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Am. J. Respir. Crit. Care Med., Volume 156, Number 2, August 1997, 665-668

Bronchiolitis Obliterans and IgA Nephropathy
A New Cause of Pulmonary-Renal Syndrome

JOSÉ L. HERNÁNDEZ, JAVIER GÓMEZ-ROMÁN, EMILIO RODRIGO, JOSÉ M. OLMOS, CARMEN GONZÁLEZ-VELA, JUAN C. RUIZ, JOSÉ F. VAL, and JOSÉ A. RIANCHO

Department of Internal Medicine, Department of Pathology, and Division of Nephrology, Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain

IgA nephropathy is a common form of glomerulonephritis, classically manifested by asymptomatic hematuria. Although the exact pathophysiologic mechanism is still unknown, renal damage has been related to mesangial deposition of IgA-containing immune complexes. In recent years, some lung diseases have been associated with IgA nephropathy, including pulmonary hemorrhage and sarcoidosis. We report a patient with idiopathic bronchiolitis obliterans who developed a rapidly progressive glomerulonephritis due to IgA deposits. Extensive deposits of IgA were also found in the lungs, thus suggesting a pathogenetic role for IgA in tissue injury at both organ levels. To our knowledge this association has not been previously described in the literature.






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Copyright © 1997 American Thoracic Society 		  Tobacco