help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CASSART, M.
Right arrow Articles by ESTENNE, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CASSART, M.
Right arrow Articles by ESTENNE, M.

Am. J. Respir. Crit. Care Med., Volume 156, Number 2, August 1997, 504-508

Effect of Chronic Hyperinflation on Diaphragm Length and Surface Area

MARIE CASSART, NICOLAS PETTIAUX, PIERRE ALAIN GEVENOIS, MANUEL PAIVA, and MARC ESTENNE

Service of Radiology, Biomedical Physics Laboratory, and Service of Chest Medicine, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium

We have used three-dimensional reconstructions obtained with spiral computed tomography to measure total diaphragm length (Ldi) and surface area (Adi), the length (Ldo) and surface area (Ado) of the dome, and the length (Lap) and surface area (Aap) of the zone of apposition in 10 hyperinflated patients with severe chronic obstructive pulmonary disease, or COPD (FEV1 = 27% predicted: FRC = 225% predicted) and 10 normal subjects matched for age, sex, and height. Measures of Ldi, Adi, Lap, and Aap decreased linearly between FRC and TLC in the two groups, but Ldo and Ado did not change. On average, patients' Adi and Aap at FRC were reduced to 73% and 54% of normal values, whereas Ado was unaffected. When compared at similar absolute lung volumes, mean diaphragm dimensions were similar in patients with COPD and normal subjects, but individual values were very variable in both groups. This variability was partly accounted for by differences in body weight: i.e., the greater the weight, the longer the diaphragm. We conclude that (1) patients with COPD have marked reductions in Adi and Aap at FRC but have diaphragm dimensions similar to those of normal subjects when compared at similar absolute lung volumes, and (2) normal subjects and patients with COPD show substantial intersubject variability in diaphragm dimensions that is partly explained by differences in body weight.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. Estenne
Effect of lung transplant and volume reduction surgery on respiratory muscle function
J Appl Physiol, September 1, 2009; 107(3): 977 - 986.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Tobin, F. Laghi, and L. Brochard
Role of the respiratory muscles in acute respiratory failure of COPD: lessons from weaning failure
J Appl Physiol, September 1, 2009; 107(3): 962 - 970.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. K. McKenzie, J. E. Butler, and S. C. Gandevia
Respiratory muscle function and activation in chronic obstructive pulmonary disease
J Appl Physiol, August 1, 2009; 107(2): 621 - 629.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. L. Clanton and S. Levine
Respiratory muscle fiber remodeling in chronic hyperinflation: dysfunction or adaptation?
J Appl Physiol, July 1, 2009; 107(1): 324 - 335.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
C. J. Jolley and J. Moxham
A physiological model of patient-reported breathlessness during daily activities in COPD
Eur. Respir. Rev., June 1, 2009; 18(112): 66 - 79.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Bellemare and A. Jeanneret
Sex differences in thoracic adaptation to pulmonary hyperinflation in cystic fibrosis
Eur. Respir. J., January 1, 2007; 29(1): 98 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. J. Moore, A. Stubbings, E. B. Swallow, M. Dusmet, P. Goldstraw, R. Porcher, J. Moxham, M. I. Polkey, and M. A. Ferenczi
Passive properties of the diaphragm in COPD
J Appl Physiol, November 1, 2006; 101(5): 1400 - 1405.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. A. C. Ottenheijm, L. M. A. Heunks, Y.-P. Li, B. Jin, R. Minnaard, H. W. H. van Hees, and P. N. R. Dekhuijzen
Activation of the Ubiquitin-Proteasome Pathway in the Diaphragm in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., November 1, 2006; 174(9): 997 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. E. O'Donnell
Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.
Proceedings of the ATS, January 1, 2006; 3(2): 180 - 184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. B. Gorman, D. K. McKenzie, J. E. Butler, J. F. Tolman, and S. C. Gandevia
Diaphragm Length and Neural Drive after Lung Volume Reduction Surgery
Am. J. Respir. Crit. Care Med., November 15, 2005; 172(10): 1259 - 1266.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
C Pinet, P Scillia, M Cassart, M Lamotte, C Knoop, C Melot, and M Estenne
Preferential reduction of quadriceps over respiratory muscle strength and bulk after lung transplantation for cystic fibrosis
Thorax, September 1, 2004; 59(9): 783 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Orozco-Levi
Structure and function of the respiratory muscles in patients with COPD: impairment or adaptation?
Eur. Respir. J., November 2, 2003; 22(46_suppl): 41s - 51s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. Pinet, M. Cassart, P. Scillia, M. Lamotte, C. Knoop, G. Casimir, C. Melot, and M. Estenne
Function and Bulk of Respiratory and Limb Muscles in Patients with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 989 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Bellemare, A. Jeanneret, and J. Couture
Sex Differences in Thoracic Dimensions and Configuration
Am. J. Respir. Crit. Care Med., August 1, 2003; 168(3): 305 - 312.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Laghi and M. J. Tobin
Disorders of the Respiratory Muscles
Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 10 - 48.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Singh, J. A. Panizza, and K. E. Finucane
Breath-by-breath measurement of the volume displaced by diaphragm motion
J Appl Physiol, March 1, 2003; 94(3): 1084 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. B. Gorman, D. K. McKenzie, N. B. Pride, J. F. Tolman, and S. C. Gandevia
Diaphragm Length during Tidal Breathing in Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1461 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. Bellemare, M.-P. Cordeau, J. Couture, E. Lafontaine, P. Leblanc, and L. Passerini
Effects of Emphysema and Lung Volume Reduction Surgery on Transdiaphragmatic Pressure and Diaphragm Length*
Chest, June 1, 2002; 121(6): 1898 - 1910.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Iwasawa, S. Kagei, T. Gotoh, Y. Yoshiike, K. Matsushita, H. Kurihara, K. Saito, and S. Matsubara
Magnetic resonance analysis of abnormal diaphragmatic motion in patients with emphysema
Eur. Respir. J., February 1, 2002; 19(2): 225 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G.R. Ferretti, I. Bricault, and M. Coulomb
Virtual tools for imaging of the thorax
Eur. Respir. J., August 1, 2001; 18(2): 381 - 392.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. Bellemare, J. Couture, M.-P. Cordeau, P. Leblanc, and E. Lafontaine
Anatomic Landmarks To Estimate the Length of the Diaphragm From Chest Radiographs : Effects of Emphysema and Lung Volume Reduction Surgery
Chest, August 1, 2001; 120(2): 444 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. SINDERBY, J. SPAHIJA, J. BECK, D. KAMINSKI, S. YAN, N. COMTOIS, and P. SLIWINSKI
Diaphragm Activation during Exercise in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1637 - 1641.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H.U. Kauczor, X.J. Chen, E.J.R. van Beek, and W.G. Schreiber
Pulmonary ventilation imaged by magnetic resonance: at the doorstep of clinical application
Eur. Respir. J., May 1, 2001; 17(5): 1008 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. G. Hoppin Jr.
Hyperinflation and the (Passive) Chest Wall
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1042 - 1043.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. CASSART, J. HAMACHER, Y. VERBANDT, S. WILDERMUTH, D. RITSCHER, E. W. RUSSI, P. de FRANCQUEN, M. CAPPELLO, W. WEDER, and M. ESTENNE
Effects of Lung Volume Reduction Surgery for Emphysema on Diaphragm Dimensions and Configuration
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1171 - 1175.
[Abstract] [Full Text]

Home page
 ChestHome page
M. I. Polkey and J. Moxham
Clinical Aspects of Respiratory Muscle Dysfunction in the Critically Ill
Chest, March 1, 2001; 119(3): 926 - 939.
[Full Text] [PDF]

Home page
 ChestHome page
K. Suga, T. Tsukuda, H. Awaya, N. Matsunaga, K. Sugi, and K. Esato
Interactions of Regional Respiratory Mechanics and Pulmonary Ventilatory Impairment in Pulmonary Emphysema : Assessment With Dynamic MRI and Xenon-133 Single-Photon Emission CT
Chest, June 1, 2000; 117(6): 1646 - 1655.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
P. Cluzel, T. Similowski, C. Chartrand-Lefebvre, M. Zelter, J.-P. Derenne, and P. A. Grenier
Diaphragm and Chest Wall: Assessment of the Inspiratory Pump with MR Imaging-Preliminary Observations
Radiology, May 1, 2000; 215(2): 574 - 583.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. CASSART, Y. VERBANDT, P. de FRANCQUEN, P. A. GEVENOIS, and M. ESTENNE
Diaphragm Dimensions After Single-Lung Transplantation for Emphysema
Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1992 - 1997.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. ESTENNE, M. CASSART, P. PONCELET, and P. A. GEVENOIS
Volume of Graft and Native Lung after Single-Lung Transplantation for Emphysema
Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 641 - 645.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1997 American Thoracic Society 		  New Orleans Int'l Conf