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Nasal Inflammation
Because individuals with asthma usually have inflammation in the nose, Pinto and colleagues hypothesized that treatment with an intranasal steroid would reduce nasal inflammation and further decrease nasal conditioning capacity. In a randomized, double-blind, placebo-controlled, two-way crossover study on 20 subjects with asthma, the authors compared the effect of treatment with intranasal budesonide for 2 weeks on nasal conditioning. Treatment with budesonide caused no significant effect on nasal conditioning as compared with placebo. In the subgroup of nonsmoking subjects, budesonide caused a significant reduction in nasal conditioning. The results suggest that nasal inflammation in nonsmoking individuals with asthma increases the conditioning capacity, and reducing it with an intranasal steroid worsens the ability of the nose to condition air. In addition, smoking causes an increase in nasal conditioning capacity by non–steroid-dependent factors.
1 Citation displayed.
Treatment of Nasal Inflammation Decreases the Ability of Subjects with Asthma to Condition Inspired Air
- Jayant M. Pinto, Paraya Assanasen, Fuad M. Baroody, Edward Naureckas, Julian Solway, and Robert M. Naclerio
Am. J. Respir. Crit. Care Med. 170: 863 -869. First published online as doi:10.1164/rccm.200309-1271OC
[Abstract]
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