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Am. J. Respir. Crit. Care Med., Volume 156, Number 5, November 1997, 1483-1486

Effect of tPA on Regional Lung Perfusion in Unilobar Canine Pulmonary Thromboembolism

TAKESHI IKEDA, SEIKI NAKATANI, HIDENAO TAKATA, MIZUHO NOSAKA, AKITERU YOSHIKAWA, HIROTOMI TANAKA, and SUSUMU YUKAWA

The Third Department of Internal Medicine and the Department of Medical Engineering, Wakayama Medical College, Wakayama City, Japan

We investigated effects of tissue-type plasminogen activator (tPA) on regional pulmonary arterial hemodynamics in pulmonary thromboembolism (PTE) in a canine model of unilobar PTE. Ten beagle dogs were divided into two groups---tPA (n = 5) and control group (n = 5). In each dog an artificial blood circuit (ABC) consisting of a silicone tube and a cannulation-type electromagnetic blood flowmeter probe was placed at the left lower pulmonary artery. A unilobar PTE was induced by placing autologous clots into a metallic coil inside the ABC. The CO2 sampling tubes were positioned at the orifice of the left lower bronchus and the trachea, and the end-expiratory CO2 partial pressure (PETCO2) was measured. In the tPA group, blood flow at the left lower pulmonary artery (LL-flow) was improved to near baseline within approximately 30 min of receiving tPA, and PETCO2 at the left lower bronchus (LL-PETCO2) increased in direct correlation with LL-flow. The hemodynamic improvement after tPA therapy correlated with the partial pressure of the regional pulmonary expiratory CO2. Moreover, it was suggested that changes in physiologic conditions in PTE were not determined by clot quantity alone.






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Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1997 American Thoracic Society 		  Tobacco