CA Pope 3rd, MJ Thun, MM Namboodiri, DW Dockery, JS Evans, FE Speizer and CW Heath Jr
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.

Time-series, cross-sectional, and prospective cohort studies have observed associations between mortality and particulate air pollution but have been limited by ecologic design or small number of subjects or study areas. The present study evaluates effects of particulate air pollution on mortality using data from a large cohort drawn from many study areas. We linked ambient air pollution data from 151 U.S. metropolitan areas in 1980 with individual risk factor on 552,138 adults who resided in these areas when enrolled in a prospective study in 1982. Deaths were ascertained through December, 1989. Exposure to sulfate and fine particulate air pollution, which is primarily from fossil fuel combustion, was estimated from national data bases. The relationships of air pollution to all-cause, lung cancer, and cardiopulmonary mortality was examined using multivariate analysis which controlled for smoking, education, and other risk factors. Although small compared with cigarette smoking, an association between mortality and particulate air pollution was observed. Adjusted relative risk ratios (and 95% confidence intervals) of all-cause mortality for the most polluted areas compared with the least polluted equaled 1.15 (1.09 to 1.22) and 1.17 (1.09 to 1.26) when using sulfate and fine particulate measures respectively. Particulate air pollution was associated with cardiopulmonary and lung cancer mortality but not with mortality due to other causes. Increased mortality is associated with sulfate and fine particulate air pollution at levels commonly found in U.S. cities. The increase in risk is not attributable to tobacco smoking, although other unmeasured correlates of pollution cannot be excluded with certainty.

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				T. P. J. Hofer, E. Bitterle, I. Beck-Speier, K. L. Maier, M. Frankenberger, J. Heyder, and L. Ziegler-Heitbrock Diesel exhaust particles increase LPS-stimulated COX-2 expression and PGE2 production in human monocytes J. Leukoc. Biol., May 1, 2004; 75(5): 856 - 864. [Abstract] [Full Text] [PDF]

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				K. Katsouyanni Ambient air pollution and health Br. Med. Bull., December 1, 2003; 68(1): 143 - 156. [Abstract] [Full Text] [PDF]

				H C Routledge, J G Ayres, and J N Townend Why cardiologists should be interested in air pollution Heart, December 1, 2003; 89(12): 1383 - 1388. [Abstract] [Full Text] [PDF]

				P Nafstad, L L Haheim, B Oftedal, F Gram, I Holme, I Hjermann, and P Leren Lung cancer and air pollution: a 27 year follow up of 16 209 Norwegian men Thorax, December 1, 2003; 58(12): 1071 - 1076. [Abstract] [Full Text] [PDF]

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				L Filleul, I Baldi, J-F Dartigues, and J-F Tessier Risk factors among elderly for short term deaths related to high levels of air pollution Occup. Environ. Med., September 1, 2003; 60(9): 684 - 688. [Abstract] [Full Text] [PDF]

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				H. Takizawa, S. Abe, H. Okazaki, T. Kohyama, I. Sugawara, Y. Saito, T. Ohtoshi, S. Kawasaki, M. Desaki, K. Nakahara, et al. Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-kappa B-dependent pathway Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L1055 - L1062. [Abstract] [Full Text] [PDF]

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				B G Miller and J F Hurley Life table methods for quantitative impact assessments in chronic mortality J Epidemiol Community Health, March 1, 2003; 57(3): 200 - 206. [Abstract] [Full Text] [PDF]

				C. G. Tankersley, R. Irizarry, S. E. Flanders, R. Rabold, and R. Frank Unstable heart rate and temperature regulation predict mortality in AKR/J mice Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R742 - R750. [Abstract] [Full Text] [PDF]

				H.-M. Yang, L. Butterworth, A. E. Munson, and B. J. Meade Respiratory Exposure to Diesel Exhaust Particles Decreases the Spleen IgM Response to a T Cell-Dependent Antigen in Female B6C3F1 Mice Toxicol. Sci., February 1, 2003; 71(2): 207 - 216. [Abstract] [Full Text] [PDF]

				E.-H. Ha, J.-T. Lee, H. Kim, Y.-C. Hong, B.-E. Lee, H.-S. Park, and D. C. Christiani Infant Susceptibility of Mortality to Air Pollution in Seoul, South Korea Pediatrics, February 1, 2003; 111(2): 284 - 290. [Abstract] [Full Text] [PDF]

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				J. Just, C. Segala, F. Sahraoui, G. Priol, A. Grimfeld, and F. Neukirch Short-term health effects of particulate and photochemical air pollution in asthmatic children Eur. Respir. J., October 1, 2002; 20(4): 899 - 906. [Abstract] [Full Text] [PDF]

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				G. D'Amato, G. Liccardi, M. D'Amato, and M. Cazzola Outdoor air pollution, climatic changes and allergic bronchial asthma Eur. Respir. J., September 1, 2002; 20(3): 763 - 776. [Abstract] [Full Text] [PDF]

				V. Shilton, P. Giess, D. Mitchell, and C. Williams The Relationships between Indoor and Outdoor Respirable Particulate Matter: Meteorology, Chemistry and Personal Exposure Indoor and Built Environment, September 1, 2002; 11(5): 266 - 274. [Abstract] [PDF]

				F. Dominici, A. McDermott, S. L. Zeger, and J. M. Samet On the Use of Generalized Additive Models in Time-Series Studies of Air Pollution and Health Am. J. Epidemiol., August 1, 2002; 156(3): 193 - 203. [Abstract] [Full Text] [PDF]

				N. Kunzli The public health relevance of air pollution abatement Eur. Respir. J., July 1, 2002; 20(1): 198 - 209. [Abstract] [Full Text] [PDF]

				P. H. N. Saldiva, R. W. Clarke, B. A. Coull, R. C. Stearns, J. Lawrence, G. G. K. Murthy, E. Diaz, P. Koutrakis, H. Suh, A. Tsuda, et al. Lung Inflammation Induced by Concentrated Ambient Air Particles Is Related to Particle Composition Am. J. Respir. Crit. Care Med., June 15, 2002; 165(12): 1610 - 1617. [Abstract] [Full Text] [PDF]

				F. Horak Jr, M. Studnicka, C. Gartner, J.D. Spengler, E. Tauber, R. Urbanek, A. Veiter, and T. Frischer Particulate matter and lung function growth in children: a 3-yr follow-up study in Austrian schoolchildren Eur. Respir. J., May 1, 2002; 19(5): 838 - 845. [Abstract] [Full Text] [PDF]

				A. Abelsohn, D. Stieb, M. D. Sanborn, and E. Weir Identifying and managing adverse environmental health effects: 2. Outdoor air pollution Can. Med. Assoc. J., April 1, 2002; 166(9): 1161 - 1167. [Abstract] [Full Text] [PDF]

				S. A. Glantz Air pollution as a cause of heart disease: Time for action J. Am. Coll. Cardiol., March 20, 2002; 39(6): 943 - 945. [Full Text] [PDF]

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				J G Ayres Chronic effects of air pollution Occup. Environ. Med., March 1, 2002; 59(3): 147 - 148. [Full Text] [PDF]

				F W Lipfert and S C Morris Temporal and spatial relations between age specific mortality and ambient air quality in the United States: regression results for counties, 1960-97 Occup. Environ. Med., March 1, 2002; 59(3): 156 - 174. [Abstract] [Full Text] [PDF]

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