help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DOYLE, I. R.
Right arrow Articles by NICHOLAS, T. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DOYLE, I. R.
Right arrow Articles by NICHOLAS, T. E.

Am. J. Respir. Crit. Care Med., Volume 156, Number 4, October 1997, 1217-1229

Surfactant Proteins-A and -B Are Elevated in Plasma of Patients with Acute Respiratory Failure

IAN R. DOYLE, ANDREW D. BERSTEN, and TERENCE E. NICHOLAS

Departments of Human Physiology and Critical Care Medicine, School of Medicine, Flinders Medical Centre, Adelaide, Australia

Surfactant protein-A (SP-A) leaks into the circulation of patients with acute respiratory distress syndrome (ARDS) or acute cardiogenic pulmonary edema (APE) in a manner inversely related to lung function. Since surfactant protein-B (SP-B) is synthesized as a precursor considerably smaller than alveolar SP-A, we investigated whether it enters the circulation more readily. Reactivities consistent with SP-B proprotein (~ 42 to ~ 45 kD) and the ~ 25 kD processing intermediate were detected in plasma. Plasma immunoreactive SP-B levels were significantly higher in ARDS (8,007 ± 1,654 ng/ml [mean ± SEM], n = 22) and APE (3,646 ± 635 ng/ml, n = 10) patients compared with normal subjects (1,685 ± 58 ng/ml, n = 33) and ventilated patients with no cardiorespiratory disease (1,829 ± 184 ng/ml, n = 7). All groups had plasma SP-B/SP-A ratios ~ 6- to ~ 8-fold higher than in normal lavage or ARDS tracheal aspirate fluid, consistent with protein sieving. During admission, both plasma SP-B and the SP-B/SP-A ratio were inversely related to blood oxygenation (PaO2/FIO2) (p < 0.0001 and p < 0.025, n = 260 from 39 patients; Spearman) and static respiratory system compliance (Delta V/Delta P) (p < 0.0001 and p < 0.01, n = 168 from 25 patients). We describe in detail three patients and conclude that immunoreactive SP-B enters more readily than SP-A, is cleared acutely, and provides a better indicator of lung trauma.




This article has been cited by other articles:


Home page
 DMMHome page
J. A. Bastarache and T. S. Blackwell
Development of animal models for the acute respiratory distress syndrome
Dis. Model. Mech., May 1, 2009; 2(5-6): 218 - 223.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. X. L. Zhang, J. J. Miller, D. B. Stolz, L. D. Serpero, W. Zhao, D. Gozal, and Y. Wang
Type I Epithelial Cells Are the Main Target of Whole-Body Hypoxic Preconditioning in the Lung
Am. J. Respir. Cell Mol. Biol., March 1, 2009; 40(3): 332 - 339.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
B. Samten, J. C. Townsend, Z. Sever-Chroneos, V. Pasquinelli, P. F. Barnes, and Z. C. Chroneos
An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosis
J. Leukoc. Biol., July 1, 2008; 84(1): 115 - 123.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Woischnik, A. Bauer, R. Aboutaam, A. Pamir, F. Stanzel, J. de Blic, and M. Griese
Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis
Eur. Respir. J., June 1, 2008; 31(6): 1197 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
N. J. Meyer and J. G. N. Garcia
Wading into the Genomic Pool to Unravel Acute Lung Injury Genetics
Proceedings of the ATS, January 1, 2007; 4(1): 69 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
O C Ioachimescu and M S Kavuru
Pulmonary alveolar proteinosis
Chronic Respiratory Disease, July 1, 2006; 3(3): 149 - 159.
[Abstract] [PDF]

Home page
 CirculationHome page
C. G. De Pasquale, L. F. Arnolda, I. R. Doyle, P. E. Aylward, D. P. Chew, and A. D. Bersten
Plasma Surfactant Protein-B: A Novel Biomarker in Chronic Heart Failure
Circulation, August 31, 2004; 110(9): 1091 - 1096.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Hirsch, K. C. Hansen, A. L. Burlingame, and M. A. Matthay
Proteomics: current techniques and potential applications to lung disease
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L1 - L23.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. P. Bowler, B. Duda, E. D. Chan, J. J. Enghild, L. B. Ware, M. A. Matthay, and M. W. Duncan
Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1095 - L1104.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Zagorski, J. Debelak, M. Gellar, J. A. Watts, and J. A. Kline
Chemokines Accumulate in the Lungs of Rats with Severe Pulmonary Embolism Induced by Polystyrene Microspheres
J. Immunol., November 15, 2003; 171(10): 5529 - 5536.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M D Eisner, P Parsons, M A Matthay, L Ware, and K Greene
Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury
Thorax, November 1, 2003; 58(11): 983 - 988.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
A Bernard, S Carbonnelle, O Michel, S Higuet, C de Burbure, J-P Buchet, C Hermans, X Dumont, and I Doyle
Lung hyperpermeability and asthma prevalence in schoolchildren: unexpected associations with the attendance at indoor chlorinated swimming pools
Occup. Environ. Med., June 1, 2003; 60(6): 385 - 394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. G. De Pasquale, A. D. Bersten, I. R. Doyle, P. E. Aylward, and L. F. Arnolda
Infarct-induced chronic heart failure increases bidirectional protein movement across the alveolocapillary barrier
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2136 - H2145.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J F Seymour, I R Doyle, K Nakata, J J Presneill, O D Schoch, E Hamano, K Uchida, R Fisher, and A R Dunn
Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in patients with idiopathic alveolar proteinosis
Thorax, March 1, 2003; 58(3): 252 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. Lesur, C. Hermans, J.-F. Chalifour, J. Picotte, B. Levy, A. Bernard, and D. Lane
Mechanical ventilation-induced pneumoprotein CC-16 vascular transfer in rats: effect of KGF pretreatment
Am J Physiol Lung Cell Mol Physiol, February 1, 2003; 284(2): L410 - L419.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Robin, P. Dong, C. Hermans, A. Bernard, A.D. Bersten, and I.R. Doyle
Serum levels of CC16, SP-A and SP-B reflect tobacco-smoke exposure in asymptomatic subjects
Eur. Respir. J., November 1, 2002; 20(5): 1152 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. A. Gutierrez, A. J. Parry, D. M. McMullan, C. J. Chapin, and J. R. Fineman
Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow
Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1264 - L1270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. D. BERSTEN, T. HUNT, T. E. NICHOLAS, and I. R. DOYLE
Elevated Plasma Surfactant Protein-B Predicts Development of Acute Respiratory Distress Syndrome in Patients with Acute Respiratory Failure
Am. J. Respir. Crit. Care Med., August 15, 2001; 164(4): 648 - 652.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. P. Ingenito, R. Mora, M. Cullivan, Y. Marzan, K. Haley, L. Mark, and L. A. Sonna
Decreased Surfactant Protein-B Expression and Surfactant Dysfunction in a Murine Model of Acute Lung Injury
Am. J. Respir. Cell Mol. Biol., July 1, 2001; 25(1): 35 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. F. Herbein and J. R. Wright
Enhanced clearance of surfactant protein D during LPS-induced acute inflammation in rat lung
Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L268 - L277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. F. SEYMOUR, J. J. PRESNEILL, O. D. SCHOCH, G. H. DOWNIE, P. E. MOORE, I. R. DOYLE, J. M. VINCENT, K. NAKATA, T. KITAMURA, D. LANGTON, et al.
Therapeutic Efficacy of Granulocyte-Macrophage Colony-Stimulating Factor in Patients with Idiopathic Acquired Alveolar Proteinosis
Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 524 - 531.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. G. Davidson, A. D. Bersten, H. A. Barr, K. D. Dowling, T. E. Nicholas, and I. R. Doyle
Lung function, permeability, and surfactant composition in oleic acid-induced acute lung injury in rats
Am J Physiol Lung Cell Mol Physiol, December 1, 2000; 279(6): L1091 - L1102.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. E. GREENE, J. R. WRIGHT, K. P. STEINBERG, J. T. RUZINSKI, E. CALDWELL, W. B. WONG, W. HULL, J. A. WHITSETT, T. AKINO, Y. KUROKI, et al.
Serial Changes in Surfactant-associated Proteins in Lung and Serum before and after Onset of ARDS
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 1843 - 1850.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. HERMANS and A. BERNARD
Lung Epithelium-specific Proteins . Characteristics and Potential Applications as Markers
Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 646 - 678.
[Full Text]

Home page
 J. Exp. Biol.Home page
J. Power, I. Doyle, K Davidson, and T. Nicholas
Ultrastructural and protein analysis of surfactant in the Australian lungfish Neoceratodus forsteri: evidence for conservation of composition for 300 million years
J. Exp. Biol., January 9, 1999; 202(18): 2543 - 2550.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. R. DOYLE, C. HERMANS, A. BERNARD, T. E. NICHOLAS, and A. D. BERSTEN
Clearance of Clara Cell Secretory Protein 16 (CC16) and Surfactant Proteins A and B from Blood in Acute Respiratory Failure
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(5): 1528 - 1535.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1997 American Thoracic Society 		  ATS Coding and Billing Quarterly