [Full Text] [PDF]

Home page
 Biol Res NursHome page
E. R. Chasens, T. E. Weaver, and M. G. Umlauf
Insulin Resistance and Obstructive Sleep Apnea: Is Increased Sympathetic Stimulation the Link?
Biol Res Nurs, October 1, 2003; 5(2): 87 - 96.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
S. R. Patel, D. P. White, A. Malhotra, M. L. Stanchina, and N. T. Ayas
Continuous Positive Airway Pressure Therapy for Treating gess in a Diverse Population With Obstructive Sleep Apnea: Results of a Meta-analysis
Arch Intern Med, March 10, 2003; 163(5): 565 - 571.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. F. Fitzpatrick, C. E. D. Alloway, T. M. Wakeford, A. W. MacLean, P. W. Munt, and A. G. Day
Can Patients with Obstructive Sleep Apnea Titrate Their Own Continuous Positive Airway Pressure?
Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 716 - 722.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
S. T. Kuna
A 54-Year-Old Man With Obstructive Sleep Apnea
JAMA, October 23, 2002; 288(16): 2032 - 2039.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
B.M. Sanner, M. Heise, B. Knoben, M. Machnick, U. Laufer, R. Kikuth, W. Zidek, and B. Hellmich
MRI of the pharynx and treatment efficacy of a mandibular advancement device in obstructive sleep apnoea syndrome
Eur. Respir. J., July 1, 2002; 20(1): 143 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. M. Engleman
When Does `Mild' Obstructive Sleep Apnea/Hypopnea Syndrome Merit Continuous Positive Airway Pressure Treatment?
Am. J. Respir. Crit. Care Med., March 15, 2002; 165(6): 743 - 745.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. BARNES, D. HOUSTON, C. J. WORSNOP, A. M. NEILL, I. J. MYKYTYN, A. KAY, J. TRINDER, N. A. SAUNDERS, R. D. MCEVOY, and R. J. PIERCE
A Randomized Controlled Trial of Continuous Positive Airway Pressure in Mild Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., March 15, 2002; 165(6): 773 - 780.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. J. Douglas, H. M. Engleman, J. F. Faccenda, and N. McArdle
THE SCIENCE OF DESIGNING ETHICAL CPAP TRIALS
Am. J. Respir. Crit. Care Med., January 1, 2002; 165(1): 132a - 134.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
T.A. McFadyen, C.A. Espie, N. McArdle, N.J. Douglas, and H.M. Engleman
Controlled, prospective trial of psychosocial function before and after continuous positive airway pressure therapy
Eur. Respir. J., December 1, 2001; 18(6): 996 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. I. PACK, J. E. BLACK, J. R. L. SCHWARTZ, and J. K. MATHESON
Modafinil as Adjunct Therapy for Daytime Sleepiness in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1675 - 1681.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. MONASTERIO, S. VIDAL, J. DURAN, M. FERRER, C. CARMONA, F. BARBE, M. MAYOS, N. GONZALEZ-MANGADO, M. JUNCADELLA, A. NAVARRO, et al.
Effectiveness of Continuous Positive Airway Pressure in Mild Sleep Apnea-Hypopnea Syndrome
Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 939 - 943.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
F. Barbe, L. R. Mayoralas, J. Duran, J. F. Masa, A. Maimo, J. M. Montserrat, C. Monasterio, M. Bosch, A. Ladaria, M. Rubio, et al.
Treatment with Continuous Positive Airway Pressure Is Not Effective in Patients with Sleep Apnea but No Daytime Sleepiness: A Randomized, Controlled Trial
Ann Intern Med, June 5, 2001; 134(11): 1015 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. G. HENKE, J. J. GRADY, and S. T. KUNA
Effect of Nasal Continuous Positive Airway Pressure on Neuropsychological Function in Sleep Apnea-Hypopnea Syndrome . A Randomized, Placebo-controlled Trial
Am. J. Respir. Crit. Care Med., March 15, 2001; 163(4): 911 - 917.
[Abstract] [Full Text]

Home page
 ChestHome page
M. D. Epstein, S. A. Chicoine, and R. C. Hanumara
Detection of Upper Airway Resistance Syndrome Using a Nasal Cannula/Pressure Transducer
Chest, April 1, 2000; 117(4): 1073 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. N. KINGSHOTT, M. VENNELLE, C. J. HOY, H. M. ENGLEMAN, I. J. DEARY, and N. J. DOUGLAS
Predictors of Improvements in Daytime Function Outcomes with CPAP Therapy
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 866 - 871.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Narkiewicz, M. Kato, B. G. Phillips, C. A. Pesek, D. E. Davison, and V. K. Somers
Nocturnal Continuous Positive Airway Pressure Decreases Daytime Sympathetic Traffic in Obstructive Sleep Apnea
Circulation, December 7, 1999; 100(23): 2332 - 2335.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. I. Loube
Technologic Advances in the Treatment of Obstructive Sleep Apnea Syndrome
Chest, November 1, 1999; 116(5): 1426 - 1433.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. A. Massie, R. W. Hart, K. Peralez, and G. N. Richards
Effects of Humidification on Nasal Symptoms and Compliance in Sleep Apnea Patients Using Continuous Positive Airway Pressure
Chest, August 1, 1999; 116(2): 403 - 408.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. I. Loube, P. C. Gay, K. P. Strohl, A. I. Pack, D. P. White, and N. A. Collop
Indications for Positive Airway Pressure Treatment of Adult Obstructive Sleep Apnea Patients: A Consensus Statement
Chest, March 1, 1999; 115(3): 863 - 866.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. BALLESTER, J. R. BADIA, L. HERNÁNDEZ, E. CARRASCO, J. de PABLO, C. FORNAS, R. RODRIGUEZ-ROISIN, and J. M. MONTSERRAT
Evidence of the Effectiveness of Continuous Positive Airway Pressure in the Treatment of Sleep Apnea/Hypopnea Syndrome
Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 495 - 501.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society 		  ATS Par News