Am. J. Respir. Crit. Care Med., Vol 149, No. 1, 01 1994, 239-241.
Successful treatment of invasive pulmonary aspergillosis in chronic granulomatous disease with orally administered itraconazole suspension
DA Spencer, P John, SR Ferryman, PH Weller and P Darbyshire
Birmingham Children's Hospital, United Kingdom.
A 3-yr-old boy with known chronic granulomatous disease presented with a
left-sided chest wall mass. Extensive intrathoracic and extrathoracic
aspergillosis was confirmed by CT scan-guided percutaneous biopsy.
Initially, he was treated intravenously with liposomal amphotericin and
subcutaneous gamma-interferon, but his clinical condition deteriorated over
7 wk of treatment. The amphotericin was therefore discontinued, and
itraconazole in an oral suspension was begun. There was progressive
clinical improvement after 3 months of this regime, and marked radiologic
clearing was apparent after 8 months of treatment. A multicenter trial of
this mode of therapy in patients with invasive aspergillosis is indicated.
