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Pathophysiologic and Radiologic Studies
Parr and colleagues detailed the differences over time on CT scans in a cohort of patients deficient in  1-antitrypsin. The authors astutely recognized that, in a group of individuals with a disease that should be getting progressively worse over time, the CT scans were showing improvement. When the studies over time were corrected with the use of an anatomic phantom, which benchmarked bone, water, and air, the expected progression of emphysema, with the accompanying decrease in lung density became apparent. Although this study has direct applicability to follow-up of patients with emphysema, it is likely that long-term CT follow-up of many lung diseases would benefit by benchmarking the CTs to a known correction factor.
In a summary report from a National Heart, Blood, and Lung Institute Workshop, Croxton and colleagues
discuss needs for opportunities for research on COPD.
Citations 1-2 of 2 total displayed.
Influence of Calibration on Densitometric Studies of Emphysema Progression Using Computed Tomography
- David G. Parr, Berend C. Stoel, Jan Stolk, Peter G. Nightingale, and Robert A. Stockley
Am. J. Respir. Crit. Care Med. 170: 883 -890. First published online as doi:10.1164/rccm.200403-326OC
[Abstract]
[Full text]
Clinical Research in Chronic Obstructive Pulmonary Disease: Needs and Opportunities
- Thomas L. Croxton, Gail G. Weinmann, Robert M. Senior, Robert A. Wise, James D. Crapo, and A. Sonia Buist
Am. J. Respir. Crit. Care Med. 167: 1142-1149.
[Abstract]
[Full text]
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