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Am. J. Respir. Crit. Care Med., Volume 156, Number 3, September 1997, 939-942

Factors Influencing Survival in Children with Chronic Interstitial Lung Disease

LELAND L. FAN and CLAUDIA A. KOZINETZ

Pediatric Pulmonary Section, and Academic General Pediatric Section, Baylor College of Medicine, Houston, Texas

To investigate factors influencing survival in children with chronic interstitial lung disease (ILD), we extracted specific clinical information from a data base of 99 children with ILD who met entry criteria for our study. The effects of a weight below the fifth percentile for the patient's age, crackles, clubbing, family history of ILD, symptom duration, and severity-of-illness score on survival were examined with univariate and multivariate statistical analyses. There were 15 recorded deaths in the group, with a probability that a patient would survive to 24 mo, 48 mo, and 60 mo after onset of symptoms of 83%, 72%, and 64%, respectively. Of the clinical features, only increasing severity-of-illness score was significantly associated with a higher probability of decreased survival. Children with ILD have decreased survival probabilities that can be predicted with a severity-of-illness score.




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