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Cough
Airway inflammation has been previously demonstrated in patients with chronic cough; it has been suggested that the mechanism underlying chronic cough may be through the release of tussive mediators that activate afferent sensory nerve endings. Birring and coworkers measured concentrations of both proinflammatory and tussive mediators (histamine, cysteinyl leukotrienes, prostaglandin D2 and E2, and IL-8) in the supernatant from induced sputum in 20 patients with cough-variant asthma or eosinophilic bronchitis, 20 patients with nonasthmatic cough, 22 patients with idiopathic chronic cough, and 18 control subjects. Sputum histamine concentrations were higher in patients with idiopathic cough (8.0 ng/ml) and cough-variant asthma/eosinophilic bronchitis (10.2 ng/ml) than in normal subjects (2.6 ng/ml, p < 0.01). All categories of chronic cough had significant elevations of prostaglandin D2 and E2 in sputum. These data indicate that the inflammatory and tussive mediators are released in patients with chronic cough and also that similarities in the mechanism of chronic cough might occur in a diverse range of conditions.
1 Citation displayed.
Induced Sputum Inflammatory Mediator Concentrations in Chronic Cough
- Surinder S. Birring, Debbie Parker, Christopher E. Brightling, Peter Bradding, Andrew J. Wardlaw, and Ian D. Pavord
Am. J. Respir. Crit. Care Med. 169: 15 -19. First published online as doi:10.1164/rccm.200308-1092OC
[Abstract]
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