Am. J. Respir. Crit. Care Med.,
Volume 156, Number 4, October 1997, 1197-1204
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105 CFU/ml) infection; and the remaining 18 had either respiratory symptoms, taken antibiotics, or had < 105 CFU/ml of respiratory pathogens.
Their BAL cytology, interleukin-8, and elastolytic activity were compared with those from 13 control subjects. In a longitudinal study to assess if inflammation develops or persists in the absence of infection, the results of 56 paired annual BAL specimens from 44 CF infants were grouped according to
whether they showed absence, development, clearance, or persistence of infection. In newly diagnosed infants with CF, those without infection had BAL profiles comparable with control subjects
while those with a lower respiratory infection had evidence of airway inflammation. In older children,
the development and persistence of infection was accompanied by increased inflammatory markers, whereas these were decreased in the absence, or with the clearance, of infection. We conclude that
airway inflammation follows respiratory infection and, in young children, improves when pathogens
are eradicated from the airways.
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T. M. Martinez, C. J. Llapur, T. H. Williams, C. Coates, R. Gunderman, M. D. Cohen, M. S. Howenstine, O. Saba, H. O. Coxson, and R. S. Tepper High-Resolution Computed Tomography Imaging of Airway Disease in Infants with Cystic Fibrosis Am. J. Respir. Crit. Care Med., November 1, 2005; 172(9): 1133 - 1138. [Abstract] [Full Text] [PDF]
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A. L. Griffiths, K. Jamsen, J. B. Carlin, K. Grimwood, R. Carzino, P. J. Robinson, J. Massie, and D. S. Armstrong Effects of Segregation on an Epidemic Pseudomonas aeruginosa Strain in a Cystic Fibrosis Clinic Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 1020 - 1025. [Abstract] [Full Text] [PDF]
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M. Griese, R. Essl, R. Schmidt, E. Rietschel, F. Ratjen, M. Ballmann, K. Paul, and for the BEAT Study Group Pulmonary Surfactant, Lung Function, and Endobronchial Inflammation in Cystic Fibrosis Am. J. Respir. Crit. Care Med., November 1, 2004; 170(9): 1000 - 1005. [Abstract] [Full Text] [PDF]
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U. Pradal and G. L. Piacentini Cystic Fibrosis Patients, Infertile Men, and Their Noses Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 141 - 142. [Full Text] [PDF]
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M. Gilljam, Y. Moltyaner, G. P. Downey, R. Devlin, P. Durie, A. M. Cantin, J. Zielenski, and D. E. Tullis Airway Inflammation and Infection in Congenital Bilateral Absence of the Vas Deferens Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 174 - 179. [Abstract] [Full Text] [PDF]
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D. S. Armstrong In Celebration of Expectoration: Induced Sputum Indices as Outcome Measures in Cystic Fibrosis Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1412 - 1413. [Full Text] [PDF]
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C. L. Ordonez, N. R. Henig, N. Mayer-Hamblett, F. J. Accurso, J. L. Burns, J. F. Chmiel, C. L. Daines, R. L. Gibson, S. McNamara, G. Z. Retsch-Bogart, et al. Inflammatory and Microbiologic Markers in Induced Sputum after Intravenous Antibiotics in Cystic Fibrosis Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1471 - 1475. [Abstract] [Full Text] [PDF]
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P.M. Gustafsson, P. Aurora, and A. Lindblad Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis Eur. Respir. J., December 1, 2003; 22(6): 972 - 979. [Abstract] [Full Text] [PDF]
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R. L. Gibson, J. L. Burns, and B. W. Ramsey Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 918 - 951. [Abstract] [Full Text] [PDF]
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J. Gerritsen Flexible bronchoscopy in children: an open airway Eur. Respir. J., October 1, 2003; 22(4): 576 - 577. [Full Text] [PDF]
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H. L. Wallace, P. M. Barker, and K. W. Southern Nasal Airway Ion Transport and Lung Function in Young People with Cystic Fibrosis Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 594 - 600. [Abstract] [Full Text] [PDF]
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R. L. Gibson, J. Emerson, S. McNamara, J. L. Burns, M. Rosenfeld, A. Yunker, N. Hamblett, F. Accurso, M. Dovey, P. Hiatt, et al. Significant Microbiological Effect of Inhaled Tobramycin in Young Children with Cystic Fibrosis Am. J. Respir. Crit. Care Med., March 15, 2003; 167(6): 841 - 849. [Abstract] [Full Text] [PDF]
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S. C. Ranganathan, A. Bush, C. Dezateux, S. B. Carr, A.-F. Hoo, S. Lum, S. Madge, J. Price, J. Stroobant, A. Wade, et al. Relative Ability of Full and Partial Forced Expiratory Maneuvers to Identify Diminished Airway Function in Infants with Cystic Fibrosis Am. J. Respir. Crit. Care Med., November 15, 2002; 166(10): 1350 - 1357. [Abstract] [Full Text] [PDF]
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N. Aldallal, E. E. McNaughton, L. J. Manzel, A. M. Richards, J. Zabner, T. W. Ferkol, and D. C. Look Inflammatory Response in Airway Epithelial Cells Isolated from Patients with Cystic Fibrosis Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1248 - 1256. [Abstract] [Full Text] [PDF]
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D. S. Armstrong, G. M. Nixon, R. Carzino, A. Bigham, J. B. Carlin, R. M. Robins-Browne, and K. Grimwood Detection of a Widespread Clone of Pseudomonas aeruginosa in a Pediatric Cystic Fibrosis Clinic Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 983 - 987. [Abstract] [Full Text]
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R. S. Smith, R. Kelly, B. H. Iglewski, and R. P. Phipps The Pseudomonas Autoinducer N-(3-Oxododecanoyl) Homoserine Lactone Induces Cyclooxygenase-2 and Prostaglandin E2 Production in Human Lung Fibroblasts: Implications for Inflammation J. Immunol., September 1, 2002; 169(5): 2636 - 2642. [Abstract] [Full Text] [PDF]
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R. Tirouvanziam, I. Khazaal, and B. Peault Primary inflammation in human cystic fibrosis small airways Am J Physiol Lung Cell Mol Physiol, August 1, 2002; 283(2): L445 - L451. [Abstract] [Full Text] [PDF]
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P. J. C. Marostica, A. D. Weist, H. Eigen, C. Angelicchio, K. Christoph, J. Savage, D. Grant, and R. S. Tepper Spirometry in 3- to 6-Year-Old Children with Cystic Fibrosis Am. J. Respir. Crit. Care Med., July 1, 2002; 166(1): 67 - 71. [Abstract] [Full Text] [PDF]
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M. Berger Lung Inflammation Early in Cystic Fibrosis . Bugs Are Indicted, But the Defense Is Guilty Am. J. Respir. Crit. Care Med., April 1, 2002; 165(7): 857 - 858. [Full Text] [PDF]
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C. J. DAKIN, A. H. NUMA, H. WANG, J. R. MORTON, C. C. VERTZYAS, and R. L. HENRY Inflammation, Infection, and Pulmonary Function in Infants and Young Children with Cystic Fibrosis Am. J. Respir. Crit. Care Med., April 1, 2002; 165(7): 904 - 910. [Abstract] [Full Text] [PDF]
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S. D. SAGEL, R. KAPSNER, I. OSBERG, M. K. SONTAG, and F. J. ACCURSO Airway Inflammation in Children with Cystic Fibrosis and Healthy Children Assessed by Sputum Induction Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1425 - 1431. [Abstract] [Full Text] [PDF]
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M.E. Merelle, J.P. Schouten, J. Gerritsen, and J.E. Dankert-Roelse Influence of neonatal screening and centralized treatment on long-term clinical outcome and survival of CF patients Eur. Respir. J., August 1, 2001; 18(2): 306 - 315. [Abstract] [Full Text] [PDF]
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I. J M Doull Recent advances: Recent advances in cystic fibrosis Arch. Dis. Child., July 1, 2001; 85(1): 62 - 66. [Abstract] [Full Text] [PDF]
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 Y. Y. Koh, Y. Park, H. J. Lee, and C. K. Kim Levels of Interleukin-2, Interferon-{gamma}, and Interleukin-4 in Bronchoalveolar Lavage Fluid From Patients With Mycoplasma Pneumonia: Implication of Tendency Toward Increased Immunoglobulin E Production Pediatrics, March 1, 2001; 107(3): 39e - 39. [Abstract] [Full Text]
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J.P. Gutierrez, K. Grimwood, D.S. Armstrong, J.B. Carlin, R. Carzino, A. Olinsky, C.F. Robertson, and P.D. Phelan Interlobar differences in bronchoalveolar lavage fluid from children with cystic fibrosis Eur. Respir. J., February 1, 2001; 17(2): 281 - 286. [Abstract] [Full Text] [PDF]
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P. Scheid, L. Kempster, U. Griesenbach, J.C. Davies, A. Dewar, P.P. Weber, W.H. Colledge, M.J. Evans, D.M. Geddes, and E.W.F.W. Alton Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence Eur. Respir. J., January 1, 2001; 17(1): 27 - 35. [Abstract] [Full Text] [PDF]
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R. Tirouvanziam, S. de Bentzmann, C. Hubeau, J. Hinnrasky, J. Jacquot, B. Péault, and E. Puchelle Inflammation and Infection in Naive Human Cystic Fibrosis Airway Grafts Am. J. Respir. Cell Mol. Biol., August 1, 2000; 23(2): 121 - 127. [Abstract] [Full Text]
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A. BUSH, H. TIDDENS, and M. SILVERMAN Clinical Implications of Inflammation in Young Children Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): S11 - 14. [Full Text] [PDF]
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A. BUSH and P. POHUNEK Brush Biopsy and Mucosal Biopsy Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): S18 - 22. [Full Text] [PDF]
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 J. Ben-Ari, D. Gozal, R. J. Dorio, C. M. Bowman, A. Reiff, and S. M. Walker Superantigens and Cystic Fibrosis: Resistance of Presenting Cells to Dexamethasone Clin. Vaccine Immunol., July 1, 2000; 7(4): 553 - 556. [Abstract] [Full Text] [PDF]
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 L. Pizurki, M. A. Morris, M. Chanson, M. Solomon, A. Pavirani, I. Bouchardy, and S. Suter Cystic Fibrosis Transmembrane Conductance Regulator Does Not Affect Neutrophil Migration across Cystic Fibrosis Airway Epithelial Monolayers Am. J. Pathol., April 1, 2000; 156(4): 1407 - 1416. [Abstract] [Full Text] [PDF]
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C. Taggart, R. J. Coakley, P. Greally, G. Canny, S. J. O'Neill, and N. G. McElvaney Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8 Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L33 - L41. [Abstract] [Full Text] [PDF]
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L. C. Lands, V. Grey, A. A. Smountas, V. G. Kramer, and D. McKenna Lymphocyte Glutathione Levels in Children With Cystic Fibrosis Chest, July 1, 1999; 116(1): 201 - 205. [Abstract] [Full Text] [PDF]
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M. S. MUHLEBACH, P. W. STEWART, M. W. LEIGH, and T. L. NOAH Quantitation of Inflammatory Responses to Bacteria in Young Cystic Fibrosis and Control Patients Am. J. Respir. Crit. Care Med., July 1, 1999; 160(1): 186 - 191. [Abstract] [Full Text]
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L. M. Schwiebert, K. Estell, and S. M. Propst Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression Am J Physiol Cell Physiol, March 1, 1999; 276(3): C700 - C710. [Abstract] [Full Text] [PDF]
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 J. M. PILEWSKI and R. A. FRIZZELL Role of CFTR in Airway Disease Physiol Rev, January 1, 1999; 79(1): 215 - 255. [Abstract] [Full Text] [PDF]
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H. R. Black, J. R. Yankaskas, L. G. Johnson, and T. L. Noah Interleukin-8 Production by Cystic Fibrosis Nasal Epithelial Cells after Tumor Necrosis Factor-alpha and Respiratory Syncytial Virus Stimulation Am. J. Respir. Cell Mol. Biol., August 1, 1998; 19(2): 210 - 215. [Abstract] [Full Text]
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