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Inhaled Diuretics
To investigate the effect of inhaled furosemide on the sensation of dyspnea during exercise, Ong and coworkers performed a double-blind, randomized, crossover study in 19 patients with moderate to severe COPD. Inhalation of furosemide alleviated the sensation of dyspnea induced by constant-load exercise testing (mean dyspneic visual analogue scale score: 33.7 ± 25.2) as compared with placebo (visual analogue scale score: 42.4 ± 24; p = 0.014). Moreover, furosemide induced a small but significant improvement in mean FEV1 after exercise testing (FEV1 45.37 ± 16.66% predicted) as compared with placebo (FEV1 43.53 ± 14.53% predicted, p < 0.05). The authors concluded that the overall reduction in dyspneic sensation produced by furosemide during endurance testing might be caused, at least in part, by its bronchodilator effect, but also suggested that other mechanisms may be involved, such as effects on the airway epithelium, sensory nerve endings, or an inhibition of mediator release from inflammatory cells
1 Citation displayed.
Effects of Inhaled Furosemide on Exertional Dyspnea in Chronic Obstructive Pulmonary Disease
- Kian-Chung Ong, Ai-Ching Kor, Wai-Fung Chong, Arul Earnest, and Yee-Tang Wang
Am. J. Respir. Crit. Care Med. 169: 1028 -1033. First published online as doi:10.1164/rccm.200308-1171OC
[Abstract]
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