Am. J. Respir. Crit. Care Med., Volume 157, Number 2, February 1998, 580-585

Respective and Combined Effects of Prone Position and Inhaled Nitric Oxide in Patients with Acute Respiratory Distress Syndrome

LAURENT PAPAZIAN, FABIENNE BREGEON, FRANÇOISE GAILLAT, XAVIER THIRION, MARC GAINNIER, RÉGINE GREGOIRE, PIERRE SAUX, FRANÇOIS GOUIN, YVES JAMMES, and JEAN-PIERRE AUFFRAY

Service de Réanimation, and Service d'Information Médicale, Hôpital Sainte-Marguerite, Marseille, France; and Laboratoire de Physiopathologie, Faculté de Médecine de Marseille-Nord, France

Inhaled nitric oxide (NO) and prone position (PP) are two of the new therapeutics proposed in the setting of acute respiratory distress syndrome (ARDS). The aim of this study was to evaluate the hemodynamic and respiratory effects of NO and prone position in patients with ARDS. Fourteen patients, sedated, paralyzed, and ventilated using volume-control mode, were prospectively investigated. All patients had a radial artery catheter, a pulmonary artery catheter, and a 3-F fiberoptic thermistor catheter advanced via the femoral artery into the descending aorta. The protocol consisted of seven phases: baseline measurements in supine position, SP (T0); SP + NO (T1); baseline 2 in SP (T2); PP without NO (T3); NO + PP (T4); SP + NO (T5); and PP + NO (T6). Inhaled NO (T1) induced an increase in PO₂/FI_O2 (from 128 ± 44 to 180 ± 75 mm Hg, p < 0.004). Prone position (T3) resulted in an increase in PO₂/FI_O2 (193 ± 83 mm Hg, p < 0.003 versus T0). The association of NO with PP (T4) resulted in a significant improvement in PO₂/FI_O2 (261 ± 98 mm Hg) when compared with T0, T1, and T3. Analysis of variance showed a significant and additive effect of NO and PP on both PO₂/ FI_O2 (p < 0.000) and shunt fraction ( S/ T) (p < 0.01). Since the association of NO with PP presents additive effects on oxygenation, this association can be proposed for the treatment of ARDS.

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