Am. J. Respir. Crit. Care Med., Vol 152, No. 1, 07 1995, 374-376.
Mycobacterium tuberculosis in lung transplant recipients
RA Miller, LA Lanza, JN Kline and LJ Geist
Department of Medicine, Veterans Affairs Administration Medical Center, Iowa City, Iowa, USA.
The diagnosis and treatment of Mycobacterium tuberculosis, although
difficult in normal hosts, are even more complex in transplant recipients.
As a result of the use of immunosuppressive agents, transplant recipients
are not only predisposed to primary tuberculous infections, but they are
also uniquely at risk for reactivation of latent infection acquired prior
to transplantation or transmitted via the donor organ. The diagnosis of
pulmonary tuberculosis can be even more elusive in the setting of lung
transplantation where other pulmonary complications can make diagnosis
difficult. Here we report a case of a patient who died of disseminated M.
tuberculosis 12 wk after lung transplantation, and we review tuberculous
infections in lung transplant recipients.