help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by IKEGAMI, M.
Right arrow Articles by JOBE, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by IKEGAMI, M.
Right arrow Articles by JOBE, A. H.

Am. J. Respir. Crit. Care Med., Volume 157, Number 2, February 1998, 638-644

Effects of Ventilation Style on Surfactant Metabolism and Treatment Response in Preterm Lambs

MACHIKO IKEGAMI, KAZUKO WADA, GEORGE A. EMERSON, CELSO M. REBELLO, RAFAEL E. HERNANDEZ, and ALAN H. JOBE

Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California

We investigated whether the style of ventilation would influence respiratory physiology or surfactant metabolism in surfactant-treated preterm lambs. Preterm lambs were delivered at 131 ± 1 d gestation and treated with an organic solvent extract of sheep surfactant (100 mg/kg). The lambs were randomized to ventilation peiods of 2 h, 5 h, 10 h, or 24 h, and to ventilation with a low rate (15 breaths/min) and high VT (15 ml/kg), with a high rate (50 breaths/min) and low VT (8 ml/kg), or with high-frequency oscillatory ventilation (HFOV). Gas exchange and lung volumes were similar across time and for the different ventilation styles. Saturated phosphatidylcholine (SatPC) in alveolar lavage was lower for the HFOV group than for the other ventilation groups at 10 h and 24 h. The rate of loss of surfactant protein B (SP-B) from these preterm animals' lungs was slow and not influenced by ventilation style. The percentages of surfactants in large-aggregate forms were not changed by style of ventilation, and the large-aggregate surfactants had excellent function when tested in surfactant- deficient preterm rabbits. Alveolar lavage protein was low (30 ml/kg), and tissue hyaluronan did not change with time or ventilation style. In preterm lambs ventilated without causing injury, the extreme styles of ventilation examined in the study had minimal effects on lung function, surfactant function, or surfactant metabolism.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
B. A. YODER, T. SILER-KHODR, V. T. WINTER, and J. J. COALSON
High-frequency Oscillatory Ventilation . Effects on Lung Function, Mechanics, and Airway Cytokines in the Immature Baboon Model for Neonatal Chronic Lung Disease
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1867 - 1876.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. MICHNA, A. H. JOBE, and M. IKEGAMI
Positive End-expiratory Pressure Preserves Surfactant Function in Preterm Lambs
Am. J. Respir. Crit. Care Med., August 1, 1999; 160(2): 634 - 639.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. R. SEIDNER, A. H. JOBE, J. J. COALSON, and M. IKEGAMI
Abnormal Surfactant Metabolism and Function in Preterm Ventilated Baboons
Am. J. Respir. Crit. Care Med., December 1, 1998; 158(6): 1982 - 1989.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Wada, M. G. Ervin, and M. Ikegami
Effect of ventilation style on cardiovascular and renal adaptation in preterm newborn lambs
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1998; 275(3): R836 - R843.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society