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Am. J. Respir. Crit. Care Med., Volume 156, Number 4, October 1997, 1263-1264

Ribavirin Therapy for Adenovirus Pneumonia in an AIDS Patient

CAROLINE MASLO, PIERRE-MARIE GIRARD, THIERRY URBAN, SABINE GUESSANT, and WILLY ROZENBAUM

Service des Maladies Infectieuses et Tropicales, Hôpital Rothschild, Paris; Service de Pneumologie, Hôpital Saint-Antoine, Paris; and Pharmacie, Hôpital Rothschild, Paris, France

We report the effectiveness of ribavirin in an AIDS patient with multinodular pneumonia due to adenovirus. A 38-year-old AIDS patient who experienced multiple opportunistic infections and whose CD4 lymphocyte count was 5/mm3 developed bilateral nodular lung opacities. Lung surgical biopsy yielded necrotizing pneumonitis with characteristic nuclear inclusions and positive immunocytology with adenovirus antibodies. Marked clinical and radiological improvement was obtained after intravenous then oral ribavirin. Ribavirin was discontinued after 40 d because of anemia. Relapse of pneumonia with respiratory distress led to death 8 mo later. This observation illustrates a rarely reported pulmonary opportunistic infection in AIDS and the potential value of ribavirin therapy for adenovirus pneumonia.




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Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1997 American Thoracic Society 		  CCM abstracts