GR Bernard, A Artigas, KL Brigham, J Carlet, K Falke, L Hudson, M Lamy, JR Legall, A Morris and R Spragg
Vanderbilt University, Nashville, Tennessee.

The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and financial cost. The reported annual incidence in the United States is 150,000 cases, but this figure has been challenged, and it may be different in Europe. Part of the reason for these uncertainties are the heterogeneity of diseases underlying ARDS and the lack of uniform definitions for ARDS. Thus, those who wish to know the true incidence and outcome of this clinical syndrome are stymied. The American- European Consensus Committee on ARDS was formed to focus on these issues and on the pathophysiologic mechanisms of the process. It was felt that international coordination between North America and Europe in clinical studies of ARDS was becoming increasingly important in order to address the recent plethora of potential therapeutic agents for the prevention and treatment of ARDS.

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				K. D. Liu and M. A. Matthay Advances in Critical Care for the Nephrologist: Acute Lung Injury/ARDS Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(2): 578 - 586. [Abstract] [Full Text] [PDF]

				A. L. Lagan, D. D. Melley, T. W. Evans, and G. J. Quinlan Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L161 - L174. [Abstract] [Full Text] [PDF]

				C. Quesnel, S. Marchand-Adam, A. Fabre, J. Marchal-Somme, I. Philip, S. Lasocki, V. Lecon, B. Crestani, and M. Dehoux Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L334 - L343. [Abstract] [Full Text] [PDF]

				H. R. Bream-Rouwenhorst, E. A. Beltz, M. B. Ross, and K. G. Moores Recent developments in the management of acute respiratory distress syndrome in adults Am. J. Health Syst. Pharm., January 1, 2008; 65(1): 29 - 36. [Abstract] [Full Text] [PDF]

				M. Iglesias, E. Martinez, J. R. Badia, and P. Macchiarini Extrapulmonary Ventilation for Unresponsive Severe Acute Respiratory Distress Syndrome After Pulmonary Resection Ann. Thorac. Surg., January 1, 2008; 85(1): 237 - 244. [Abstract] [Full Text] [PDF]

				L. Durairaj and G. A. Schmidt Fluid Therapy in Resuscitated Sepsis: Less Is More Chest, January 1, 2008; 133(1): 252 - 263. [Abstract] [Full Text] [PDF]

				K. M. Schuster, R. Alouidor, and E. S. Barquist Nonventilatory Interventions in the Acute Respiratory Distress Syndrome J Intensive Care Med, January 1, 2008; 23(1): 19 - 32. [Abstract] [PDF]

				U. Lucangelo, F. Bernabe, S. Vatua, G. Degrassi, A. Villagra, R. Fernandez, P. V. Romero, P. Saura, M. Borelli, and L. Blanch Prognostic Value of Different Dead Space Indices in Mechanically Ventilated Patients With Acute Lung Injury and ARDS Chest, January 1, 2008; 133(1): 62 - 71. [Abstract] [Full Text] [PDF]

				L. Gargani, F. Frassi, G. Soldati, P. Tesorio, M. Gheorghiade, and E. Picano Ultrasound lung comets for the differential diagnosis of acute cardiogenic dyspnoea: A comparison with natriuretic peptides Eur J Heart Fail, January 1, 2008; 10(1): 70 - 77. [Abstract] [Full Text] [PDF]

				R. A. Oeckler and R. D. Hubmayr Ventilator-associated lung injury: a search for better therapeutic targets Eur. Respir. J., December 1, 2007; 30(6): 1216 - 1226. [Abstract] [Full Text] [PDF]

				A. Borri, F. Leo, G. Veronesi, P. Solli, D. Galetta, R. Gasparri, F. Petrella, P. Scanagatta, D. Radice, and L. Spaggiari Extended pneumonectomy for non-small cell lung cancer: morbidity, mortality, and long-term results. J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1266 - 1272. [Abstract] [Full Text] [PDF]