Am. J. Respir. Crit. Care Med., Volume 156, Number 3, September 1997, 783-786

Reduced Airway Absorption in Seasonal Allergic Rhinitis

LENNART GREIFF, MORGAN ANDERSSON, CHRISTER SVENSSON, STEFAN LUNDIN, PER WOLLMER, and CARL G. A. PERSSON

Departments of Otorhinolaryngology, Head and Neck Surgery and Clinical Pharmacology, University Hospital, Lund; and Department of Clinical Physiology, University Hospital MAS, Malmö, Sweden

The common notion that increased mucosal absorption characterizes allergic and inflamed airways is poorly supported by physiologic in vivo data. We have now examined whether the airway mucosa of patients with seasonal allergic rhinitis develop a change in absorption during their active disease period. Twelve patients with birch pollen rhinitis were examined twice, prior to and late into a Swedish birch pollen season. Ten healthy subjects were examined once. A nasal pool device was used to fill the unilateral nasal cavity with fluid containing 1-deamino-8-D-arginine vasopressin (desmopressin, 20 µg/ml) as absorption tracer. The peptide tracer solution was removed after 15 min, and absorption was determined by analysis of the peptide in the 24-h urine sample. Nasal absorption did not differ between healthy subjects and symptom-free patients outside the season. After 3 wk of symptom-producing seasonal allergic rhinitis, absorption of the peptide across the nasal mucosa was less (p < 0.05) than outside the season. These data indicate that hyperresponsiveness and disease progression in seasonal allergic rhinitis are not due to a compromise of the mucosal barrier that would permit increased absorption of mucosally deposited solutes. The reduced absorption may in part reflect the ability of the airway epithelium in vivo to maintain and potentially improve its barrier function by efficient epithelial restitution processes.