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Am. J. Respir. Crit. Care Med., Vol 150, No. 1, 07 1994, 109-112.

Post-insult treatment with interleukin-1 receptor antagonist decreases oxidative lung injury in rats given intratracheal interleukin-1

JA Leff, ME Bodman, OJ Cho, S Rohrbach, OK Reiss, JL Vannice and JE Repine
Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver 80262.

Systemic administration of recombinant human interleukin-1 receptor antagonist (IL-1Ra) caused a rapid and sustained elevation of plasma IL- 1Ra levels and decreased the leak of intravascularly injected 125I- labeled albumin into lungs of rats given human recombinant interleukin- 1 intratracheally. IL-1Ra treatment decreased leak when given 0.5 h before, 1.25 h after, or 2.5 h after IL-1 administration. Similarly, IL- 1Ra treatment decreased lavage leukocytes and neutrophils when given 0.5 h before, 1.25 h after, or 2.5 h after IL-1 administration. Pretreatment with IL-1Ra also decreased lung myeloperoxidase activity and breath H2O2 concentration increases in rats given IL-1 intratracheally. Our results suggest that IL-1Ra treatment may decrease acute lung injury and neutrophil influx even when given after an IL-1 inciting insult.


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Copyright © 1994 American Thoracic Society