Am. J. Respir. Crit. Care Med., Vol 154, No. 5, 11 1996, 1351-1356.
The effect of atrial natriuretic peptide on pulmonary acid injury in a pig model
M Tanabe, M Ueda, M Endo and M Kitajima
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
The effect of exogenous atrial natriuretic peptide (ANP) on pulmonary
injury induced by aspiration of hydrochloric acid (0.1 N HCl, 2.0 ml/kg)
was examined in anesthetized pigs ventilated with 100% oxygen.
Group-specific diuretic treatment was used 60 min after aspiration and
followed for a further 120 min. No diuretics were used for Group 1, 0.1
microg/kg/min of ANP was infused intravenously for 60 min in Group 2, and
0.05 mg/kg of furosemide was injected (intravenous bolus) in Group 3. Total
urine volume after diuretic treatment did not differ significantly between
Groups 2 and 3. However, the increase in PaO2 (to 386.3 +/- 67.5 mm Hg)
after infusion of ANP was significantly higher than the increase in PaO2
(to 275.9 +/- 63.3 mm Hg) after furosemide treatment, and in the no
treatment control (to 171.1 +/- 31.5 mm Hg). Pulmonary hypertension induced
by acid aspiration was significantly reduced (p < 0.01 versus Groups 1
and 3) during ANP infusion. ANP has a beneficial effect on acute lung
injury, possibly through its diuretic and/or pulmonary vasodilating action.
