CN Sessler, AC Windsor, M Schwartz, L Watson, BJ Fisher, HJ Sugerman and AA Fowler 3rd
Department of Internal Medicine, Medical College of Virginia-Virginia Commonwealth University, Richmond, USA.

Adhesion molecules play a critical role in the interaction of circulating neutrophils with vascular endothelium during inflammation. Increased quantities of soluble, circulating intercellular adhesion molecule-1 (cICAM-1) are present in various inflammatory conditions. The purpose of this investigation was to measure cICAM-1 levels in septic adults, as well as to examine the relationship between this potential marker of endothelial-cell activation and the consequences of sepsis (i.e., multiple organ failure and death). Using a sandwich-type enzyme-linked immunosorbent assay (ELISA), we measured cICAM-1 in blood samples obtained within 12 h of admission to an intensive care unit (ICU) for sepsis and other conditions. We found cICAM-1 levels to be increased in 25 septic patients (1,259 +/- 159 ng/ml, mean +/- SEM) as compared with 12 healthy volunteers (355 +/- 41 ng/ml, p < 0.0001) and four ICU patients without systemic inflammatory response syndrome (SIRS) (585 +/- 76 ng/ml, p < 0.001). Twenty-five patients with SIRS but no evidence of causative infection also had elevated levels of cICAM-1 (937 +/- 144 ng/ml, p = 0.12 versus sepsis). Serial measurements over the first week of sepsis demonstrated persistent elevation in most patients. Day 1 cICAM-1 levels were higher (p = 0.017, ANOVA) in 16 patients with septic shock than in seven with severe sepsis and two with sepsis but without hypotension or hypoperfusion. There was a positive correlation (r = 0.50, p = 0.009) between Day-1 cICAM-1 measurements and severity of shock as determined by the presence of hypotension and vasopressor use.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				T. Nishiyama Antithrombin can modulate coagulation, cytokine production, and expression of adhesion molecules in abdominal aortic aneurysm repair surgery. Anesth. Analg., April 1, 2006; 102(4): 1007 - 1011. [Abstract] [Full Text] [PDF]

				I. J. Laudes, R.-F. Guo, N. C. Riedemann, C. Speyer, R. Craig, J. V. Sarma, and P. A. Ward Disturbed Homeostasis of Lung Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 During Sepsis Am. J. Pathol., April 1, 2004; 164(4): 1435 - 1445. [Abstract] [Full Text] [PDF]

				K. Lang, S. Suttner, J. Boldt, B. Kumle, and D. Nagel Volume replacement with HES 130/0.4 may reduce the inflammatory response in patients undergoing major abdominal surgery: [Le remplissage vasculaire avec de l'HEA 130/0,4 peut reduire la reaction inflammatoire chez des patients en chirurgie abdominale majeure] Can J Anesth, December 1, 2003; 50(10): 1009 - 1016. [Abstract] [Full Text] [PDF]

				M. Kinoshita, S. Ono, and H. Mochizuki Neutrophil-Related Inflammatory Mediators in Septic Acute Respiratory Distress Syndrome J Intensive Care Med, November 1, 2002; 17(6): 308 - 316. [Abstract] [PDF]

				R. E. Weiner, D. E. Sasso, M. A. Gionfriddo, R. S. Thrall, S. Syrbu, H. M. Smilowitz, and J. Vento Early Detection of Oleic Acid-Induced Lung Injury in Rats Using 111In-Labeled Anti-Rat Intercellular Adhesion Molecule-1 J. Nucl. Med., July 1, 2001; 42(7): 1109 - 1115. [Abstract] [Full Text] [PDF]

				H. Kern, R. Wittich, U. Rohr, W. J. Kox, and C. D. Spies Increased Endothelial Injury in Septic Patients With Coronary Artery Disease Chest, March 1, 2001; 119(3): 874 - 883. [Abstract] [Full Text] [PDF]

				M. GARDINALI, E. BORRELLI, O. CHIARA, C. LUNDBERG, P. PADALINO, L. CONCIATO, C. CAFARO, S. LAZZI, P. LUZI, P. P. GIOMARELLI, et al. Inhibition of CD11-CD18 Complex Prevents Acute Lung Injury and Reduces Mortality after Peritonitis in Rabbits Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 1022 - 1029. [Abstract] [Full Text] [PDF]

				B. Chernow Variables Affecting Outcome in Critically Ill Patients Chest, May 1, 1999; 115(suppl_2): 71S - 76S. [Abstract] [Full Text] [PDF]

				B. JILMA, A. BLANN, T. PERNERSTORFER, P. STOHLAWETZ, H.-G. EICHLER, B. VONDROVEC, J. AMIRAL, V. RICHTER, and O. F. WAGNER Regulation of Adhesion Molecules during Human Endotoxemia . No Acute Effects of Aspirin Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 857 - 863. [Abstract] [Full Text]

				A. P. Wheeler and G. R. Bernard Treating Patients with Severe Sepsis N. Engl. J. Med., January 21, 1999; 340(3): 207 - 214. [Full Text] [PDF]

				M. Weiss, L. L. Moldawer, and E. M. Schneider Granulocyte Colony-Stimulating Factor to Prevent the Progression of Systemic Nonresponsiveness in Systemic Inflammatory Response Syndrome and Sepsis Blood, January 15, 1999; 93(2): 425 - 439. [Full Text] [PDF]

				P B Baines, O Marzouk, A P J Thomson, J A Sills, F A I Riordan, and C A Hart Endothelial cell adhesion molecules in meningococcal disease Arch. Dis. Child., January 1, 1999; 80(1): 74 - 76. [Abstract] [Full Text]

				A. H. M. FROON, M. J. M. BONTEN, C. A. GAILLARD, J. W. M. GREVE, M. A. DENTENER, P. W. de LEEUW, M. DRENT, E. E. STOBBERINGH, and W. A. BUURMAN Prediction of Clinical Severity and Outcome of Ventilator-associated Pneumonia . Comparison of Simplified Acute Physiology Score with Systemic Inflammatory Mediators Am. J. Respir. Crit. Care Med., October 1, 1998; 158(4): 1026 - 1031. [Abstract] [Full Text] [PDF]

				V. DE ROSE, A. OLIVA, B. MESSORE, B. GROSSO, C. MOLLAR, and E. POZZI Circulating Adhesion Molecules in Cystic Fibrosis Am. J. Respir. Crit. Care Med., April 1, 1998; 157(4): 1234 - 1239. [Abstract] [Full Text] [PDF]

				J. S. Steingrub Novel Insights Into the Pathogenesis and Therapy of Circulatory Shock Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 1998; 2(1): 31 - 45. [Abstract] [PDF]

				S. KAYAL, J.-P. JAIS, N. AGUINI, J. CHAUDIERE, and J. LABROUSSE Elevated Circulating E-Selectin, Intercellular Adhesion Molecule 1, and von Willebrand Factor in Patients with Severe Infection Am. J. Respir. Crit. Care Med., March 1, 1998; 157(3): 776 - 784. [Abstract] [Full Text] [PDF]

				Y. Ohashi, Y. Nakai, A. Tanaka, Y. Kakinoki, Y. Ohno, T. Masamoto, H. Sakamoto, A. Kato, Y. Washio, K. Yamada, et al. Clinical Role of Soluble Adhesion Molecules During Immunotherapy for Perennial Allergic Rhinitis Arch Otolaryngol Head Neck Surg, January 1, 1998; 124(1): 41 - 45. [Abstract] [Full Text] [PDF]

				C. J. CUMMINGS, C. N. SESSLER, L. D. BEALL, B. J. FISHER, A. M. BEST, and A. A. FOWLER III Soluble E-Selectin Levels in Sepsis and Critical Illness . Correlation with Infection and Hemodynamic Dysfunction Am. J. Respir. Crit. Care Med., July 1, 1997; 156(2): 431 - 437. [Abstract] [Full Text]