WW Busse, RL Coffman, EW Gelfand, AB Kay and LJ Rosenwasser

The role of T cells in human allergic inflammation is just beginning to be understood. However, the data presented indicate how the T cell may be a pivotal cell to direct features of allergic inflammation in asthma, how the T cell may be able to transfer hyperresponsiveness, which is a feature of bronchial asthma, what some of the genetic factors are that may determine this process, and how an important precipitant of asthma, viral respiratory infections, may participate in this process. Its cells are isolated from patients with asthma and studied for their ability to generate proinflammatory failure. An expanded understanding of the chronic, persistent nature of asthma will become apparent.

This article has been cited by other articles:

				T. Koya, N. Miyahara, K. Takeda, S. Matsubara, H. Matsuda, C. Swasey, A. Balhorn, A. Dakhama, and E. W. Gelfand CD8+ T Cell-Mediated Airway Hyperresponsiveness and Inflammation Is Dependent on CD4+IL-4+ T Cells J. Immunol., September 1, 2007; 179(5): 2787 - 2796. [Abstract] [Full Text] [PDF]

				M. C. Rose and J. A. Voynow Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease Physiol Rev, January 1, 2006; 86(1): 245 - 278. [Abstract] [Full Text] [PDF]

				Y. Chiba, T. Kusakabe, and S. Kimura Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9 Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1193 - L1198. [Abstract] [Full Text] [PDF]

				A H Mansur, D T Bishop, S T Holgate, A F Markham, and J F J Morrison Linkage/association study of a locus modulating total serum IgE on chromosome 14q13-24 in families with asthma Thorax, October 1, 2004; 59(10): 876 - 882. [Abstract] [Full Text] [PDF]

				V. De Rose, P. Cappello, V. Sorbello, B. Ceccarini, F. Gani, M. Bosticardo, S. Fassio, and F. Novelli IFN-{gamma} inhibits the proliferation of allergen-activated T lymphocytes from atopic, asthmatic patients by inducing Fas/FasL-mediated apoptosis J. Leukoc. Biol., August 1, 2004; 76(2): 423 - 432. [Abstract] [Full Text] [PDF]

				L. L. Chen, I. B. Tager, D. B. Peden, D. L. Christian, R. E. Ferrando, B. S. Welch, and J. R. Balmes Effect of Ozone Exposure on Airway Responses to Inhaled Allergen in Asthmatic Subjects Chest, June 1, 2004; 125(6): 2328 - 2335. [Abstract] [Full Text] [PDF]

				N. Miyahara, K. Takeda, T. Kodama, A. Joetham, C. Taube, J.-W. Park, S. Miyahara, A. Balhorn, A. Dakhama, and E. W. Gelfand Contribution of Antigen-Primed CD8+ T Cells to the Development of Airway Hyperresponsiveness and Inflammation Is Associated with IL-13 J. Immunol., February 15, 2004; 172(4): 2549 - 2558. [Abstract] [Full Text] [PDF]

				Y.-S. Hahn, C. Taube, N. Jin, K. Takeda, J.-W. Park, J. M. Wands, M. K. Aydintug, C. L. Roark, M. Lahn, R. L. O'Brien, et al. V{gamma}4+ {gamma}{delta} T Cells Regulate Airway Hyperreactivity to Methacholine in Ovalbumin-Sensitized and Challenged Mice J. Immunol., September 15, 2003; 171(6): 3170 - 3178. [Abstract] [Full Text] [PDF]

				C. Taube, C. Duez, Z.-H. Cui, K. Takeda, Y.-H. Rha, J.-W. Park, A. Balhorn, D. D. Donaldson, A. Dakhama, and E. W. Gelfand The Role of IL-13 in Established Allergic Airway Disease J. Immunol., December 1, 2002; 169(11): 6482 - 6489. [Abstract] [Full Text] [PDF]

				P. Pala, R. Bjarnason, F. Sigurbergsson, C. Metcalfe, N. Sigurs, and P.J.M. Openshaw Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy Eur. Respir. J., August 1, 2002; 20(2): 376 - 382. [Abstract] [Full Text] [PDF]

				G. Cheng, M. Arima, K. Honda, H. Hirata, F. Eda, N. Yoshida, F. Fukushima, Y. Ishii, and T. Fukuda Anti-Interleukin-9 Antibody Treatment Inhibits Airway Inflammation and Hyperreactivity in Mouse Asthma Model Am. J. Respir. Crit. Care Med., August 1, 2002; 166(3): 409 - 416. [Abstract] [Full Text] [PDF]

				T. A. E. PLATTS-MILLS The Role of Immunoglobulin E in Allergy and Asthma Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): S1 - 5. [Abstract] [Full Text] [PDF]

				E. S. SCHULMAN Development of a Monoclonal Anti-Immunoglobulin E Antibody (Omalizumab) for the Treatment of Allergic Respiratory Disorders Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): S6 - 11. [Abstract] [Full Text] [PDF]

				J. I. Barzilay, L. Abraham, S. R. Heckbert, M. Cushman, L. H. Kuller, H. E. Resnick, and R. P. Tracy The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly: The Cardiovascular Health Study Diabetes, October 1, 2001; 50(10): 2384 - 2389. [Abstract] [Full Text]

				J. G. Ford, D. Rennick, D. D. Donaldson, R. Venkayya, C. McArthur, E. Hansell, V. P. Kurup, M. Warnock, and G. Grunig IL-13 and IFN-{gamma}: Interactions in Lung Inflammation J. Immunol., August 1, 2001; 167(3): 1769 - 1777. [Abstract] [Full Text] [PDF]

				J. BOUSQUET, P. K. JEFFERY, W. W. BUSSE, M. JOHNSON, and A. M. VIGNOLA Asthma . From Bronchoconstriction to Airways Inflammation and Remodeling Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1720 - 1745. [Full Text]

				M. Ikegami, J. A. Whitsett, Z. C. Chroneos, G. F. Ross, J. A. Reed, C. J. Bachurski, and A. H. Jobe IL-4 increases surfactant and regulates metabolism in vivo Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L75 - L80. [Abstract] [Full Text] [PDF]

				M. MATHUR, K. HERRMANN, X. LI, Y. QIN, J. WEINSTOCK, D. ELLIOTT, J. MONAHAN, and P. PADRID TRFK-5 Reverses Established Airway Eosinophilia But Not Established Hyperresponsiveness in a Murine Model of Chronic Asthma Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 580 - 587. [Abstract] [Full Text]

				U.-A. Temann, G. P. Geba, J. A. Rankin, and R. A. Flavell Expression of Interleukin 9 in the Lungs of  Transgenic Mice Causes Airway Inflammation, Mast Cell Hyperplasia, and Bronchial Hyperresponsiveness J. Exp. Med., October 5, 1998; 188(7): 1307 - 1320. [Abstract] [Full Text] [PDF]

				A. L. LAMBERT, D. W. WINSETT, D. L. COSTA, M. K. SELGRADE, and M. IAN GILMOUR Transfer of Allergic Airway Responses with Serum and Lymphocytes from Rats Sensitized to Dust Mite Am. J. Respir. Crit. Care Med., June 1, 1998; 157(6): 1991 - 1999. [Abstract] [Full Text] [PDF]

				M. Silverman, N. Wilson;, and N. SPEIGHT Asthma---time for a change of name? • Commentary Arch. Dis. Child., July 1, 1997; 77(1): 62 - 65. [Full Text]