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Am. J. Respir. Crit. Care Med., Vol 150, No. 4, Oct 1994, 988-994.

Antigen-specific stimulation of histamine releasing factors in diisocyanate-induced occupational asthma

ZL Herd and DI Bernstein
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio.

Diisocyanate-induced asthma differs from occupational asthma (OA) caused by protein allergens in that specific IgE antibody responses are rarely identified. To investigate the immunopathogenesis of diisocyanate asthma, diisocyanate-exposed workers were evaluated for in vitro production of antigen-specific mononuclear cell-derived histamine releasing factor (HRF). The mean HRF response to diisocyanate-HSA antigens was significantly greater in patients with OA than in diisocyanate-exposed asymptomatic subjects (p < 0.05). No association was found between HRF and diisocyanate-specific antibodies. Analysis of HRF production by subpopulations of peripheral blood mononuclear cells (PBMC) showed that lymphocytes and adherent cells were major sources of both spontaneous and antigen-stimulated HRF. The results suggest that antigen-specific HRF produced by PBMCs are an important biomarker for diisocyanate-induced asthma. This is the first report of hapten- specific stimulation of PBMCs resulting in HRF production.


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Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1994 American Thoracic Society