help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LAMBLIN, C.
Right arrow Articles by TONNEL, A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LAMBLIN, C.
Right arrow Articles by TONNEL, A. B.

Am. J. Respir. Crit. Care Med., Volume 157, Number 2, February 1998, 394-402

Bronchial Neutrophilia in Patients with Noninfectious Status Asthmaticus

CATHERINE LAMBLIN, PHILIPPE GOSSET, ISABELLE TILLIE-LEBLOND, FABIENNE SAULNIER, CHARLES-HUGO MARQUETTE, B. WALLAERT, and A. B. TONNEL

Clinique des Maladies Respiratoires, Hôpital A. Calmette, CHRU, 59037 Lille; INSERM U416, Institut Pasteur, BP 245, 59019 Lille Cedex; and Service d'Urgences Respiratoires et de Réanimation Médicale, Hôpital A. Calmette, CHRU, 59037 Lille, France

Cellular events that occur in status asthmaticus (SA) remain poorly investigated. Autopsy studies frequently emphasized about the presence of eosinophils in bronchial airway wall, whereas recent studies reported increased number of neutrophils in patients dying of sudden-onset fatal asthma. Mucus plugs occluding the bronchial lumen are almost constant features during SA. Bronchial lavage (BL) may be useful to remove mucus plugs in cases of atelectasis and/or refractory SA. We investigated the contribution of different cell types and cellular mediators (neutrophil elastase, eosinophil cationic protein [ECP], histamine, interleukin-8 [IL-8]) to the pathogenesis of SA. We studied 16 BL from eight patients undergoing mechanical ventilation (MV) for SA (time interval from onset of MV = Day 0 to Day 11), four BL from patients undergoing MV without preexisting respiratory disease (V), 11 BL from patients with stable asthma (A) and eight BL from healthy controls (C). SA exhibited higher number and percentage of neutrophils (81.5 ± 4.5%) than V (44.3 ± 12.2) (p < 0.05), A (6.9 ± 2.7) and C (9.5 ± 3.8) (p < 0.0001), and higher number of eosinophils than V, A, and C (p < 0.01). Neutrophil elastase, ECP, and IL-8 levels were dramatically increased in SA. Histamine was higher in SA than in C and V (p < 0.05). Bronchial neutrophilia was not related to concomitant bacterial infection as bacteriological cultures were positive in only three BL. Eosinophils, mast cells and histamine were higher in BL performed within the first 48 h of MV (p < 0.05) than in BL performed later on. Our results indicate that bronchial inflammation in SA differs from bronchial inflammation in mild asthma. Persistent bronchial neutrophilia is associated with increased eosinophils and mast cells in the early phase of SA. Neutrophils may result in tissue damage and participate to the shedding of the epithelium in SA.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Ley
Weird and weirder: how circulating chemokines coax neutrophils to the lung
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L463 - L464.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. M. Fabbri, M. Romagnoli, L. Corbetta, G. Casoni, K. Busljetic, G. Turato, G. Ligabue, A. Ciaccia, M. Saetta, and A. Papi
Differences in Airway Inflammation in Patients with Fixed Airflow Obstruction Due to Asthma or Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 418 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P. W. Hellings, A. Kasran, Z. Liu, P. Vandekerckhove, A. Wuyts, L. Overbergh, C. Mathieu, and J. L. Ceuppens
Interleukin-17 Orchestrates the Granulocyte Influx into Airways after Allergen Inhalation in a Mouse Model of Allergic Asthma
Am. J. Respir. Cell Mol. Biol., January 1, 2003; 28(1): 42 - 50.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Le Bourgeois, M. Goncalves, L. Le Clainche, M.-R. Benoist, J.-C. Fournet, P. Scheinmann, and J. de Blic
Bronchoalveolar Cells in Children < 3 Years Old With Severe Recurrent Wheezing*
Chest, September 1, 2002; 122(3): 791 - 797.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Oudin and J. Pugin
Role of MAP Kinase Activation in Interleukin-8 Production by Human BEAS-2B Bronchial Epithelial Cells Submitted to Cyclic Stretch
Am. J. Respir. Cell Mol. Biol., July 1, 2002; 27(1): 107 - 114.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. M. Schuh, K. Blease, and C. M. Hogaboam
CXCR2 Is Necessary for the Development and Persistence of Chronic Fungal Asthma in Mice
J. Immunol., February 1, 2002; 168(3): 1447 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Aggarwal and A. L. Gurney
IL-17: prototype member of an emerging cytokine family
J. Leukoc. Biol., January 1, 2002; 71(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-P. LAVOIE, K. MAGHNI, M. DESNOYERS, R. TAHA, J. G. MARTIN, and Q. A. HAMID
Neutrophilic Airway Inflammation in Horses with Heaves Is Characterized by a Th2-type Cytokine Profile
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1410 - 1413.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Wenzel
Proceedings of the ATS Workshop on Refractory Asthma . Current Understanding, Recommendations, and Unanswered Questions
Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2341 - 2351.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. A. BECKY KELLY, W. W. BUSSE, and N. N. JARJOUR
Increased Matrix Metalloproteinase-9 in the Airway after Allergen Challenge
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 1157 - 1161.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. TILLIE-LEBLOND, H. HAMMAD, S. DESURMONT, J. PUGIN, B. WALLAERT, A.-B. TONNEL, and P. GOSSET
CC Chemokines and Interleukin-5 in Bronchial Lavage Fluid from Patients with Status Asthmaticus . Potential Implication in Eosinophil Recruitment
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 586 - 592.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Zaitsu, Y. Hamasaki, M. Matsuo, A. Kukita, K. Tsuji, M. Miyazaki, R. Hayasaki, E. Muro, S. Yamamoto, I. Kobayashi, et al.
New induction of leukotriene A4 hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes
Blood, July 15, 2000; 96(2): 601 - 609.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M. J Leckie, S. A Bryan, J. Khan, A. Dewar, S. L Aikman, J. McGrath, D. A Okrongly, J. F Burman, P. J Barnes, and T. T Hansel
Automated quantitation of circulating neutrophil and eosinophil activation in asthmatic patients
Thorax, June 1, 2000; 55(6): 471 - 477.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. L. ORDOÑEZ, T. E. SHAUGHNESSY, M. A. MATTHAY, and J. V. FAHY
Increased Neutrophil Numbers and IL-8 Levels in Airway Secretions in Acute Severe Asthma . Clinical and Biologic Significance
Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1185 - 1190.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. M. Dwyer and J. M. Farley
Human neutrophil elastase releases two pools of mucinlike glycoconjugate from tracheal submucosal gland cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L675 - L682.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. JATAKANON, C. UASUF, W. MAZIAK, S. LIM, K. F. CHUNG, and P. J. BARNES
Neutrophilic Inflammation in Severe Persistent Asthma
Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1532 - 1539.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. E. WENZEL, L. B. SCHWARTZ, E. L. LANGMACK, J. L. HALLIDAY, J. B. TRUDEAU, R. L. GIBBS, and H. W. CHU
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Am. J. Respir. Crit. Care Med., September 1, 1999; 160(3): 1001 - 1008.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. M. Page, G. J. Gleich, K. A. Roebuck, and L. L. Thomas
Stimulation of Neutrophil Interleukin-8 Production by Eosinophil Granule Major Basic Protein
Am. J. Respir. Cell Mol. Biol., August 1, 1999; 21(2): 230 - 237.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. HOSHINO, J. LOTVALL, B.-E. SKOOGH, and A. LINDEN
Neutrophil Recruitment by Interleukin-17 into Rat Airways In Vivo . Role of Tachykinins
Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1423 - 1428.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. LEMJABBAR, P. GOSSET, C. LAMBLIN, I. TILLIE, D. HARTMANN, B. WALLAERT, A. B. TONNEL, and C. LAFUMA
Contribution of 92 kDa Gelatinase/Type IV Collagenase in Bronchial Inflammation during Status Asthmaticus
Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): 1298 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. TILLIE-LEBLOND, J. PUGIN, C.-H. MARQUETTE, C. LAMBLIN, F. SAULNIER, A. BRICHET, B. WALLAERT, A.-B. TONNEL, and P. GOSSET
Balance between Proinflammatory Cytokines and Their Inhibitors in Bronchial Lavage from Patients with Status Asthmaticus
Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 487 - 494.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1998 American Thoracic Society 		  New Orleans Int'l Conf