Am. J. Respir. Crit. Care Med., Vol 155, No. 2, Feb 1997, 743-746.
Combined therapy with inhaled nitric oxide and intravenous prostacyclin in an infant with alveolar-capillary dysplasia
TA Parker, DD Ivy, JP Kinsella, F Torielli, SZ Ruyle, EH Thilo and SH Abman
Department of Pediatrics, University of Colorado School of Medicine, The Children's Hospital, Denver, USA.
Severe persistent pulmonary hypertension of the newborn (PPHN) remains a
significant cause of neonatal morbidity and mortality with limited
effective treatment options. We present the first case of a neonate with
PPHN treated concurrently with inhaled nitric oxide (iNO) and intravenous
prostacyclin (PGI2). He ultimately was diagnosed with alveolar-capillary
dysplasia, a rare and fatal cause of pulmonary hypertension. However, his
partial response to treatment demonstrates a possible role for combined
therapy with iNO and PGI2 in infants with severe PPHN.
