BM Hybertson, EK Jepson, OJ Cho, JH Clarke, YM Lee and JE Repine
The Webb-Waring Institute for Biomedical Research and the Department of Medicine at the University of Colorado Health Sciences Center, Denver 80262, USA.

Interleukin-1 (IL-1) is increased in lung lavages obtained from patients with acute respiratory distress syndrome, and administering IL- 1 intratracheally to rats causes an acute, neutrophil-dependent, oxidative lung leak. We found that rats given IL-1 intratracheally had increased lung lavage fluid tumor necrosis factor (TNF) levels, and that rats treated with TNF binding protein (TNFbp) intravenously did not develop the increased lung leak that occurs after administration of IL-1 intratracheally. In contrast, rats given IL-1 intratracheally and TNFbp intravenously had the same elevations in lung lavage neutrophil accumulation and lung lavage cytokine-induced neutrophil chemoattractant levels as rats given IL-1 intratracheally. Our results show that TNFbp decreases neutrophil-mediated lung leak, but not lung neutrophil accumulation, after administration of IL-1 intratracheally in rats.

This article has been cited by other articles:

				J.-H. Lee, L. Del Sorbo, A. A. Khine, J. de Azavedo, D. E. Low, D. Bell, S. Uhlig, A. S. Slutsky, and H. Zhang Modulation of Bacterial Growth by Tumor Necrosis Factor-{alpha} In Vitro and In Vivo Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1462 - 1470. [Abstract] [Full Text] [PDF]

				A. H. van Houwelingen, M. Kool, S. C. A. de Jager, F. A. M. Redegeld, D. van Heuven-Nolsen, A. D. Kraneveld, and F. P. Nijkamp Mast Cell-Derived TNF-{alpha} Primes Sensory Nerve Endings in a Pulmonary Hypersensitivity Reaction J. Immunol., May 15, 2002; 168(10): 5297 - 5302. [Abstract] [Full Text] [PDF]

				E. Alcamo, J. P. Mizgerd, B. H. Horwitz, R. Bronson, A. A. Beg, M. Scott, C. M. Doerschuk, R. O. Hynes, and D. Baltimore Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-{kappa}B in Leukocyte Recruitment J. Immunol., August 1, 2001; 167(3): 1592 - 1600. [Abstract] [Full Text] [PDF]

				J. G. Wagner and R. A. Roth Neutrophil Migration Mechanisms, with an Emphasis on the Pulmonary Vasculature Pharmacol. Rev., September 1, 2000; 52(3): 349 - 374. [Abstract] [Full Text] [PDF]

				Y. M. Lee, B. M. Hybertson, H. G. Cho, L. S. Terada, O. Cho, A. J. Repine, and J. E. Repine Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L75 - L80. [Abstract] [Full Text] [PDF]

				J. Fan, A. Kapus, Y. H. Li, S. Rizoli, J. C. Marshall, and O. D. Rotstein Priming for Enhanced Alveolar Fibrin Deposition after Hemorrhagic Shock . Role of Tumor Necrosis Factor Am. J. Respir. Cell Mol. Biol., April 1, 2000; 22(4): 412 - 421. [Abstract] [Full Text]

				J. P. Mizgerd, J. J. Peschon, and C. M. Doerschuk Roles of Tumor Necrosis Factor Receptor Signaling during Murine Escherichia coli Pneumonia Am. J. Respir. Cell Mol. Biol., January 1, 2000; 22(1): 85 - 91. [Abstract] [Full Text]

				J. G. Wagner, K. E. Driscoll, and R. A. Roth Inhibition of Pulmonary Neutrophil Trafficking during Endotoxemia Is Dependent on the Stimulus for Migration Am. J. Respir. Cell Mol. Biol., April 1, 1999; 20(4): 769 - 776. [Abstract] [Full Text]

				P. M. HASSOUN, F.-S. YU, C. G. COTE, J. J. ZULUETA, R. SAWHNEY, K. A. SKINNER, H. B. SKINNER, D. A. PARKS, and J. J. LANZILLO Upregulation of Xanthine Oxidase by Lipopolysaccharide, Interleukin-1, and Hypoxia . Role in Acute Lung Injury Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 299 - 305. [Abstract] [Full Text] [PDF]