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Liquid Ventilation
During partial liquid ventilation in the setting of ventilator-induced lung injury in rats, Ricard and coworkers
studied the influence of varying the dose of perfluorocarbon from 0 to 20 ml per kg. A high dose of perfluorocarbon (20 ml per kg) aggravated the lung capillary leak induced by ventilation at a tidal volume of 33 ml per kg. The leak was decreased partially by PEEP of 5 cm H2O. A low dose of perfluorocarbon (10 ml per kg) decreased the amount of capillary leak induced by ventilation without perfluorocarbon or with a high dose of perfluorocarbon. PEEP had no effect on the capillary leak observed at the low dose of perfluorocarbon. The high dose of perfluorocarbon was accompanied by a 68% increase in functional residual capacity (FRC); this gas trapping was reduced by PEEP of 5 cm H2O. The authors conclude that the effect of perfluorocarbon on the vulnerability to ventilator-induced lung injury is complex: low doses of perfluorocarbon protect against lung capillary leak whereas high doses aggravate the leak (and the latter can be reduced by the addition of PEEP).
1 Citation displayed.
Dose–Response Effect of Perfluorocarbon Administration on Lung Microvascular Permeability in Rats
- Jean-Damien Ricard, Didier Dreyfuss, Jean-Pierre Laissy, and Georges Saumon
Am. J. Respir. Crit. Care Med. 168: 1378 -1382. First published online as doi:10.1164/rccm.200206-527OC
[Abstract]
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