Am. J. Respir. Crit. Care Med., Vol 150, No. 2, 08 1994, 555-557.
Effect of inhaled amiloride on water-induced bronchoconstriction in asthmatic children
H Mochizuki, T Shimizu, M Shigeta, K Tokuyama, A Morikawa and T Kuroume
Department of Pediatrics, Gunma University School of Medicine, Maebashi, Japan.
To determine whether the inhaled diuretic, amiloride, can modify
bronchoconstriction induced by ultrasonically nebulized distilled water
(UNDW) in asthmatic children, a double-blind, randomized, placebo-
controlled study was done. The UNDW inhalation challenge was performed in
12 asthmatic children (nine boys and three girls; mean age +/- SEM, 11.2
+/- 0.75 yr), who had at least a 20% fall in FEV1 after UNDW inhalation. On
separate days, these subjects underwent UNDW inhalation challenge after
inhalation of amiloride (0.3 mg/m2 body surface area) or placebo (0.9%
saline). Neither bronchodilation nor bronchoconstriction after amiloride
inhalation was observed. The mean value and SEM of the UNDW PD20 after
placebo inhalation was 4.55 +/- 0.80 ml. After inhalation of amiloride,
PD20 increased to 7.93 +/- 0.75 ml (p < 0.01). We concluded that inhaled
amiloride exerted a protective effect against UNDW-induced
bronchoconstriction in asthmatic children.
