Am. J. Respir. Crit. Care Med.,
Volume 156, Number 1, July 1997, 240-247
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D. M. Brass, J. W. Hollingsworth, M. Cinque, Z. Li, E. Potts, E. Toloza, W. M. Foster, and D. A. Schwartz Chronic LPS Inhalation Causes Emphysema-Like Changes in Mouse Lung that Are Associated with Apoptosis Am. J. Respir. Cell Mol. Biol., November 1, 2008; 39(5): 584 - 590. [Abstract] [Full Text] [PDF] |
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Y. Takeda, P. He, I. Tachibana, B. Zhou, K. Miyado, H. Kaneko, M. Suzuki, S. Minami, T. Iwasaki, S. Goya, et al. Double Deficiency of Tetraspanins CD9 and CD81 Alters Cell Motility and Protease Production of Macrophages and Causes Chronic Obstructive Pulmonary Disease-like Phenotype in Mice J. Biol. Chem., September 19, 2008; 283(38): 26089 - 26097. [Abstract] [Full Text] [PDF] |
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S. Togo, O. Holz, X. Liu, H. Sugiura, K. Kamio, X. Wang, S. Kawasaki, Y. Ahn, K. Fredriksson, C. M. Skold, et al. Lung Fibroblast Repair Functions in Patients with Chronic Obstructive Pulmonary Disease Are Altered by Multiple Mechanisms Am. J. Respir. Crit. Care Med., August 1, 2008; 178(3): 248 - 260. [Abstract] [Full Text] [PDF] |
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K. F. Chung and I. M. Adcock Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction Eur. Respir. J., June 1, 2008; 31(6): 1334 - 1356. [Abstract] [Full Text] [PDF] |
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R. Foronjy, T. Nkyimbeng, A. Wallace, J. Thankachen, Y. Okada, V. Lemaitre, and J. D'Armiento Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin Am J Physiol Lung Cell Mol Physiol, June 1, 2008; 294(6): L1149 - L1157. [Abstract] [Full Text] [PDF] |
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V. Kim, T. J. Rogers, and G. J. Criner New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, May 1, 2008; 5(4): 478 - 485. [Abstract] [Full Text] [PDF] |
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A. Churg, M. Cosio, and J. L. Wright Mechanisms of cigarette smoke-induced COPD: insights from animal models Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L612 - L631. [Abstract] [Full Text] [PDF] |
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G. M. Turino Proteases in COPD: A Critical Pathway to Injury Chest, December 1, 2007; 132(6): 1724 - 1725. [Full Text] [PDF] |
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S. Baraldo, E. Bazzan, M. E. Zanin, G. Turato, S. Garbisa, P. Maestrelli, A. Papi, M. Miniati, L. M. Fabbri, R. Zuin, et al. Matrix Metalloproteinase-2 Protein in Lung Periphery Is Related to COPD Progression Chest, December 1, 2007; 132(6): 1733 - 1740. [Abstract] [Full Text] [PDF] |
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J. Bourbeau, P. Christodoulopoulos, F. Maltais, Y. Yamauchi, R. Olivenstein, and Q. Hamid Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial Thorax, November 1, 2007; 62(11): 938 - 943. [Abstract] [Full Text] [PDF] |
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L. Plantier, S. Marchand-Adam, V. G. Antico, L. Boyer, C. De Coster, J. Marchal, R. Bachoual, A. Mailleux, J. Boczkowski, and B. Crestani Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1230 - L1239. [Abstract] [Full Text] [PDF] |
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E. L. Martin, T. A. Sheikh, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L779 - L789. [Abstract] [Full Text] [PDF] |
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A. Churg, R. Wang, X. Wang, P.-O. Onnervik, K. Thim, and J. L Wright Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs Thorax, August 1, 2007; 62(8): 706 - 713. [Abstract] [Full Text] [PDF] |
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W. Ning, Y. Dong, J. Sun, C. Li, M. A. Matthay, C. A. Feghali-Bostwick, and A. M. K. Choi Cigarette Smoke Stimulates Matrix Metalloproteinase-2 Activity via EGR-1 in Human Lung Fibroblasts Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 480 - 490. [Abstract] [Full Text] [PDF] |
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A. Shifren, A. G. Durmowicz, R. H. Knutsen, E. Hirano, and R. P. Mecham Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L778 - L787. [Abstract] [Full Text] [PDF] |
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D. G. Morris and D. Sheppard Pulmonary Emphysema: When More is Less. Physiology, December 1, 2006; 21(6): 396 - 403. [Abstract] [Full Text] [PDF] |
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G M Turino Emphysema in COPD: consequences and causes. Thorax, December 1, 2006; 61(12): 1031 - 1036. [Full Text] [PDF] |
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P Boschetto, S Quintavalle, E Zeni, S Leprotti, A Potena, L Ballerin, A Papi, G Palladini, M Luisetti, L Annovazzi, et al. Association between markers of emphysema and more severe chronic obstructive pulmonary disease Thorax, December 1, 2006; 61(12): 1037 - 1042. [Abstract] [Full Text] [PDF] |
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K. Ueda, M. Jinbo, T.-S. Li, T. Yagi, K. Suga, and K. Hamano Computed Tomography-Diagnosed Emphysema, Not Airway Obstruction, Is Associated with the Prognostic Outcome of Early-Stage Lung Cancer. Clin. Cancer Res., November 15, 2006; 12(22): 6730 - 6736. [Abstract] [Full Text] [PDF] |
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R O'Donnell, D Breen, S Wilson, and R Djukanovic Inflammatory cells in the airways in COPD Thorax, May 1, 2006; 61(5): 448 - 454. [Abstract] [Full Text] [PDF] |
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R. Vlahos, S. Bozinovski, J. E. Jones, J. Powell, J. Gras, A. Lilja, M. J. Hansen, R. C. Gualano, L. Irving, and G. P. Anderson Differential protease, innate immunity, and NF-{kappa}B induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L931 - L945. [Abstract] [Full Text] [PDF] |
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R. F. Foronjy, O. Mirochnitchenko, O. Propokenko, V. Lemaitre, Y. Jia, M. Inouye, Y. Okada, and J. M. D'Armiento Superoxide Dismutase Expression Attenuates Cigarette Smoke- or Elastase-generated Emphysema in Mice Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 623 - 631. [Abstract] [Full Text] [PDF] |
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P T G Elkington and J S Friedland Matrix metalloproteinases in destructive pulmonary pathology Thorax, March 1, 2006; 61(3): 259 - 266. [Abstract] [Full Text] [PDF] |
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K. Fredriksson, X. D. Liu, J. Lundahl, J. Klominek, S. I. Rennard, and C. M. Skold Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L326 - L333. [Abstract] [Full Text] [PDF] |
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P. T. G. Elkington, R. K. Nuttall, J. J. Boyle, C. M. O'Kane, D. E. Horncastle, D. R. Edwards, and J. S. Friedland Mycobacterium tuberculosis, but Not Vaccine BCG, Specifically Upregulates Matrix Metalloproteinase-1 Am. J. Respir. Crit. Care Med., December 15, 2005; 172(12): 1596 - 1604. [Abstract] [Full Text] [PDF] |
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I. Ito, S. Nagai, T. Handa, S. Muro, T. Hirai, M. Tsukino, and M. Mishima Matrix Metalloproteinase-9 Promoter Polymorphism Associated with Upper Lung Dominant Emphysema Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1378 - 1382. [Abstract] [Full Text] [PDF] |
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P. G. Woodruff, L. L. Koth, Y. H. Yang, M. W. Rodriguez, S. Favoreto, G. M. Dolganov, A. C. Paquet, and D. J. Erle A Distinctive Alveolar Macrophage Activation State Induced by Cigarette Smoking Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1383 - 1392. [Abstract] [Full Text] [PDF] |
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W. MacNee Pathogenesis of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2005; 2(4): 258 - 266. [Abstract] [Full Text] [PDF] |
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C. A. Owen Proteinases and Oxidants as Targets in the Treatment of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2005; 2(4): 373 - 385. [Abstract] [Full Text] [PDF] |
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P. T. G. Elkington, J. E. Emerson, L. D. C. Lopez-Pascua, C. M. O'Kane, D. E. Horncastle, J. J. Boyle, and J. S. Friedland Mycobacterium tuberculosis Up-Regulates Matrix Metalloproteinase-1 Secretion from Human Airway Epithelial Cells via a p38 MAPK Switch J. Immunol., October 15, 2005; 175(8): 5333 - 5340. [Abstract] [Full Text] [PDF] |
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C. E. Girod and T. E. King Jr. COPD: A Dust-Induced Disease? Chest, October 1, 2005; 128(4): 3055 - 3064. [Abstract] [Full Text] [PDF] |
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E. L. Martin, L. A. McCaig, B. Z. Moyer, M. C. Pape, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L244 - L251. [Abstract] [Full Text] [PDF] |
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A. R. Pons, J. Sauleda, A. Noguera, J. Pons, B. Barcelo, A. Fuster, and A. G. N. Agusti Decreased macrophage release of TGF-{beta} and TIMP-1 in chronic obstructive pulmonary disease Eur. Respir. J., July 1, 2005; 26(1): 60 - 66. [Abstract] [Full Text] [PDF] |
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X. Lian, Y. Qin, S. A. Hossain, L. Yang, A. White, H. Xu, J. M. Shipley, T. Li, R. M. Senior, H. Du, et al. Overexpression of Stat3C in Pulmonary Epithelium Protects against Hyperoxic Lung Injury J. Immunol., June 1, 2005; 174(11): 7250 - 7256. [Abstract] [Full Text] [PDF] |
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M. B. Schabath, G. L. Delclos, M. M. Martynowicz, A. J. Greisinger, C. Lu, X. Wu, and M. R. Spitz Opposing Effects of Emphysema, Hay Fever, and Select Genetic Variants on Lung Cancer Risk Am. J. Epidemiol., March 1, 2005; 161(5): 412 - 422. [Abstract] [Full Text] [PDF] |
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K. Imai, B. A. Mercer, L. L. Schulman, J. R. Sonett, and J. M. D'Armiento Correlation of lung surface area to apoptosis and proliferation in human emphysema Eur. Respir. J., February 1, 2005; 25(2): 250 - 258. [Abstract] [Full Text] [PDF] |
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P. J. Barnes Mediators of Chronic Obstructive Pulmonary Disease Pharmacol. Rev., December 1, 2004; 56(4): 515 - 548. [Abstract] [Full Text] [PDF] |
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P. Bonniaud, M. Kolb, T. Galt, J. Robertson, C. Robbins, M. Stampfli, C. Lavery, P. J. Margetts, A. B. Roberts, and J. Gauldie Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF-{beta}-Mediated Pulmonary Fibrosis J. Immunol., August 1, 2004; 173(3): 2099 - 2108. [Abstract] [Full Text] [PDF] |
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J. Elias The Relationship Between Asthma and COPD: Lessons From Transgenic Mice Chest, August 1, 2004; 126(2_suppl_1): 111S - 116S. [Abstract] [Full Text] [PDF] |
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B. A. Mercer, N. Kolesnikova, J. Sonett, and J. D'Armiento Extracellular Regulated Kinase/Mitogen Activated Protein Kinase Is Up-regulated in Pulmonary Emphysema and Mediates Matrix Metalloproteinase-1 Induction by Cigarette Smoke J. Biol. Chem., April 23, 2004; 279(17): 17690 - 17696. [Abstract] [Full Text] [PDF] |
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S. S. Valenca, K. Da Hora, P. Castro, V. G. Moraes, L. Carvalho, and L. Cristo Vao De Moraes Sobrino Porto Emphysema and Metalloelastase Expression in Mouse Lung Induced by Cigarette Smoke Toxicol Pathol, April 1, 2004; 32(3): 351 - 356. [Abstract] [PDF] |
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A E Curley, D G Sweet, K J MacMahon, C M O'Connor, and H L Halliday Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2004; 89(1): F61 - F64. [Abstract] [Full Text] [PDF] |
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J. T. Mao, D. P. Tashkin, P. N. Belloni, I. Baileyhealy, F. Baratelli, and M. D. Roth All-trans Retinoic Acid Modulates the Balance of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Patients With Emphysema Chest, November 1, 2003; 124(5): 1724 - 1732. [Abstract] [Full Text] [PDF] |
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P.J. Barnes, S.D. Shapiro, and R.A. Pauwels Chronic obstructive pulmonary disease: molecular and cellularmechanisms Eur. Respir. J., October 1, 2003; 22(4): 672 - 688. [Abstract] [Full Text] [PDF] |
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L. G. Vazquez de Lara, T. M. Umstead, S. E. Davis, and D. S. Phelps Surfactant protein A increases matrix metalloproteinase-9 production by THP-1 cells Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L899 - L906. [Abstract] [Full Text] [PDF] |
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B. Suki, K. R. Lutchen, and E. P. Ingenito On the Progressive Nature of Emphysema: Roles of Proteases, Inflammation, and Mechanical Forces Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 516 - 521. [Full Text] [PDF] |
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T. Betsuyaku, M. Tanino, K. Nagai, Y. Nasuhara, M. Nishimura, and R. M. Senior Extracellular Matrix Metalloproteinase Inducer Is Increased in Smokers' Bronchoalveolar Lavage Fluid Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 222 - 227. [Abstract] [Full Text] [PDF] |
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M. Selman, J. Cisneros-Lira, M. Gaxiola, R. Ramirez, E. M. Kudlacz, P. G. Mitchell, and A. Pardo Matrix Metalloproteinases Inhibition Attenuates Tobacco Smoke-Induced Emphysema in Guinea Pigs Chest, May 1, 2003; 123(5): 1633 - 1641. [Abstract] [Full Text] [PDF] |
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A. Churg, R. D. Wang, H. Tai, X. Wang, C. Xie, J. Dai, S. D. Shapiro, and J. L. Wright Macrophage Metalloelastase Mediates Acute Cigarette Smoke-induced Inflammation via Tumor Necrosis Factor-{alpha} Release Am. J. Respir. Crit. Care Med., April 15, 2003; 167(8): 1083 - 1089. [Abstract] [Full Text] [PDF] |
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Y Hakoda, Y Ito, A Nagate, K Minemura, K Utsumi, M Aoshima, and K Ohyashiki Increased collagenase activity in macrophages from bronchial lavage as a diagnostic marker of non-small cell lung cancer Thorax, February 1, 2003; 58(2): 122 - 126. [Abstract] [Full Text] [PDF] |
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J. J. Atkinson and R. M. Senior Matrix Metalloproteinase-9 in Lung Remodeling Am. J. Respir. Cell Mol. Biol., January 1, 2003; 28(1): 12 - 24. [Abstract] [Full Text] [PDF] |
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M.T. Henry, K. McMahon, A.J. Mackarel, K. Prikk, T. Sorsa, P. Maisi, R. Sepper, M.X. FitzGerald, and C.M. O'Connor Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF Eur. Respir. J., November 1, 2002; 20(5): 1220 - 1227. [Abstract] [Full Text] [PDF] |
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J. L. Wright, S. G. Farmer, and A. Churg Synthetic Serine Elastase Inhibitor Reduces Cigarette Smoke-induced Emphysema in Guinea Pigs Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 954 - 960. [Abstract] [Full Text] |
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R. E. K. Russell, A. Thorley, S. V. Culpitt, S. Dodd, L. E. Donnelly, C. Demattos, M. Fitzgerald, and P. J. Barnes Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L867 - L873. [Abstract] [Full Text] [PDF] |
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A. Churg, K. Zay, S. Shay, C. Xie, S. D. Shapiro, R. Hendricks, and J. L Wright Acute Cigarette Smoke-Induced Connective Tissue Breakdown Requires both Neutrophils and Macrophage Metalloelastase in Mice Am. J. Respir. Cell Mol. Biol., September 1, 2002; 27(3): 368 - 374. [Abstract] [Full Text] [PDF] |
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J C Hogg and R M Senior Chronic obstructive pulmonary disease c 2: Pathology and biochemistry of emphysema Thorax, September 1, 2002; 57(9): 830 - 834. [Abstract] [Full Text] [PDF] |
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T. Kuraki, M. Ishibashi, M. Takayama, M. Shiraishi, and M. Yoshida A Novel Oral Neutrophil Elastase Inhibitor (ONO-6818) Inhibits Human Neutrophil Elastase-induced Emphysema in Rats Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 496 - 500. [Abstract] [Full Text] [PDF] |
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F Blasi, S Damato, R Cosentini, P Tarsia, R Raccanelli, S Centanni, and L Allegra Chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatment Thorax, August 1, 2002; 57(8): 672 - 676. [Abstract] [Full Text] [PDF] |
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R. E. K. Russell, S. V. Culpitt, C. DeMatos, L. Donnelly, M. Smith, J. Wiggins, and P. J. Barnes Release and Activity of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Cell Mol. Biol., May 1, 2002; 26(5): 602 - 609. [Abstract] [Full Text] [PDF] |
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K. H. Choi, H. B. Lee, M. Y. Jeong, Y. K. Rhee, M. J. Chung, Y. G. Kwak, and Y. C. Lee The Role of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Cryptogenic Organizing Pneumonia* Chest, May 1, 2002; 121(5): 1478 - 1485. [Abstract] [Full Text] [PDF] |
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T. D. Tetley Macrophages and the Pathogenesis of COPD* Chest, May 1, 2002; 121(5_suppl): 156S - 159S. [Abstract] [Full Text] [PDF] |
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W. I. de Boer Cytokines and Therapy in COPD* : A Promising Combination? Chest, May 1, 2002; 121(5_suppl): 209S - 218S. [Abstract] |