PE Silkoff, PA McClean, AS Slutsky, HG Furlott, E Hoffstein, S Wakita, KR Chapman, JP Szalai and N Zamel
Department of Medicine, the University of Toronto, Ontario, Canada.

Exhaled nitric oxide (NO) may aid in monitoring pulmonary disease. The single-breath NO profile (subjects with nose clip) was described as a NO peak followed by a plateau (NO(PLAT)). Published exhaled NO values vary greatly, possibly due to contamination with nasal NO and differing respiratory maneuvers. We developed a technique to measure pulmonary NO, without nasal NO, by having the subject maintain a positive expiratory pressure (ensuring vellum closure), and we examined the variation in NO(PLAT) over a range of expiratory flows (4.2 to 1,550 ml/s). NO(PLAT) values rose almost 35-fold (3.2 +/- 1.4 ppb to 110.5 +/- 54.8 ppb) with decreasing flow, described by NO(PLAT) = 208.6795 x (flow rate)(-0.5995). However, NO excretion showed an almost 11-fold rise as flow increased. In summary, we present a simple technique for measuring exhaled NO without contamination by nasal NO. There is a marked flow dependence of exhaled NO concentration and excretion. Exhaled pulmonary NO is best measured at very low flow rates to amplify the signal and must be related to the expiratory flow employed.

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				J. F. HUNT, K. FANG, R. MALIK, A. SNYDER, N. MALHOTRA, T. A. E. PLATTS-MILLS, and B. GASTON Endogenous Airway Acidification . Implications for Asthma Pathophysiology Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 694 - 699. [Abstract] [Full Text] [PDF]

				M. SCOLLO, S. ZANCONATO, R. ONGARO, C. ZARAMELLA, F. ZACCHELLO, and E. BARALDI Exhaled Nitric Oxide and Exercise-Induced Bronchoconstriction in Asthmatic Children Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 1047 - 1050. [Abstract] [Full Text] [PDF]

				N. D. Ferguson and J. T. Granton Inhaled nitric oxide for hypoxemic respiratory failure: Passing bad gas? Can. Med. Assoc. J., January 1, 2000; 162(1): 85 - 86. [Full Text] [PDF]

				E. GABBAY, E. HAYDN WALTERS, B. ORSIDA, H. WHITFORD, C. WARD, T. C. KOTSIMBOS, G. I. SNELL, and T. J. WILLIAMS In Stable Lung Transplant Recipients, Exhaled Nitric Oxide Levels Positively Correlate with Airway Neutrophilia and Bronchial Epithelial iNOS Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 2093 - 2099. [Abstract] [Full Text]

				B. D. Johnson, K. C. Beck, R. J. Zeballos, and I. M. Weisman Advances in Pulmonary Laboratory Testing Chest, November 1, 1999; 116(5): 1377 - 1387. [Abstract] [Full Text] [PDF]

				A. P. Pietropaoli, I. B. Perillo, A. Torres, P. T. Perkins, L. M. Frasier, M. J. Utell, M. W. Frampton, and R. W. Hyde Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans J Appl Physiol, October 1, 1999; 87(4): 1532 - 1542. [Abstract] [Full Text] [PDF]

				J O N Lundberg and E Weitzberg Nasal nitric oxide in man Thorax, October 1, 1999; 54(10): 947 - 952. [Full Text]

				P. E. Silkoff, A. Stevens, J. Pak, B. Bucher-Bartelson, and R. J. Martin A Method for the Standardized Offline Collection of Exhaled Nitric Oxide Chest, September 1, 1999; 116(3): 754 - 759. [Abstract] [Full Text] [PDF]

				J. M. CHATKIN, K. ANSARIN, P. E. SILKOFF, P. MCCLEAN, C. GUTIERREZ, N. ZAMEL, and K. R. CHAPMAN Exhaled Nitric Oxide as a Noninvasive Assessment of Chronic Cough Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1810 - 1813. [Abstract] [Full Text]

				M. CHAN-YEUNG, H. OBATA, M. DITTRICK, H. CHAN, and R. ABBOUD Airway Inflammation, Exhaled Nitric Oxide, and Severity of Asthma in Patients with Western Red Cedar Asthma Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1434 - 1438. [Abstract] [Full Text] [PDF]

				C. M. ST. CROIX, T. J. WETTER, D. F. PEGELOW, K. C. MEYER, and J. A. DEMPSEY Assessment of Nitric Oxide Formation During Exercise Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): 1125 - 1133. [Abstract] [Full Text] [PDF]

				S. E. CRATER, E. J. PETERS, M. L. MARTIN, A. W. MURPHY, and T. A. E. PLATTS-MILLS Expired Nitric Oxide and Airway Obstruction in Asthma Patients with an Acute Exacerbation Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 806 - 811. [Abstract] [Full Text]

				C. M. SALOME, A. M. ROBERTS, N. J. BROWN, J. DERMAND, G. B. MARKS, and A. J. WOOLCOCK Exhaled Nitric Oxide Measurements in a Population Sample of Young Adults Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 911 - 916. [Abstract] [Full Text]