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Am. J. Respir. Crit. Care Med., Volume 156, Number 3, September 1997, 968-973

Transforming Growth Factor beta 1, Interleukin-8 and Interleukin-1, in Non-Small-Cell Lung Tumors

ANTONELLA COLASANTE, NICOLA MASCETRA, MAURO BRUNETTI, GIUSEPPE LATTANZIO, MARIAGRAZIA DIODORO, SARA CALTAGIRONE, PIERO MUSIANI, and FRANCESCA B. AIELLO

Department of Pathology, "G. D'Annunzio" University, Chieti; and Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy

A role in tumor progression has been proposed for transforming growth fractor-beta 1 (TGFbeta 1) and interleukin (IL)-8 as well as for IL-1, which itself induces the production of TGFbeta 1 and IL-8 in many cell types. TGFbeta 1 and IL-8 production and their regulation by IL-1 in five non-small-cell (NSC) lung tumor cell lines were evaluated. Moreover, their levels were evaluated in 29 NSC lung tumors. All cell lines constitutively produced TGFbeta 1, and three produced IL-8. After IL-1beta treatment, TGFbeta 1 production was upregulated in two cell lines, whereas IL-8 production was markedly upregulated in two, induced in one, and unmodified in two. In tumors, the levels of TGFbeta 1, IL-8, and IL-1beta were higher than in normal counterparts (p < 0.001), and a positive correlation between IL-8 and IL-1beta levels (p < 0.001) was found. TGFbeta 1, IL-8, and IL-1beta mRNA expression was examined in 12 tumors. TGFbeta 1 mRNA was detected in all cases, IL-8 mRNA in 7, and IL-1beta MRNA was undetectable. TGFbeta 1, IL-8, and IL-1beta immunoreactivity was then studied by immunohistochemistry. TGFbeta 1 and IL-8 immunoreactivity was observed in neoplastic cells; IL-1beta immunoreactivity was observed in mononuclear cells. In conclusion, in tumors IL-1beta levels positively correlated with those of IL-8, and IL-1beta as well as TGFbeta 1 and IL-8 levels were significantly higher than in normal tissues.




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