GR Bernard, A Artigas, KL Brigham, J Carlet, K Falke, L Hudson, M Lamy, JR Legall, A Morris and R Spragg
Vanderbilt University, Nashville, Tennessee.

The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and financial cost. The reported annual incidence in the United States is 150,000 cases, but this figure has been challenged, and it may be different in Europe. Part of the reason for these uncertainties are the heterogeneity of diseases underlying ARDS and the lack of uniform definitions for ARDS. Thus, those who wish to know the true incidence and outcome of this clinical syndrome are stymied. The American- European Consensus Committee on ARDS was formed to focus on these issues and on the pathophysiologic mechanisms of the process. It was felt that international coordination between North America and Europe in clinical studies of ARDS was becoming increasingly important in order to address the recent plethora of potential therapeutic agents for the prevention and treatment of ARDS.

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				A. B. Leibowitz and J. M. Oropello The Pulmonary Artery Catheter in Anesthesia Practice in 2007: An Historical Overview With Emphasis on the Past 6 Years Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2007; 11(3): 162 - 176. [Abstract] [PDF]

				M. Cepkova, V. Kapur, X. Ren, T. Quinn, H. Zhuo, E. Foster, K. D. Liu, and M. A. Matthay Pulmonary Dead Space Fraction and Pulmonary Artery Systolic Pressure as Early Predictors of Clinical Outcome in Acute Lung Injury Chest, September 1, 2007; 132(3): 836 - 842. [Abstract] [Full Text] [PDF]

				S. K Leaver and T. W Evans Acute respiratory distress syndrome BMJ, August 25, 2007; 335(7616): 389 - 394. [Full Text] [PDF]

				J. W. Lee, X. Fang, G. Dolganov, R. D. Fremont, J. A. Bastarache, L. B. Ware, and M. A. Matthay Acute Lung Injury Edema Fluid Decreases Net Fluid Transport across Human Alveolar Epithelial Type II Cells J. Biol. Chem., August 17, 2007; 282(33): 24109 - 24119. [Abstract] [Full Text] [PDF]

				S. Kleinman, O. Gajic, E. Nunes, and on behalf of the American Association of Blood Ban Promoting Recognition and Prevention of Transfusion-Related Acute Lung Injury Crit. Care Nurse, August 1, 2007; 27(4): 49 - 53. [Full Text] [PDF]

				T. W. Rice, A. P. Wheeler, G. R. Bernard, D. L. Hayden, D. A. Schoenfeld, L. B. Ware, and for the National Institutes of Health, National He Comparison of the SpO2/FIO2 Ratio and the PaO2/FIO2 Ratio in Patients With Acute Lung Injury or ARDS Chest, August 1, 2007; 132(2): 410 - 417. [Abstract] [Full Text] [PDF]

				R Zhai, M N Gong, W Zhou, T B Thompson, P Kraft, L Su, and D C Christiani Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS Thorax, August 1, 2007; 62(8): 718 - 722. [Abstract] [Full Text] [PDF]

				T. Itoh, H. Obata, S. Murakami, K. Hamada, K. Kangawa, H. Kimura, and N. Nagaya Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L446 - L452. [Abstract] [Full Text] [PDF]

				M. Wygrecka, R. E. Morty, P. Markart, S. M. Kanse, P. A. Andreasen, T. Wind, A. Guenther, and K. T. Preissner Plasminogen Activator Inhibitor-1 Is an Inhibitor of Factor VII-activating Protease in Patients with Acute Respiratory Distress Syndrome J. Biol. Chem., July 27, 2007; 282(30): 21671 - 21682. [Abstract] [Full Text] [PDF]

				J. G. Parambil, J. L. Myers, M.-C. Aubry, and J. H. Ryu Causes and Prognosis of Diffuse Alveolar Damage Diagnosed on Surgical Lung Biopsy Chest, July 1, 2007; 132(1): 50 - 57. [Abstract] [Full Text] [PDF]