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Am. J. Respir. Crit. Care Med., Vol 152, No. 6, 12 1995, 2170-2172.

Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose

SM Salerno, JS Strong, BJ Roth and V Sakata
Department of Medicine, Madigan Army Medical Center, Tacoma, Washington 98431-5000, USA.

Drug-induced eosinophilic lung disease commonly presents as a simple pulmonary eosinophilia-like syndrome consisting of transient pulmonary infiltrates, peripheral eosinophilia, and mild pulmonary symptoms that disappear promptly upon withdrawal of the offending medication. However, a more fulminant presentation most resembling acute eosinophilic pneumonia has been recently described. We present a patient with BAL-confirmed eosinophilic pneumonia (EP) and respiratory failure after a trazodone overdose. This is the first case of EP associated with trazodone and only the third drug-mediated EP reported to precipitate respiratory failure.


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